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Division of Chemical Toxicology

The mission of the Division is to improve human health and public welfare by promoting the understanding of chemical mechanisms that govern disease processes and the toxicity of drugs, environmental agents, and endogenous chemicals. This will be accomplished by (1) providing a forum for communicating research in the field of chemical toxicology; (2) encouraging further research into chemical mechanisms of toxicity; (3) providing a rigorous scientific basis for risk assessment; (4) providing continuing education, leadership training, and career development opportunities for our fellow chemists; and (5) sponsoring with other societies and divisions, symposia and other programs of mutual interest.

Division of Chemical Toxicology News

DIVISION OF CHEMICAL TOXICOLOGY

Thomas Spratt, Program Chair

SUNDAY MORNING

Translesion DNA Polymerases

Z. Suo, Organizer, Presiding

8:30 Introductory Remarks.

8:35 . Mechanisms to Coordinate Multiple DNA Polymerases for TLS. M.A. Trakselis

9:15 . Explosive mutation accumulation triggered by heterozygous human Pol å proofreading- deficiency is driven by suppression of mismatch repair. Z.F. Purcell

9:55 Intermission.

10:10 . Finding their way: How error-prone polymerases gain access to the bacterial replisome. J.J. Loparo

10:50 . Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA Polymerase. R. Vayas, G. Efthimiopoulos, J. Tokarsky, C. Malik, A.K. Basu, Z. Suo

SUNDAY AFTERNOON

Founders’ Award

Cosponsored by PROF
J. L. Bolton, Organizer, Presiding

1:00 Introductory Remarks.

1:10 . Biological targets of electrophilic furan metabolites. L.A. Peterson

1:50 . Mass spectrometry studies of DNA and protein adducts of reactive electrophiles. N.Y. Tretyakova

2:30 . Electrophilic targeting of Keap1/Nrf2 signalling for disease prevention and treatment. A. Dinkova-Kostova, T. Honda, A.Y. Abramov

3:10 Intermission.

3:25. Chasing Rainbows? Targeted covalent ligand design guided by precision electrophile signaling technologies. Y. Aye

4:05 . Botanicals electrophiles modify multiple targets. J.L. Bolton

Innovations in Chemistry Supporting Strategic Human Health Risk Assessments

Sponsored by AGRO, Cosponsored by CHAS and TOXI

MONDAY MORNING

Student/Post-Doc

E. G. Prestwich, U. Sarkar, Organizers, Presiding

8:00 . Repair and processing of DNA lesions induced by a dynamic electrophile. S. Byrne, K. Yang, S. Rokita

8:20 . Mechanisms of bioactivation of the tobacco carcinogens and 2-amino-9H-pyrido[2,3- b]indole (AáC) and 4-aminobiphenyl (4-ABP) in human bladder.. M. Bellamri, L. Yao, R. Turesky

8:40 . Development of a novel approach for measuring N’-nitrosnornicotine bioactivation in humans by using deuterium-labeled analogs. E. Carlson, A. Goode, V. Gurvich, I. Stepanov, V. Jain, P. Upadhyaya, S.S. Hecht

9:00 . A scheduled LC-SRM method for targeted DNA adductome analysis. Y. Cui, P. Wang, Y. Wang

9:20 Intermission.

9:30 . Significant impact of divalent metal ions on the fidelity, sugar selectivity, and drug incorporation efficiency of human PrimPol. J. Tokarsky, P. Wallenmeyer, K. Phi, Z. Suo

9:50 . Incorporating histone H2A variants facilitates global excision of uracil residues in nucleosomes. C. Li, S. Delaney

10:10. Integrating multi-“omics”- mass spectrometry-based methods to characterize electronic cigarette exposure in humans. R.P. Dator, P.W. Villalta, C.J. Hooyman, L.A. Maertens, S. Balbo

10:30 . The C’5-pseudouridinyl radical. I. Sappy

10:50 Intermission.

11:00 . Transcriptional inhibition and repair mechanism of alkyl phosphotriester DNA adducts in mammalian cells. Y. Tan, J. Wu, Y. Wang

11:20 . Mass spectroscopy-based metabolomics reveals new insights on the biological effects of copper oxide nanoparticles in a human colon carcinoma cell line. N.G. Chavez Soria, D.S. Aga, G. Atilla-Gokcumen

11:40 . A Sensitive Method for Quantitation of Abasic Sites in Isolated and Cellular DNA byElectrospray Ionization Tandem Mass Spectrometry. H. Chen, C.J. Rizzo, R.J. Turesky

MONDAY AFTERNOON

Chemical Toxicology of Nanomaterials

S. Balbo, Organizer, Presiding

1:00 Introductory Remarks.

