Division of Chemical Toxicology
The mission of the Division is to improve human health and public welfare by promoting the understanding of chemical mechanisms that govern disease processes and the toxicity of drugs, environmental agents, and endogenous chemicals. This will be accomplished by (1) providing a forum for communicating research in the field of chemical toxicology; (2) encouraging further research into chemical mechanisms of toxicity; (3) providing a rigorous scientific basis for risk assessment; (4) providing continuing education, leadership training, and career development opportunities for our fellow chemists; and (5) sponsoring with other societies and divisions, symposia and other programs of mutual interest.
Division of Chemical Toxicology News
Division of Chemical Toxicology
Translation Aspects of DNA repair
Electron flow through proteins, Harry B Gray
Competition between repair and oxidation of the endogenous DNA adduct, 3(2-deoxy-β-D-erythro-pentofuranosyl)pyrimido[1,2-α]purin-10(3H)-one (M1dG), Lawrence J Marnett
Highways for repair of heterochromatic DNA breaks, Irene Chiolo
Hyperglycemia induced DNA damage and inhibition of DNA repair- a potential mechanistic link between diabetes and increased cancer risk, John S Termini
SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts, Yilun Liu
Founders Award Symposium. The Role of Carbonyl Metabolism in Health & Disease
Histone modification by bifunctional electrophiles derived from lipid and carbohydrate metabolism, Lawrence J Marnett
Interactions of aldehydic bifunctional electrophiles and high mobility group box-1 with RAGE, Ian A Blair
Aldehyde dehydrogenases: from metabolic and alcohol-related diseases to cancer stem cells, Vasilis Vasilou
Aldo-Keto Reductases and NRF2, John D Hayes
Role of Human Aldo-Keto Reductases (AKRs) in Hormonal & Chemical Carcinogenesis, Trevor M Penning
TOXI Young Investigators
EPIGENETIC CHANGES IN ALVEOLAR TYPE II LUNG CELLS OF A/J MICE FOLLOWING EXPOSURE TO CIGARETTE SMOKE AND LPS, Jenna Fernandez
Oxidation of RNA at naturally occurring modifications, Immaculate Sappy
DNA glycosylase NEIL1 demonstrates lesion specificity from RNA editing, Elizabeth R Lotsof
Sequencing for 8-oxo-7,8-dihydroguanine in a mammalian genome before and after oxidative stress, Judy Zhu
Embryonic exposure to 2, 2’, 3, 5’, 6 polychlorinated biphenyls (PCB-95) alters GABAgenic and antioxidant transcriptome in zebrafish, Prabha Ranasinghe
Nrf2 Signaling Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone, Jessica R Murray
Interstrand cross-links at strand breaks derived from abasic sites in duplex DNA, Kurt Housh
Replicative bypass and mutagenic properties of alkylphosphotriester lesions in Escherichia coli, Jiabin Wu
Development of an Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) Assay for the Quantification of Cisplatin-Induced DNA Intra- and Interstrand Cross-Links, Arnold Groehler
High-resolution/Accurate-mass DNA Adductomics to Identify Adducts Formed by the Hypoxia-activated Alkylating Agent, CP-506 and its Metabolites, Morwena J Solivio
Identification of a new N’-nitrosonornicotine (NNN)-specific DNA adduct N6-((5-(3-pyridyl)tetrahydrofuran-2-yl)-2′-deoxyadenosine in rat liver, Yupeng Li
Current Approaches to Discovery Phase Safety Assessment in the Industry
Strategies for early safety assessment of potential drug candidates at Amgen and lessons learned, Mark Fielden
Early safety assessment strategies for drug discovery at Celgene and lessons learned, Joseph R Piccotti
Strategies towards the design of safer compounds at Takeda and lessons learned, Russell Naven
Reactive metabolism strategy applied to drug safety assessment: Focus on risk prevention, Kevin J Coe
Strategies for early safety assessment of potential drug candidates at Bristol-Myers Squibb: Preclinical evaluation of hepatobiliary toxicity,Michael Gill
Integrated Platform, Utilizing Transcriptomic Profiling and Metabolite Identification Studies, to Derisk Drug Bioactivation-Mediated Liver Injury, Kaushik Mitra
Emerging Topics in Chemical Toxicology
Delivering web-based access to data and algorithms to support computational toxicology: the US-EPA CompTox Chemicals Dashboard, Antony J Williams
DARPA’s Microphysiological Systems (MPS) Program, Bradley Ringeisen
Dare to Repair: From DNA Chemistry to Cancer, Sheila S David
E-cigarette aerosols for in vitro and in vivo toxicology studies: Key considerations, Irina Stepanov
Developing DNA repair pathway specific genotoxic signatures, Robert Sobol
CRT Young Investigator Award
Annotating the small-molecule exposome by subtraction, Gary Patti
E.coli-produced genotoxin colibactin: DNA adduct identification using untargeted adductomics and in vivo detection using high resolution mass spectrometry, Peter W Villalta
Integrative experimental modelling reveals novel genome-scale mutation fingerprints of carcinogens, Jiri Zavadil
High resolution mass spectrometry-based approaches for the investigation of chemical carcinogenesis, Silvia Balbo
Brian R. Berridge,
Epigenetic Response to Endogenous & Exogenous Toxins
