Division of Chemical Toxicology
The mission of the Division is to improve human health and public welfare by promoting the understanding of chemical mechanisms that govern disease processes and the toxicity of drugs, environmental agents, and endogenous chemicals. This will be accomplished by (1) providing a forum for communicating research in the field of chemical toxicology; (2) encouraging further research into chemical mechanisms of toxicity; (3) providing a rigorous scientific basis for risk assessment; (4) providing continuing education, leadership training, and career development opportunities for our fellow chemists; and (5) sponsoring with other societies and divisions, symposia and other programs of mutual interest.
Division of Chemical Toxicology News
Division of Chemical Toxicology
Translation Aspects of DNA repair
Electron flow through proteins, Harry B Gray
Competition between repair and oxidation of the endogenous DNA adduct, 3(2-deoxy-β-D-erythro-pentofuranosyl)pyrimido[1,2-α]purin-10(3H)-one (M1dG), Lawrence J Marnett
Highways for repair of heterochromatic DNA breaks, Irene Chiolo
Hyperglycemia induced DNA damage and inhibition of DNA repair- a potential mechanistic link between diabetes and increased cancer risk, John S Termini
SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts, Yilun Liu
Founders Award Symposium. The Role of Carbonyl Metabolism in Health & Disease
Histone modification by bifunctional electrophiles derived from lipid and carbohydrate metabolism, Lawrence J Marnett
Interactions of aldehydic bifunctional electrophiles and high mobility group box-1 with RAGE, Ian A Blair
Aldehyde dehydrogenases: from metabolic and alcohol-related diseases to cancer stem cells, Vasilis Vasilou
Aldo-Keto Reductases and NRF2, John D Hayes
Role of Human Aldo-Keto Reductases (AKRs) in Hormonal & Chemical Carcinogenesis, Trevor M Penning
TOXI Young Investigators
EPIGENETIC CHANGES IN ALVEOLAR TYPE II LUNG CELLS OF A/J MICE FOLLOWING EXPOSURE TO CIGARETTE SMOKE AND LPS, Jenna Fernandez
Oxidation of RNA at naturally occurring modifications, Immaculate Sappy
DNA glycosylase NEIL1 demonstrates lesion specificity from RNA editing, Elizabeth R Lotsof
Sequencing for 8-oxo-7,8-dihydroguanine in a mammalian genome before and after oxidative stress, Judy Zhu
Embryonic exposure to 2, 2’, 3, 5’, 6 polychlorinated biphenyls (PCB-95) alters GABAgenic and antioxidant transcriptome in zebrafish, Prabha Ranasinghe
Nrf2 Signaling Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone, Jessica R Murray
Interstrand cross-links at strand breaks derived from abasic sites in duplex DNA, Kurt Housh
Replicative bypass and mutagenic properties of alkylphosphotriester lesions in Escherichia coli, Jiabin Wu
Development of an Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) Assay for the Quantification of Cisplatin-Induced DNA Intra- and Interstrand Cross-Links, Arnold Groehler
High-resolution/Accurate-mass DNA Adductomics to Identify Adducts Formed by the Hypoxia-activated Alkylating Agent, CP-506 and its Metabolites, Morwena J Solivio
Identification of a new N’-nitrosonornicotine (NNN)-specific DNA adduct N6-((5-(3-pyridyl)tetrahydrofuran-2-yl)-2′-deoxyadenosine in rat liver, Yupeng Li
Current Approaches to Discovery Phase Safety Assessment in the Industry
Strategies for early safety assessment of potential drug candidates at Amgen and lessons learned, Mark Fielden
Early safety assessment strategies for drug discovery at Celgene and lessons learned, Joseph R Piccotti
Strategies towards the design of safer compounds at Takeda and lessons learned, Russell Naven