1:05 . Investigation of toxicity mechanism of nano-scale lithium battery material NMC to bacterial models. V. Feng

1:45 . The size, surface chemistry and reactivity – all matter as toxicity determinants of fibrous nanomaterials. A.A. Shvedova

2:25 . DNA methylation alterations by nanoparticles. L. Godderis

3:05 Intermission.

3:20 . The Future of Nanotoxicology Research: Filling Knowledge Gaps to Safeguard Health. A. Elder

4:00 . Nanomaterial Induced Mechanisms: Focus on Nano Cell Interactions. A. Kraegeloh

MONDAY EVENING

Sci-Mix

T. Spratt, Organizer

8:00 – 10:00

Modified 3-deaza-3-alkyl-adenosines as minor groove alkylation mimics in translesion DNA synthesis. L.J. Weselinski, V. Begoyan, G. Kenyon, M. Tanasova

Ultrasensitive high-resolution mass spectrometric analysis of methyl DNA phosphate adducts in human lung. B. Ma, P.W. Villalta, J.B. Hochalter, I. Stepanov, S.S. Hecht

Application of an in silico tool for the risk assessment of an industrial process compliant to ICH M7 guidelines. M. Burns, M. Ott, S.J. Webb

Structural and dynamic impact of single ribonucleotide incorporation on nucleosome structure.I. Fu, D. Smith, S. Broyde

Identification of photo-degradation products of nitroguanidine and toxicological implications. L. Moores, A. Kennedy, K.A. Gust, M.K. Shukla, L.K. Rabalais, D.L. Henderson, S.J. Jones

Efficiency of Initiating Base Excision Repair on Nucleosome Substrates. A. Garlow, S. Delaney

Nanomaterials in marine environment: toxicity to Artemia salina with and without the presence of Phe and Cd2+. J. Lu, X. Lv, Z. Chen, X. Zhu

Initiation of repair of DNA nucleobase lesions in the nucleosome core particle. M.E. Tarantino, S. Delaney

High-resolution/accurate mass DNA adductomics to screen for doxorubicin-induced adducts as biomarkers of therapeutic efficacy. A. Stornetta, K. Walters, R.P. Dator, V. Guidolin, P.W. Villalta, S. Balbo

Molecular level studies of the impact of poly (oxonorbornenes) and their gold nanoparticles conjugates on D. rerio. embryos. J.N. Klutts, A. Laranang, Z. Zheng, J. Saar, K. Lienkamp, R. Brewster, Z. Rosenzweig

Determining the basis of E. coli DinB and human pol kappa DNA damage specificity. H. Stern, T.A. Coulther, J. Winters, C.L. Mills, M.J. Ondrechen, P. Beuning

DNA damage induced by oxidative stress and lipid peroxidation in leukocyte DNA from African-American and Caucasian smokers. C. Ruszczak, B. Ma, J. Jensen, D. Hatsukami, I. Stepanov

Potential DNA oxidation adducts for disease biomarkers. N.C. Wamer, E.A. Carlson, T.A. Dodson, E.G. Prestwich

Investigation of the effect of 2-phenethyl isothiocyanate (PEITC) on the levels of 4-hydroxy-1- (3-pyridyl)-1-butanone-releasing DNA adducts in oral cells of smokers. A. Jain, G. Yakovlev, B. Ma, I. Stepanov

Petrogenic and pyrogenic polycyclic aromatic hydrocarbons in human urine: comparison of their levels between two geographic regions. C. Mesaros, M. Huang, L.C. Hackfeld, R.P. Hodge, I.A. Blair, T.M. Penning

Surface-modified gold nanoparticles and their long-term impact on cellular pathways. P. Falagan Lotsch, E. Grzincic, C.J. Murphy

Independent Synthesis and Fate of DNA Lesions Generated from Oxidative Damage at the C-3 and C-5 Position of Deoxyribonucleotides. M. Bedi, A.C. Bryant-Friedrich

EB-Fapy-dG adducts of 1,3-butadiene: synthesis, structural identification, and detection in human cells. S.S. Pujari, A. Groehler, D. Najjar, N.Y. Tretyakova

Smoking and inflammation mediated epigenetic changes in a mouse model of lung cancer. J. Fernandez, C. Seiler, Q. Han, N.Y. Tretyakova

Inter-individual differences in metabolism of 1,3-butadiene. A. Degner, G. Madugundu, R. Arora, L.A. Peterson, N.Y. Tretyakova

TUESDAY MORNING

Mechanisms of Binding, Transport & Biotransformation of Toxic Metals

Cosponsored by INOR
B. P. Rosen, Organizer, Presiding

8:30 . Mechanisms of Binding, Transport & Biotransformation of Toxic Metals. T. Pinter, L. Ruckthong, C. Ervin, V.L. Pecoraro

9:15 . ArsI, a C-As lyase for degradation of environmental organoarsenicals. V.S. Nadar, M. Yoshinaga, B.P. Rosen

10:00 . Understanding the Mechanism of Carbon-Metal Bond Cleavage by the Organomercurial Lyase MerB.. H. Wahba, M. Stevenson, D. Wilcox, J.G. Omichinski

10:45 . Interplay of copper transport proteins in the processing of platinum anticancer drugs in the cell. N. Dolgova, C. Yu, O. Dmitriev

TUESDAY AFTERNOON

Chemical Research in Toxicology Young Investigator Award

W. Chan, Organizer, Presiding

1:00 Introductory Remarks.