Epigenetic Regulation via Oxidized Forms of MeC and Inflammation-Mediated Epigenetic Deregulation, Natalia Y Tretyakova
Reversible Histone Glycation Drives Disease- Associated Changes in Chromatin Architecture, Yael David
Base modifications in DNA non-canonical structures regulate transcription, Aaron M Fleming
Transcription-coupled recognition of DNA lesions and endogenous epigenetic modifications, Dong Wang
Targeted quantitative proteomic approaches toward understanding epitranscriptomic regulations, Yinsheng Wang
Topics in Chemical Toxicology
Genome-wide CRISPR Screening to identify modulators of Formaldehyde Toxicity in Erythroid cells, Chris Vulpe
Higher advanced oxidative modifications in hemoglobin of oral cancer patients as measured by nanoflow liquid chromatography tandem mass spectrometry, Hauh-Jyun C. Chen
Competitive binding of human DNA glycosylase hNEIL1 and DNA damage-sensing factor XPC-RAD23B to oxidatively generated guanine lesions, Vladimir Shafirovich
Probing Chemical Biology of DNA Damage using NMR, Michael P. Stone
Molecular Modeling of Genotoxic Azo dyes , Sudan I and Sudan II , and Their Metabolites, Rachelle J. Bienstock
Comprehensive toxicity information of every chemical for better R&D decisions, Neelam Vaidya
Emission of Respirable Particles from Fused Deposition Modeling 3D Printers, Peter Byrley
Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines, Gunnar Boysen
Carbon dioxide enhances the pulmonary tumorigenic activity of the tobacco specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), Lisa A. Peterson
The magic of the Chemosynthetic Livers Which is the best porphyrin, Mukund Chorghade
Oxidative decarboxylation of 2–oxoacids by hydroperoxides can be used to lower peroxide values in citrus oils, Michael J. Calandra
Trevor Penning is currently Thelma Brown and Henry Charles Molinoff Professor of Pharmacology Molinoff Professor in the Department of Systems Pharmacology & Translational Therapeutics at the University of Pennsylvania Perelman School of Medicine. He is also Director of the Center of Excellence in Environmental Toxicology (CEET).
He belongs to the Johns Hopkins Society of Scholars and is a Fellow of the American Chemical Society.
Trevor has performed outstanding research in the areas of chemical toxicology and environmental science with over 500 publication. His research interest is in the role of aldo-keto reductases (AKRs) in intracrine hormone biosynthesis as it relates to prostate and breast cancer; and the development of inhibitors for said enzymes as chemical probes and therapeutics. He curates www.med.upenn.edu/akr which provides scientists information about the AKR superfamily of proteins. To learn more about Trevor’s research, visit his lab website
Trevor has provided outstanding and sustained service to the Division of Chemical Toxicology. He was Program Committee Chair (2 years); Chair of Division (2 years); Chair of the Awards Committee (2 years); and he has been a member of the Executive Committee (8 years); a Symposium Organizer and regular Symposium Speaker. He was also a chartered member of the Cancer Etiology Study Section at NIH for 5 years and provided grant review service to the Division of Toxicology members in this role. He is now Senior Editor for Cancer Research for Population and Prevention Science. He has been a member of two working groups at IARC, which re-assessed the carcinogenicity of PAH, and diesel exhaust.
Trevor Penning will be honored at the American Chemical Society Meeting in San Diego this August with a Symposium in his honor.
Speaking at the symposium will be :
Larry J. Marnett, Vanderbilt University.
Ian A. Blair, University of Pennsylvania
Vasilis Vasilou, Yale University
John D. Hayes, Ninewells Hospital, University of Dundee
Trevor M. Penning, University of Pennsylvania
My two-year term as the Chair of the ACS Division of Chemical Toxicology (TOXI) expired on December 31, 2018. Shana
Sturla, Professor of Toxicology at ETH, Zürich, and the new Editor-in-Chief of the journal Chemical Research in Toxicology, succeeds me in this position for a two-year term. It has been my pleasure to serve in that capacity with some wonderful people in the TOXI Executive Committee and the membership who generously gave their time and energy to foster the interests of our Division.
This past year, the annual meeting of the TOXI Division was held in historic Boston. The highlights of the meeting are discussed in the most recent TOXI Newsletter. Here, I will focus on other divisional news and activities.
In conjunction with the Division’s Executive Committee, we restructured the appointment schedules of our Program Chairs who have the responsibility of organizing our annual scientific meetings. These meetings represent one of the most important activities of our Division. They offer us opportunities for learning about different topics in chemical toxicology, and to meet face-to-face with colleagues and friends to discuss topics of mutual interest. Even those who are unable to attend these meetings, can view the program listings online and browse through ~ 90 – 100 TOXI abstracts.