Reactive metabolism strategy applied to drug safety assessment: Focus on risk prevention, Kevin J Coe
Strategies for early safety assessment of potential drug candidates at Bristol-Myers Squibb: Preclinical evaluation of hepatobiliary toxicity,Michael Gill
Integrated Platform, Utilizing Transcriptomic Profiling and Metabolite Identification Studies, to Derisk Drug Bioactivation-Mediated Liver Injury, Kaushik Mitra
Emerging Topics in Chemical Toxicology
Delivering web-based access to data and algorithms to support computational toxicology: the US-EPA CompTox Chemicals Dashboard, Antony J Williams
DARPA’s Microphysiological Systems (MPS) Program, Bradley Ringeisen
Dare to Repair: From DNA Chemistry to Cancer, Sheila S David
E-cigarette aerosols for in vitro and in vivo toxicology studies: Key considerations, Irina Stepanov
Developing DNA repair pathway specific genotoxic signatures, Robert Sobol
CRT Young Investigator Award
Annotating the small-molecule exposome by subtraction, Gary Patti
E.coli-produced genotoxin colibactin: DNA adduct identification using untargeted adductomics and in vivo detection using high resolution mass spectrometry, Peter W Villalta
Integrative experimental modelling reveals novel genome-scale mutation fingerprints of carcinogens, Jiri Zavadil
High resolution mass spectrometry-based approaches for the investigation of chemical carcinogenesis, Silvia Balbo
Brian R. Berridge,
Epigenetic Response to Endogenous & Exogenous Toxins
Epigenetic Regulation via Oxidized Forms of MeC and Inflammation-Mediated Epigenetic Deregulation, Natalia Y Tretyakova
Reversible Histone Glycation Drives Disease- Associated Changes in Chromatin Architecture, Yael David
Base modifications in DNA non-canonical structures regulate transcription, Aaron M Fleming
Transcription-coupled recognition of DNA lesions and endogenous epigenetic modifications, Dong Wang
Targeted quantitative proteomic approaches toward understanding epitranscriptomic regulations, Yinsheng Wang
Topics in Chemical Toxicology
Genome-wide CRISPR Screening to identify modulators of Formaldehyde Toxicity in Erythroid cells, Chris Vulpe
Higher advanced oxidative modifications in hemoglobin of oral cancer patients as measured by nanoflow liquid chromatography tandem mass spectrometry, Hauh-Jyun C. Chen
Competitive binding of human DNA glycosylase hNEIL1 and DNA damage-sensing factor XPC-RAD23B to oxidatively generated guanine lesions, Vladimir Shafirovich
Probing Chemical Biology of DNA Damage using NMR, Michael P. Stone
Molecular Modeling of Genotoxic Azo dyes , Sudan I and Sudan II , and Their Metabolites, Rachelle J. Bienstock
Comprehensive toxicity information of every chemical for better R&D decisions, Neelam Vaidya
Emission of Respirable Particles from Fused Deposition Modeling 3D Printers, Peter Byrley
Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines, Gunnar Boysen
Carbon dioxide enhances the pulmonary tumorigenic activity of the tobacco specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), Lisa A. Peterson
The magic of the Chemosynthetic Livers Which is the best porphyrin, Mukund Chorghade
Oxidative decarboxylation of 2–oxoacids by hydroperoxides can be used to lower peroxide values in citrus oils, Michael J. Calandra
Trevor Penning is currently Thelma Brown and Henry Charles Molinoff Professor of Pharmacology Molinoff Professor in the Department of Systems Pharmacology & Translational Therapeutics at the University of Pennsylvania Perelman School of Medicine. He is also Director of the Center of Excellence in Environmental Toxicology (CEET).
He belongs to the Johns Hopkins Society of Scholars and is a Fellow of the American Chemical Society.