1:10 . Oxidized polyunsaturated fatty acids: Are they toxic or bioactive?. J. Lee

1:50 . Antibiotics induce nitrosative stress in microorganisms. C.T. Chan

2:30 Intermission.

2:45. Advances in Human Biomonitoring of Carcinogens by Ion Trap and High Resolution Accurate Mass Spectrometry. R. Turesky

3:25. Chemical approaches to investigate the toxicity of aristolochic acids. W. Chan

Keynote Lectures

T. Spratt, Organizer
N. E. Geacintov, Presiding

4:30 Introductory Remarks.

4:40. Linking mutational spectra of chemical carcinogens to the mutational patterns seen in human tumors. J. Essigmann, B.I. Fedeles

TUESDAY EVENING

Posters

T. Spratt, Organizer

7:00 – 9:00

Prediction of carcinogenic behavior of hexacyclic polycyclic aromatic hydrocarbons using aromatic sextet theory and ionization potentials. J.O. Ona Ruales

Toxic Effects and Molecular Mechanism of Silver Nanoparticles to Daphnia magna. J. Hou

Modified 3-deaza-3-alkyl-adenosines as minor groove alkylation mimics in translesion DNA synthesis. L.J. Weselinski, V. Begoyan, G. Kenyon, M. Tanasova

Ultrasensitive high-resolution mass spectrometric analysis of methyl DNA phosphate adducts in human lung. B. Ma, P.W. Villalta, J.B. Hochalter, I. Stepanov, S.S. Hecht

Screening for DNA Adducts in Human Colon by High-Resolution Nano-ESI UHPLC/MSn. D. Konorev, R. Turesky

Application of an in silico tool for the risk assessment of an industrial process compliant to ICH M7 guidelines. M. Burns, M. Ott, S.J. Webb

Methylation in human hemoglobin is associated with age as analyzed by liquid chromatography tandem mass spectrometry. H.C. Chen, S. Ip

Characterizing Uracil DNA Glycosylase Processivity in Nucleosome Core Particles. E. Kennedy, S. Delaney

Structural and dynamic impact of single ribonucleotide incorporation on nucleosome structure. I. Fu, D. Smith, S. Broyde

Identification of photo-degradation products of nitroguanidine and toxicological implications. L. Moores, A. Kennedy, K.A. Gust, M.K. Shukla, L.K. Rabalais, D.L. Henderson, S.J. Jones

Gallic acid derivatives inhibit DNA repair enzyme ALKBH2. Q. Tang, F. Chen, H. Ma, K. Bian, D. Li

Conformation-specific replication block from bulky 4-aminobiphenyl-modified DNA lesions. A. Cai, K. Bian, F. Chen, D. Li, B. Cho

Mutagenicity of DNA-Peptide Crosslink in Human cells. S. Naldiga, S. Ji, G. Moldovan, N.Y. Tretyakova, A.K. Basu

Efficiency of Initiating Base Excision Repair on Nucleosome Substrates. A. Garlow, S. Delaney

Replication studies of N3-methyladenine in Escherichia coli cells. J. Yuan, Y. Wang

Unmasking the role of protein modification in the observed toxicity of aristolochic acid. C. Chan, W. Chan

Adverse reactions induced by the antiepileptic drug oxcarbazepine may stem from its metabolic biotransformation to carbamazepine. I. Martins, C. Charneira, M. Marques, A. Antunes

Identification of 4-(methylnitroamino)-1-(3-pyridyl-1-oxide)-1-butanone, a novel metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rat urine. L. von Weymarn, R. Dator, S. Balbo, S.E. Murphy

Initiation of repair of DNA nucleobase lesions in the nucleosome core particle. M.E. Tarantino, S. Delaney

Dual cell system for in vitro studies of toxic blood gases. W.G. Senanayake, I. Petrikovics, D.E. Thompson

Analysis of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human lung DNA from smokers and nonsmokers. J. Yang, S. Balbo, P.W. Villalta, S.S. Hecht