Tom Spratt has been the Program Chair and organizer for the past two TOXI meetings (2017 and 2018), and will continue in this position for another year in 2019. A Program Committee consisting of five senior TOXI members assists the Program Chair in planning the contents of the meetings and to offer other advice as necessary. This year, the TOXI leadership decided to reorganize the appointment schedules to ensure the smooth transitions from one Program Chair to another. Two Program Chairs have been appointed: Penny Buening (2020-2021) is Professor of Chemistry and Chemical Biology and Northeastern University, and Michael Trakselis (2022-2023) Is Associate Professor of Chemistry and Biochemistry at Baylor University. These early appointments ensure the continuity of this most important science programming activity at least until the end of 2023. Each Program Chair will serve as the Program co-chair in the preceding two years in order to become familiar with the demands of this position before they assume the full responsibility that comes with it.
One of the important and ongoing efforts of our Division is to include a larger cross-section of the members in leadership activities and functions. In order to better engage younger members in the affairs of our Division, a Program Development Committee (PDC) was organized. The PDC members are appointed (11 members) that include Ujjal Sarkar (AstraZeneca) who helped me to organize this Committee. The new PDC committee has already made significant contributions by suggesting topics for future annual meetings, and by helping Tom during the 2018 meeting in Boston; they chaired some of the sessions, and helped to select the best poster and oral presentations at the Young Investigator Symposium. Thanks to a generous donation from Fred and Suan Beland, the TOXI Division was able to partially support the travel of eight young investigators (graduate students and postdocs) to the 2018 TOXI Boston meeting.
A highlight of this past year included the selection of Judy Bolton as the winner of the 2018 ACS Division of Chemical Toxicology Founders Award. Judy is the head of the Medicinal Chemistry and Pharmacognosy Departm
ent at the University of Illinois at Chicago, and has a long and distinguished research record in various areas of chemical toxicology,
hormonal carcinogenesis, and chemoprevention related to post-menopausal women’s health issues. Recently, she has been focusing on the effects of botanical supplements in the treatment of menopause symptoms and cancer prevention, which was the topic of her Award lecture at the 2018 Boston meeting. Related to this event, Judy was interviewed by Chemical & Engineering News (September 3, 2018 issue), and authored an exciting forthcoming review in Chemical Research in Toxicology regarding molecular targets of hops compounds as natural alternatives to traditional hormone therapy for relieving menopausal symptoms. link to paper
In closing, I extend my best wishes to Shana for a successful two years as TOXI Chair. I am sure that she will be very successful. I look forward to serving these two years as the Past Chair and as a member of the Executive Committee.
Past Chair, Division of Chemical Toxicology
ACS Fellows 2020 Class.
Now is the time to nominate members of the Division to become ACS Fellows. These nominations can be made by individuals or by the TOXI Division. Divisional nominations made by the Chair of the Division are limited to no more than 4.
The American Chemical Society Fellow designation is awarded to a member who has made
- exceptional contributions to the science or profession and
- has provided excellent volunteer service to the ACS community.
Successful nominations need to document scientific accomplishments and service to ACS. Nominations without documentation of a considerable service component will be declined. To learn more about the nomination process and for a list of current ACS fellows please visit: ACS Fellows Website
Contact Kent Gates, Chair, Awards Committee Division of Toxicology if you would like the Division to consider a nomination at email@example.com
Travel Awards to the 258th ACS Meeting in San Diego.
Travel awards for students and post-docs will be available for the TOXI Program at the ACS Meeting in San Diego. The students and post-docs will receive up to $750 to help pay for their travel expenses to the ACS Meeting.
The student must
- be presenting a poster or talk at the TOXI program
- be a TOXI member. (You can join now. Download application and follow instructions)
The application should consist of a single pdf file containing:
1. A nomination letter from the faculty advisor or laboratory director. The letter should explain why Travel Assistance Award funds are needed.
2. A curriculum vitae for the applicant.
3. The abstract for the work to be presented by the nominee at the meeting.
Applications can be submitted to Dr. Thomas Spratt at firstname.lastname@example.org by May 1.
Brian Berridge, the Associate Director of the US National Toxicology Program will present the Keynote Address for the Division of Chemical Toxicology on Tuesday August 27, 2018. His title will be “Embracing translation in toxicology: National toxicology program strategy.”
Dr Berridge joined the National Toxicology Program in January of 2018. where he oversees day-to-day operations as NTP coordinates toxicology research and testing across nine different federal agencies, including the National Institutes of Health, the U.S. Food and Drug Administration, and the Centers for Disease Control and Prevention.
His goal is to enable NTP to take the detailed mechanistic data generated by methods like high-throughput toxicology screening and understand what that means to a patient, a person, and a population.