Trevor has performed outstanding research in the areas of chemical toxicology and environmental science with over 500 publication. His research interest is in the role of aldo-keto reductases (AKRs) in intracrine hormone biosynthesis as it relates to prostate and breast cancer; and the development of inhibitors for said enzymes as chemical probes and therapeutics. He curates www.med.upenn.edu/akr which provides scientists information about the AKR superfamily of proteins. To learn more about Trevor’s research, visit his lab website
Trevor has provided outstanding and sustained service to the Division of Chemical Toxicology. He was Program Committee Chair (2 years); Chair of Division (2 years); Chair of the Awards Committee (2 years); and he has been a member of the Executive Committee (8 years); a Symposium Organizer and regular Symposium Speaker. He was also a chartered member of the Cancer Etiology Study Section at NIH for 5 years and provided grant review service to the Division of Toxicology members in this role. He is now Senior Editor for Cancer Research for Population and Prevention Science. He has been a member of two working groups at IARC, which re-assessed the carcinogenicity of PAH, and diesel exhaust.
Trevor Penning will be honored at the American Chemical Society Meeting in San Diego this August with a Symposium in his honor.
Speaking at the symposium will be :
Larry J. Marnett, Vanderbilt University.
Ian A. Blair, University of Pennsylvania
Vasilis Vasilou, Yale University
John D. Hayes, Ninewells Hospital, University of Dundee
Trevor M. Penning, University of Pennsylvania
My two-year term as the Chair of the ACS Division of Chemical Toxicology (TOXI) expired on December 31, 2018. Shana
Sturla, Professor of Toxicology at ETH, Zürich, and the new Editor-in-Chief of the journal Chemical Research in Toxicology, succeeds me in this position for a two-year term. It has been my pleasure to serve in that capacity with some wonderful people in the TOXI Executive Committee and the membership who generously gave their time and energy to foster the interests of our Division.
This past year, the annual meeting of the TOXI Division was held in historic Boston. The highlights of the meeting are discussed in the most recent TOXI Newsletter. Here, I will focus on other divisional news and activities.
In conjunction with the Division’s Executive Committee, we restructured the appointment schedules of our Program Chairs who have the responsibility of organizing our annual scientific meetings. These meetings represent one of the most important activities of our Division. They offer us opportunities for learning about different topics in chemical toxicology, and to meet face-to-face with colleagues and friends to discuss topics of mutual interest. Even those who are unable to attend these meetings, can view the program listings online and browse through ~ 90 – 100 TOXI abstracts.
Tom Spratt has been the Program Chair and organizer for the past two TOXI meetings (2017 and 2018), and will continue in this position for another year in 2019. A Program Committee consisting of five senior TOXI members assists the Program Chair in planning the contents of the meetings and to offer other advice as necessary. This year, the TOXI leadership decided to reorganize the appointment schedules to ensure the smooth transitions from one Program Chair to another. Two Program Chairs have been appointed: Penny Buening (2020-2021) is Professor of Chemistry and Chemical Biology and Northeastern University, and Michael Trakselis (2022-2023) Is Associate Professor of Chemistry and Biochemistry at Baylor University. These early appointments ensure the continuity of this most important science programming activity at least until the end of 2023. Each Program Chair will serve as the Program co-chair in the preceding two years in order to become familiar with the demands of this position before they assume the full responsibility that comes with it.
One of the important and ongoing efforts of our Division is to include a larger cross-section of the members in leadership activities and functions. In order to better engage younger members in the affairs of our Division, a Program Development Committee (PDC) was organized. The PDC members are appointed (11 members) that include Ujjal Sarkar (AstraZeneca) who helped me to organize this Committee. The new PDC committee has already made significant contributions by suggesting topics for future annual meetings, and by helping Tom during the 2018 meeting in Boston; they chaired some of the sessions, and helped to select the best poster and oral presentations at the Young Investigator Symposium. Thanks to a generous donation from Fred and Suan Beland, the TOXI Division was able to partially support the travel of eight young investigators (graduate students and postdocs) to the 2018 TOXI Boston meeting.