High-resolution/accurate mass DNA adductomics to screen for doxorubicin-induced adducts as biomarkers of therapeutic efficacy. A. Stornetta, K. Walters, R.P. Dator, V. Guidolin, P.W. Villalta, S. Balbo

Molecular level studies of the impact of poly (oxonorbornenes) and their gold nanoparticles conjugates on D. rerio. embryos. J.N. Klutts, A. Laranang, Z. Zheng, J. Saar, K. Lienkamp, R. Brewster, Z. Rosenzweig

Oxidation and Removal of Cytosine Derivatives in the Nucleosome. P. Caffrey, S. Delaney

Determining the basis of E. coli DinB and human pol kappa DNA damage specificity. H. Stern, T.A. Coulther, J. Winters, C.L. Mills, M.J. Ondrechen, P. Beuning

Prediction of the interaction region between the Y-family polymerase DinB and the transcription-repair coupling factor Mfd in E. coli. S.K. Fields, P. Beuning

Machine learning models for predicting hepatic steatosis based on in vivo data. B. Zdrazil, S. Jain, S. Klinting, S. Escher, G.F. Ecker, U. Norinder

Predicting drug metabolites using bacterial-based models. P.C. Rosado, J.P. Cruz, M.C. Justino, M. Marques, G.C. Justino

pCharacterization of LexA-regulated protein YbfE in E. coli. A. Hotchkiss, C. Kramer, P. Beuning

DNA damage induced by oxidative stress and lipid peroxidation in leukocyte DNA from African-American and Caucasian smokers. C. Ruszczak, B. Ma, J. Jensen, D. Hatsukami, I. Stepanov

p Analysis of the spectrum of DNA modifications in Pseudomonas aeruginosa. E.A. Carlson, N.C. Wamer, T.A. Dodson, E.G. Prestwich

Probing the conformational dynamics of the Beta sliding clamp in Escherichia coli. M.L. Liriano, B. Koleva, P. Beuning

Potential DNA oxidation adducts for disease biomarkers. N.C. Wamer, E.A. Carlson, T.A. Dodson, E.G. Prestwich

Rapid microplate assay for acellular reactive oxygen species generation induced by engineered nanomaterials in real-time. R. Coreas, W. Zhong

Identifying toxicology concepts in the replacement of mercury catalysts during the acetylene hydrochlorination of vinyl chloride monomers. L. Green, J. Marshall, A.S. Cannon

Petrogenic and pyrogenic polycyclic aromatic hydrocarbons in human urine: comparison of their levels between two geographic regions. C. Mesaros, M. Huang, L.C. Hackfeld, R.P. Hodge, I.A. Blair, T.M. Penning

Dissecting interactions between E. coli DNA polymerase III and single-stranded DNA binding protein to gain insights into polymerase management. J. McIsaac, m. ondrechen, P.J. Beuning

Release of lead (Pb) and formation of disinfection byproducts during drinking water disinfection in the water distribution system. J. Liu, V.K. Sharma, C.M. Sayes

Mineralogy dependent dissolution of inhaled uranium in simulated lung fluids in uranium mine lands, New Mexico. E. Hettiarachchi, S. Paul, D. Cadol, B. Frey, G. Rubasinghege

Reactive oxygen species (ROS)-dependent release of an inhibitor from an aptamer. G. Premnauth, E.J. Merino

Effect of surface charge on toxicity of AuNPs; Are cationic AuNPs toxic?. E. Lee, Y. Kwon

Nanomaterials in marine environment: toxicity to Artemia salina with and without the presence of Phe and Cd2+. J. Lu, X. Lv, Z. Chen, X. Zhu

Molecular characterization of alcohol-induced DNA damage for cancer prevention. V. Guidolin, A. Carra’, P.W. Villalta, E. Carlson, S. Balbo

EB-Fapy-dG adducts of 1,3-butadiene: synthesis, structural identification, and detection in human cells. S.S. Pujari, A. Groehler, D. Najjar, N.Y. Tretyakova

Inter-individual differences in metabolism of 1,3-butadiene. A. Degner, G. Madugundu, R. Arora, L.A. Peterson, N.Y. Tretyakova

2, 2’, 3, 5’, 6 polychlorinated biphenyls (PCB-95) induce behavioral and GABAgenic neurotransmitter changes in zebrafish at early developmental exposure. P. Ranasinghe, C.M. Lee

Investigation of the effect of 2-phenethyl isothiocyanate (PEITC) on the levels of 4-hydroxy-1- (3-pyridyl)-1-butanone-releasing DNA adducts in oral cells of smokers. A. Jain, G. Yakovlev, B. Ma, I. Stepanov

Smoking and inflammation mediated epigenetic changes in a mouse model of lung cancer. J. Fernandez, C. Seiler, Q. Han, N.Y. Tretyakova

Independent Synthesis and Fate of DNA Lesions Generated from Oxidative Damage at the C-3’and C-5′ Position of Deoxyribonucleotides. M. Bedi, A.C. Bryant-Friedrich

Ecotoxicology of nano-perovskites in aquatic environment. T. Zhou, W. Fan

Thermodynamic exposure reduction by amendment techniques to limit bioaccumulation during ongoing depositional input – a sediment mesocosm study with three organisms. A.P. Wang

MegaTox for Predicting Compound Liabilities. K.M. Zorn, T. Lane, D.P. Russo, A. Clark, S. Ekins

Information-Derived Adverse Outcome Pathways with a Case Study on Structural Cardiotoxicity. A. Bender

Morphology-dependent cytotoxicity of SiC nanomaterials to human mesenchymal stem cells. F. Chen, G. Li, E. Zhao, J.V. Jokerst

Nanotoxicity predictive modeling: A case study on metal oxides nanoparticles. B. Rasulev

Surface-modified gold nanoparticles and their long-term impact on cellular pathways. P. Falagan Lotsch, E. Grzincic, C.J. Murphy

WEDNESDAY MORNING

Nanomaterials in Drug Delivery: Efficacy & Toxicity Considerations

Cosponsored by MEDI
P. F. Guengerich, W. G. Humphreys, N. A. Meanwell, Organizers, Presiding

8:00Introductory Remarks.

8:05. What exactly is toxic about colloidal nanoparticle formulations? Results from the molecular level and the cellular level. C.J. Murphy

8:45. Targeting or Enhanced Selectivity: Toxicological considerations of nanoparticle therapeutics. R. Darvari

9:25. Expansile nanoparticles for the treatment of intraperitoneal mesothelioma. M.W. Grinstaff

10:05 Intermission.

10:20. Debugging nano–bio interfaces. M. Mahmoudi

11:00. Understanding mast cell activation in the safe development of nanotechnologies. J. Brown

WEDNESDAY AFTERNOON

Topics in Chemical Toxicology

P. Beuning, Organizer
T. Spratt, Organizer, Presiding

1:00. Base and nucleotide excision repair of site-specific oxidatively generated guanine lesions in DNA substrates transfected into human cells. V. Shafirovich, K. Kropachev, M. Kolbanovskiy, N.E. Geacintov

1:20. Reduction pathway-dependent cytotoxicity of reduced graphene oxide. C. Zhang, Q. Zhang

1:40 . Site-Specific Production of Hydroxyl Radicals and Synergistic DNA Damage Induced by the Non-Enzymatic Activation of the Anti-Tuberculosis Drug Isoniazid by Cu(II). B. Zhu

2:00. Insights into the molecular mechanism of alkylation- and platination-induced mutagenesis. S. Lee, Y. Kou

2:20. Kinetic Basis of DNA Synthesis by Human DNA Polymerase/Primase PrimPol. L. Zhao

2:40 Intermission.

3:00. Levels of glyoxal-induced hemoglobin modifications correlate with DNA cross-links in human blood as determined by mass spectrometry. H.C. Chen, C. Liu

3:20. High mobility group box 1: a re-evaluation of its role in cancer. I.A. Blair, L. Weng, L. Guo, A. Vachani, C. Mesaros

3:40. Determining Associations between Transcriptomics and Toxicity using Co-Expression Network Methods. B. Alexander-Dann, T. James, A. Bender

4:00. Inhibitors of the mitochondrial respiratory complex – Structure-based prediction of toxicity. G.F. Ecker, F. Troger, S. Jain, B. Zdrazil

4:20. Configurational and Conformational Equilibria of the N6-(2-Deoxy-D-erythro- pentofuranoysl-)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine (MeFapy- dG) Lesion in DNA. M.P. Stone, S.N. Bamberger, C.K. Malik, T.L. Johnson-Salyard, S.K. Brown, H. Pan, C.J. Rizzo, M.W. Voehler

4:40 . Using open bioactivity data for developing machine-learning prediction models for chemical modulators of the retinoid X receptor (RXR) signaling pathway. S. Kim

Travel Awards to the 256th ACS Meeting in Boston.

Travel awards for students and post-docs will be available for the TOXI Program at the ACS Meeting  in Boston.  The students and post-docs will receive up to $750 to help pay for their travel expenses to the ACS Meeting.

The application should consist of a single pdf file containing:

1.       A nomination letter from the faculty advisor or laboratory director. The letter should explain why Travel Assistance Award funds are needed.

2.       A curriculum vitae for the applicant.

3.       The abstract for the work to be presented by the nominee at the meeting.

Applications can be submitted to Dr. Thomas Spratt at tes13@psu.edu  by July 1.