A highlight of this past year included the selection of Judy Bolton as the winner of the 2018 ACS Division of Chemical Toxicology Founders Award. Judy is the head of the Medicinal Chemistry and Pharmacognosy Departm
ent at the University of Illinois at Chicago, and has a long and distinguished research record in various areas of chemical toxicology,
hormonal carcinogenesis, and chemoprevention related to post-menopausal women’s health issues. Recently, she has been focusing on the effects of botanical supplements in the treatment of menopause symptoms and cancer prevention, which was the topic of her Award lecture at the 2018 Boston meeting. Related to this event, Judy was interviewed by Chemical & Engineering News (September 3, 2018 issue), and authored an exciting forthcoming review in Chemical Research in Toxicology regarding molecular targets of hops compounds as natural alternatives to traditional hormone therapy for relieving menopausal symptoms. link to paper
In closing, I extend my best wishes to Shana for a successful two years as TOXI Chair. I am sure that she will be very successful. I look forward to serving these two years as the Past Chair and as a member of the Executive Committee.
Past Chair, Division of Chemical Toxicology
The candidate will serve as Chair-Elect in 2019-2020, Chair in 2021-2022, and Immediate Past-Chair in 2023-2024.
Natalia Tretyakova is currently McKnight Distinguished University Professor and Director of the Epigenetics Consortium at the University of Minnesota-Twin Cities. Dr. Tretyakova’s research in chemical toxicology is primarily focused on chemical carcinogenesis, DNA-protein cross-linking, and epigenetic effects of environmental exposures and inflammation. She employs mass spectrometry based methodologies to investigate the mechanisms of epigenetic deregulation and cancer causing mutations associated with environmental exposure and lifestyle factors. Professor Tretyakova has pioneered novel methodologies to detect DNA damage, evaluated the ability of altered DNA bases to induce genetic mutations, and developed DNA based biomarkers of cancer risk. Her work has advanced our understanding of the role of DNA damage in human disease, informing future strategies for improving human health. Dr Tretyakova published 112 peer-reviewed publications and She mentored over 22 Ph.D.s and 15 postdoctoral fellows. She just finished her term as Treasurer of the ACS Division of Chemical Toxicology.
The candidate will serve as one of the three Members-at-Large on the executive council for a three-year term.
Robert Turesky is a Professor in the Department of Medicinal Chemistry and Director of the Masonic Cancer Center’s Analytical Biochemistry shared resource (2013 – present), a mass spectrometry facility devoted to the cancer and chemoprevention programs at the University of Minnesota. Dr. Turesky received his B.Sc. in biochemistry from the University of Massachusetts, Amherst, and PhD in nutrition and food science from M.I.T. Prior to this position, Dr. Turesky was Group Leader of the Biomarkers Unit, Nestlé Research Center, Lausanne, Switzerland (1986 – 2000); Division Director of Chemistry, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, (2000 – 2004); and Principal Investigator, Wadsworth Center, New York State Department of Health (2004 – 2013). His research is focused on the biochemical toxicology of dietary and environmental toxicants. He has developed mass spectrometric-based methods to measure biomarkers of these genotoxicants designed to understand the role of chemical exposures in the etiology of human cancers. Novel technologies and MS-based approaches have been established to identify DNA adducts of carcinogens in formalin fixed paraffin embedded tissues and exfoliated urinary cells, two biospecimens largely underutilized in cancer biomarker research. These bioanalytical approaches are expected to provide important new data on the chemicals that damage the genome and contribute to cancer etiology. He has published more than 200 scientific papers in leading journals and book chapters. He has served as Secretary of the Division of Chemical Toxicology (2001 – 2002) and Member at Large (2013 – 2015). He has been a member of the Editorial Advisory Board of Chemical Research in Toxicology 1996 -2002, 2010 – present).