Hello Members

As some of you may know, for the past months we have been working with the team at ACS to develop a video, which would work to introduce the Division of Chemical Toxicology (TOXI) to the next generation of chemists and help to increase membership in the division.

The video is now completed and posted in two locations within American Chemical Society (ACS). It is accessible from the ACS website, www.acs.org, Technical Division page and on YouTube. From YouTube you can easily access it by typing your division acronym in the search bar on YouTube.

In this video, you will learn:

  • Importance of TOXI
  • Benefits of membership
  • A shared story from a member and how the division has personally enhanced their career

To increase exposure and awareness, we will also be featuring the video for one week throughout the various ACS media sources. We have created a schedule for when the video will be featured and this has been communicated to your division contact.

We want to remember that when we send, we are not just sending to our audience, we are sending to an audience within an audience. We encourage you to share the video within your network with the goal they will share it with their audience.

Thank You

Judy Bolton has been named the recipient of the 2018 Founders’ Award.  Judy Bolton is  currently Distinguished Professor and Head, Medicinal Chemistry and Pharmacognosy  at the University of Illinois at Chicago.  Dr Bolton’s research in chemical toxicology is primarily focused on post-menopausal women’s health. She studies the carcinogenic effects of estrogens and antiestrogens and investigates natural alternatives to hormone replacement therapy. She is interested in determining why women who are taking hormone replacement therapy or selective estrogen receptor modulators (SERMs) are at increased risk for developing hormone dependent cancers such as breast or endometrial cancers. By developing a good understanding of the mechanism of how these widely prescribe drugs lead to increased cancer risk, we will be able to design alternatives that maintain the beneficial properties of estrogens/SERMs without generating genotoxic side effects.  Dr Bolton has been active in  educating the next generation of breast cancer researchers and chemical biologists as she has  mentored over 20 Ph.D. and 25 postdoctoral fellows.  Dr Bolton will organize a symposium at the TOXI Division’s program this summer in Boston.

Division of Chemical Toxicology Election Results

Secretary

Hauh-Jyun Candy Chen, Ph.D., National Chung Cheng University

Candy Chen is a Professor in the Department of Chemistry and Biochemistry at National Chung Cheng University (NCCU) in Taiwan. She received her B.S. degree in Chemistry from National Cheng Kung University (NCKU) in Taiwan (1983) and Ph.D. degree in Organic Chemistry from State University of New York at Stony Brook (1988) under the supervision of Prof. Iwao Ojima. After postdoctoral work at the National Institutes of Health and the Rockefeller University, she joined American Health Foundation where she was later promoted to Associate Research Scientist, a tenure-track position. From 1997-2004, she held the positions of Assistant through Full Professor at NCCU. Her research interests started from medicinal chemistry to toxicological chemistry, and shifted to bioanalytical chemistry. She has developed several mass spectrometry­-based analytical methods for DNA and protein adducts in humans, aiming to find valid disease biomarkers.

She has published more than 50 scientific papers in leading journals with 4 patents granted. She received the Outstanding Research Award from NCCU in 2005 and was elected as the Extinguished Alumni from the Chemistry Department of NCKU in 2014. She served as the Executive Officer of the Taiwan Society for Mass Spectrometry (2007-2009 and 2012-2018) and Chair of the Female Chemist Organization (2014). She has been a member of the Editorial Advisory Board of Chemical Research in Toxicology since 2016.

Treasurer-elect

Zucai Suo, Ph.D., The Ohio State University

Zucai Suo received a B.S. (Chemistry) in 1986 and an M.S. (Physical Chemistry) in 1989 from Fudan University in Shanghai, China, and a Ph.D. (Biological Chemistry) in 1997 from Pennsylvania State University at University Park, PA, under the direction of K. A. Johnson. He was Jane Coffin Childs Memorial Fund Postdoctoral Fellow under the guidance of Christopher T. Walsh at Harvard Medical School, Boston, MA. He then spent 16 months as a senior biochemist at Eli Lilly & Company at Indianapolis, IN, and was in a team which successfully developed an anti-hepatitis C protease drug Telaprevir. After the short stay in industry, he moved to The Ohio State University at Columbus, OH, where he is currently a Professor of Chemistry and Biochemistry. He has served as a regular and ad hoc member of both NIH study panels and NSF review panels. In addition, he has been on the Editorial Advisory Boards of three research journals including Chemical Research in Toxicology and has served as a guest editor for PNAS. His research interests are in both antiviral and anti-cancer drug discovery, and the enzymology of DNA replication, DNA lesion bypass, DNA damage repair, and gene editing. He has published over 100 research papers and won several research awards including an NSF Career Award in 2005 and an OKeanos-CAPA Senior Investigator Award in 2017. In 2013, he was elected to be a fellow of American Association for the Advancement of Science. For the TOXI Division, he has served as Secretary since Jan. 1, 2016 and is or was a member of the Program Committee, Communications Committee, and Professional Development Committee.

Executive Committee, Member-at-Large

Kaushik Mitra, Ph.D., Merck

Kaushik Mitra is the Director of the Investigative and Molecular Toxicology group within the Department of Safety Assessment at Merck. In this capacity, he leads efforts to provide mechanistic understanding of toxicity of drug molecules, integrating such toxicology-related findings with medicinal chemistry and biotransformation sciences to help design potentially safe drug candidates. As part of the departmental leadership team, he is involved in establishing scientific and business strategies of the department, managing employee careers and evaluating the external landscape for appropriate opportunities. In his previous role as Director of Preclinical ADME in the Department of Pharmacodynamics, Pharmacokinetics and Drug Metabolism, Kaushik was responsible for preclinical PK/PD and biotransformation support to drug discovery and development portfolios. Kaushik received his Ph.D. degree in organic chemistry from the University of Missouri, Columbia and conducted post-doctoral research in the Department of Bioengineering at the Massachusetts Institute of Technology. Research during Kaushik’s academic career was focused on understanding covalent and non-covalent interactions of therapeutically relevant small molecules with proteins and DNA. Kaushik was the recipient of the Susan G. Komen Breast Cancer Foundation Post-doctoral Fellowship Award and a Young Investigator Award from the Division of Chemical Toxicology of The American Chemical Society for his research at MIT. He has published his research work in several international journals, has conducted short courses on topics of safety and drug metabolism, and has served as an invited speaker in several national and international conferences.

Councilor

Penny Buening, Ph.D., Northeastern University

Penny Buening received a B.A. in Chemistry from Macalester College in St. Paul, MN, and a Ph.D. from the University of Minnesota in the field of RNA-protein interactions and RNA biochemistry. She completed postdoctoral research focused on protein-protein interactions that regulate cellular responses to DNA damage at the Massachusetts Institute of Technology in the laboratory of Graham C. Walker. She is currently an Associate Professor of Chemistry and Chemical Biology at Northeastern University in Boston. Her research on DNA damage tolerance and protein engineering has been recognized with the 2015 Chemical Research in Toxicology Young Investigator Award, a Cottrell Scholar Award, an NSF CAREER Award, and an American Cancer Society Research Scholar Grant. A major research focus is on the specificity and regulation of Y family DNA polymerases. Prof. Beuning has been active in efforts to enhance the recruitment and retention of groups traditionally underrepresented in the sciences. She has served ACS as a facilitator for the Postdoc-to-Faculty workshops and New Faculty Workshops. She has served the TOXI Division by chairing the oral session of the Young Investigator Symposium in 2012, serving as a judge for the Young Investigator poster session, as a member of the Professional Development Committee, as Councilor from 2015-2017, and serving as a guest editor for Chemical Research in Toxicology.

Councilor/Alternate Councilor

Irina Stepanov, Ph.D., University of Minnesota

Irina Stepanov, received as BS (1997) and PhD (2002) in Chemistry from Moldova State University in Chisinau, Moldova. She joined the laboratory of Stephen Hecht at the University of Minnesota in 2003, first as a Postdoctoral Associate and later as a Research Associate. Dr. Stepanov’s research is aimed at understanding the toxic, carcinogenic, and addictive potential of tobacco product use, with the specific focus on quantitative and mechanistic links between tobacco product chemical composition and subsequent exposures and disease risk in tobacco users. Her research methodologies span from chemical characterization of tobacco and cigarette smoke to the development and application of biological markers for tobacco constituent exposure, metabolism, and effect in humans. Her laboratory has developed novel unique highly sensitive approaches to the measurement of blood and oral cell DNA adducts formed as the result of exposure to tobacco constituents, oxidative stress, and inflammation. Currently, she is the principal investigator on two R01 and one U01 grants in the field of tobacco regulatory science. She is also actively involved in the global research capacity building and is a co-PI on a recently awarded grant from the Fogarty Center to develop laboratory capacity for tobacco product and biomarker analyses in India. Dr. Stepanov served on numerous NIH review panels, is on the editorial board for the journal Scientific Reports, an Associate Editor for Tobacco Regulatory Science, and with the Society for Research on Nicotine and Tobacco she is co-Chair of the Education Subcommittee and the Advisory Board member for the Global health Network. For the TOXI Division, she served as a member of Professional Development Committee, Communications Committee, and is an Executive Committee Member-at-Large.