The candidate will serve a three year term on the Nominating Committee from 2019-2021. In 2021, the candidate will serve a chair of the committee
Lawrence J. Marnett, Ph.D., is Dean of Basic Sciences of the School of Medicine, University Professor, Mary Geddes Stahlman Professor of Cancer Research, and Professor of Biochemistry, Chemistry, and Pharmacology at Vanderbilt University. Marnett received his Ph.D. in Chemistry from Duke University and did postdoctoral work at the Karolinska Institute and Wayne State University. He began his academic career at Wayne State University then moved to Vanderbilt in 1989. Marnett’s research program focuses on the role of bioactive lipids in cancer and inflammation. He is the author of over 500 research publications and 14 patents and has received an American Cancer Society Faculty Research Award, an Outstanding Investigator Award and a MERIT Award from the National Cancer Institute. He is a Fellow of the American Association for the Advancement of Science and a Fellow of the American Chemical Society. He was the first winner of the Founders Award from the Division of Chemical Toxicology and the first winner of the George and Christine Sosnovsky Award for Cancer Research from the American Chemical Society. At Vanderbilt, he was named a Harvey Branscomb Professor and won the Stanley Cohen Prize. He was the Founding Editor-in-Chief of Chemical Research in Toxicology from 1988-2012
ACS Fellows 2019 Class.
Now is the time to nominate members of the Division to become ACS Fellows. These nominations can be made by individuals or by the TOXI Division. Divisional nominations made by the Chair of the Division are limited to no more than 4.
The American Chemical Society Fellow designation is awarded to a member who has made
- exceptional contributions to the science or profession and
- has provided excellent volunteer service to the ACS community.
Successful nominations need to document scientific accomplishments and service to ACS. Nominations without documentation of a considerable service component will be declined. To learn more about the nomination process and for a list of current ACS fellows please visit: ACS Fellows Website
Contact Kent Gates, Chair, Awards Committee Division of Toxicology if you would like the Division to consider a nomination at firstname.lastname@example.org
Travel Awards to the 258th ACS Meeting in San Diego.
Travel awards for students and post-docs will be available for the TOXI Program at the ACS Meeting in San Diego. The students and post-docs will receive up to $750 to help pay for their travel expenses to the ACS Meeting.
The student must
- be presenting a poster or talk at the TOXI program
- be a TOXI member. (You can join now. Download application and follow instructions)
The application should consist of a single pdf file containing:
1. A nomination letter from the faculty advisor or laboratory director. The letter should explain why Travel Assistance Award funds are needed.
2. A curriculum vitae for the applicant.
3. The abstract for the work to be presented by the nominee at the meeting.
Applications can be submitted to Dr. Thomas Spratt at email@example.com by May 1.
John Essigmann will present the Keynote lecture on Tuesday afternoon, August 21, 2018 during the TOXI program at the American Chemical Society National Convention in Boston. John is the William R. (1956) and Betsy P. Leitch Professor in Residence of Chemistry in the MIT Department of Chemistry. He is also Professor of Toxicology and Biological Engineering in the MIT Department of Biological Engineering. In addition, he is Director of the MIT Center for Environmental Health Sciences.
John earned a BS in Chemistry at Northeastern University and a PhD from MIT under the direction of Gerald Wogan, a pioneer in the field of chemical toxicology.
The overarching theme in John’s research is to understand how DNA damage leads to cancer and cell death. In particular, he strives to understand how the chemical and physical properties of specific DNA adducts lead to mutagenesis or cell death. He then uses this knowledge to design antitumor drugs in a process described as Fatal Engineering.
John’s lab was the first to synthesize and insert a single DNA adduct at a specific site in DNA in a cell. This revolutionary process has lead to his lab and, many others, probe the effects of specific DNA adducts to mutagenesis and lethality. In addition, the DNA damage response to these adducts have been identified.
John’s has used the knowledge gained in his mechanistic studies to design programmable antitumor drugs through a process described as Fatal Engineering. The Essigmann lab exploits the presence of tumor specific proteins, so that repair of the DNA adduct derived from the drug will occur in normal cells but fail in tumor cells. Thus the programmable drug kills tumor but not normal cells.