Nominations Committee Member

Yinsheng Wang, Ph.D., University of California at Riverside

Yinsheng Wang received his Ph. D. degree from Washington University in St. Louis after obtaining his BS and MS degrees from Shandong University and Dalian Institute of Chemical Physics, Chinese Academy of Sciences, respectively. He joined the faculty of the University of California Riverside in 2001, where he is now a Professor and Donald T. Sawyer Endowed Founder’s Chair in Chemistry. Yinsheng also serves as the Director for the Environmental Toxicology graduate program, and directs the NIEHS-funded T32 training program in Environmental Toxicology at UC Riverside. His current research involves the use of mass spectrometry, along with synthetic organic chemistry and molecular biology, for examining the occurrence and biological consequences of DNA damage and for assessing the biological functions of post-translational modifications of proteins. Yinsheng has trained or in the process of training of over 70 Ph. D. students and post-doctoral fellows, and he has co-authored more than 220 research articles. Yinsheng was named as a fellow for the American Association for the Advancement of Sciences in 2012, and he was the recipient for the inaugural Chemical Research in Toxicology Young Investigator Award from the Division of Chemical Toxicology of the American Chemical Society (2012), and the 2013 Biemann Medal from the American Society for Mass Spectrometry. He was also named the Yangtze River Scholars Distinguished Professor in 2016. Yinsheng was a standing member for the Cancer Etiology study section in 2011-2015 and for the Environmental Health Sciences study section since 2016. Yinsheng organized multiple symposia for the Division of Chemical Toxicology at annual ACS National Meetings, and he also served as the treasurer for the Division in 2014-2015. In addition, he has been a member for the editorial advisory board for Chemical Research in Toxicology since 2007.

The TOXI Division presents awards to the top presentations and poster for students and post-docs.  Congratulations to these young scientists.

Top Oral Presentation.

Madjda Bellamri, Robert J. Turesky University of Minnesota
Mechanism of bioactivation of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human prostate

Graduate student presentations

First Place

Stephanie Bamberger, Hope Pan, Ryan Bowen, Chanchal Kumar Malik, Tracy Johnson-Salyard, Carmelo Rizzo, Michael P. Stone. Vanderbilt University
Characterization of the 2,6-diamino-4-hydroxy-N5-(methyl)-formamidopyrimidine DNA lesion

Second Place

Daniel J. Laverty, Marc M. Greenberg. Johns Hopkins University
Abasic and oxidized abasic lesion bypass by DNA polymerase theta yields one- and two-nucleotide deletions

Post-doc Poster Presentations

First Place

Hong Mu, Nicholas E. Geacintov, Yingkai Zhang, Suse Broyde. New York University,
Lesion recognition in nucleotide excision repair: Relationship between the structural properties of adducts and initial binding of XPC to the damaged site

Scond Place

Kun Yang, Marc M. Greenberg. Johns Hopkins University.
Histone protein tails inhibit depurination of N7-methylated deoxyguanosine and form DNA-protein crosslinks with alkylated DNA in nucleosome core particles

Third Place

QingQing Wang, Liwei Weng, Clementina Mesaros, Ian A. Blair. University of Pennsylvania Absolute quantification of plasma fibulin-3 as a biomarker for asbestos exposure by immunoprecipitation-high resolution mass spectrometry

Graduate Student Poster Presentations

First Place

Jessica Murray, Meng Huang, Clementina Mesaros, Volker Arlt, Karam El Bayoumy, Ian A. Blair, Trevor M. Penning. University of Pennsylvania
Nrf2-Keap1 signaling and implications for the metabolic activation of nitroarenes

Second Place

Shaofei Ji, Orlando Scharer, Natalia Y. Tretyakova. University of Minnesota.
Polymerase bypass of DNA-protein and DNA-peptide cross-links

Third Place

Orrette R. Wauchope, Michelle M. Mitchener, William N. Beavers, James Galligan, Philip Kingsley, Ha-Na Shim, Thomas Blackwell, Thong Luong, Mark deCaestecker, Joshua P. Fessel, Lawrence J. Marnett. Vanderbilt University.
Mitochondrial M1dG levels linked to oxidative stress and mito

ACS Fellows 2018 Class.

Now is the time to nominate members of the Division to become ACS Fellows. These nominations can be made by individuals or by the TOXI Division. Divisional nominations made by the Chair of the Division are limited to no more than 4.

The American Chemical Society Fellow  designation is awarded to a member who has made

  1. exceptional contributions to the science or profession and
  2. has provided excellent volunteer service to the ACS community.

Successful nominations need to document scientific accomplishments and service to ACS. Nominations without documentation of a considerable service component will be declined.  To learn more about the nomination process and for a list of current ACS fellows please visit: ACS Fellows Website

Contact Trevor M. Penning, Chair, Awards Committee Division of Toxicology if you would like the Division to consider a nomination at penning@upenn.edu

Contact Thomas Spratt if you would like to add another news item to this page