Home

Division of Chemical Toxicology

The mission of the Division is to improve human health and public welfare by promoting the understanding of chemical mechanisms that govern disease processes and the toxicity of drugs, environmental agents, and endogenous chemicals. This will be accomplished by (1) providing a forum for communicating research in the field of chemical toxicology; (2) encouraging further research into chemical mechanisms of toxicity; (3) providing a rigorous scientific basis for risk assessment; (4) providing continuing education, leadership training, and career development opportunities for our fellow chemists; and (5) sponsoring with other societies and divisions, symposia and other programs of mutual interest.

Division of Chemical Toxicology News

Sunday Aug 16, 2020

TOXI Young Investigators Symposium

Organizers: Erin Prestwich and Ujjal Sarkar
TOXI 1. 8:05 AM. Geisen, Susanne. Chemical mechanism of O6-carboxymethyldeoxyguanine formation from azaserine and abundance in cells [Abstract]
TOXI 2. 8:25 AM. Li, Yupeng. Investigation of 2′-Deoxyadenosine-derived adducts specifically formed in rat liver by N’-nitrosonornicotine (NNN) metabolism [Abstract]
TOXI 3. 8:45 AM. Terrell, John. Covalent binding of anthracyclines to AP sites in DNA suggest an unstudied mechanism of cytotoxicity from chemotherapeutic regimens [Abstract]
TOXI 4. 9:05 AM. Ahmed, C. M. Sabbir. Integrative analysis of lncRNA-mRNA co-expression in human lung epithelial cells exposed to dimethyl selenide (DMSe)-derived secondary organic aerosols [Abstract]
TOXI 5. 9:25 AM. Li, Miao. Development of the generic pregnancy physiologically based pharmacokinetic (PBPK) model to support regulatory evaluations of the safety and efficacy of therapeutic agents [Abstract]
TOXI 6. 10:05 AM. Demir, Merve. Fishing for OG lesions: Structural and biochemical insights into OG detection by MutY [Abstract]
TOXI 7. 10:25 AM. Hurley, Katherine. Biosynthesis of acrolein with a coupled enzyme system to emulate continuous acrolein production by gut microbiota [Abstract]
TOXI 8. 10:45 AM. Pujari, Suresh. Synthesis, structural confirmation, and detection of EB-FAPy-dG and DEB-FAPy-dG adducts in human cells [Abstract]
TOXI 9. 11:05 AM. Cranford, Matthew. Locating the second polymerase switch: Where resumption of replication limits the length of translesion synthesis [Abstract]
TOXI 10. 11:25 AM. Wu, Junzhou. Derivatization of Phosphorothioate DNA modifications by direct chemical conjugation [Abstract]

Sunday Aug 16, 2020

Founders Award

Organizers: Pete Dedon
TOXI 11. 1:35 PM. Jaffrey, Samie. Chemical methods for detecting and quantifying nucleotide modifications in mRNA [Abstract]
TOXI 12. 2:15 PM. Begley, Thomas. Epitranscriptomic marks translationally regulate stress response programs to protect against environmental insults [Abstract]
TOXI 13. 3:15 PM. Gregory, Richard. Role of the ‘Epitranscriptome’ in gene regulation and cancer [Abstract]
TOXI 14. 4:00 PM. Dedon, Peter. Old becomes new in the epi-verse of DNA and RNA modifications [Abstract]

Monday Aug 17, 2020

Toxicology of Antibody-Drug Conjugates

Organizers: Sanjeev Gangwar and Michael Trakselis
TOXI 15. 8:00 AM. Bertozzi, Carolyn. Multifunctional biologics for extracellular targeted degradation [Abstract]
TOXI 16. 8:40 AM. Senter, Peter. Potent antibody-based conjugates for cancer therapy: From early stage research to clinically approved drugs and beyond [Abstract]
TOXI 17. 9:30 AM. Schutten, Melissa. Investigating nonclinical strategies to modify PBD Antibody Drug Conjugate-related toxcities [Abstract]
TOXI 18. 10:10 AM. Solis, Willy. Nonclinical safety evaluation of site-specific antibody-drug conjugates [Abstract]
TOXI 19. 10:50 AM. Reddy, Jagath. Insights to developing nextgen antibody drug conjugates [Abstract]

Monday Aug 17, 2020

Metabolism of Fluorinated Compounds and Safety Relevance

Organizers: Nicholas Meanwell, and Fred Guengerich
TOXI 20. 1:35 PM. Meanwell, Nicholas. Applications of fluorine in drug design [Abstract]
TOXI 21. 2:15 PM. Johnson, Benjamin. Metabolic and pharmaceutical aspects of fluorinated compounds [Abstract]
TOXI 22. 3:10 PM. Xu, Qiuwei. Assessment of defluorination of fluorinated drugs in animal models [Abstract]
TOXI 23. 3:50 PM. Jeschke, Peter. Latest generation of fluorine-containing agrochemicals [Abstract]

Tuesday Aug 18, 2020

Genome-wide Perspectives on the Formation, Repair, and Consequences of DNA Damage

Organizers: Sabrina Huber and Maureen McKeague
TOXI 24. 8:05 AM. Fleming, Aaron. Mechanistic Studies of 8-Oxoguanine in Non-canonical Structures Impacting Gene Expression [Abstract]
TOXI 25. 8:40 AM. Püllen, Nikolai. Nucleotide resolution mapping of DNA oxidation in the human genome [Abstract]
TOXI 26. 9:00 AM. McKeague, Maureen. Genome-wide distribution profiles of DNA damage [Abstract]
TOXI 27. 9:20 AM. Delaney, Sarah. Global repair fingerprinting of glycosylase activity on nucleosomes [Abstract]
TOXI 28. 10:15 AM. Essigmann, John. Mutational spectra provide insight into the mechanisms bridging DNA damage to genetic disease [Abstract]
TOXI 29. 10:50 AM. Wyrick, John. Mutational signatures induced by atypical UV photoproducts are associated with driver mutations in melanoma [Abstract]
TOXI 30. 11:25 AM. Mingard, Cécile. Polymerase ζ mutational spectrum following alkylating agent exposure [Abstract]

Tuesday Aug 18, 2020

Chemical Research in Toxicology Young Investigator Award Symposium

Organizers: Elijah Peterson
TOXI 31. 1:35 PM. Xia, Menghang. Profiling environmental chemicals using in vitro qHTS methods [Abstract]
TOXI 32. 2:15 PM. Sharma, Monita. In Vitro approaches for assessing respiratory toxicity [Abstract]
TOXI 33. 3:10 PM. Reipa, Vytas. Measurement issues in the phototoxicity of nanomaterials [Abstract]
TOXI 34. 3:55 PM. Petersen, Elijah. Advances in the reliability of nanotoxicity assays [Abstract]

Tuesday Aug 18, 2020

Keynote Lecture

Organizers: Natalia Tretyakova
TOXI 35. 5:05 PM. Burrows, Cynthia. Free radical oxidation of guanine in DNA—mutagenic or epigenetic? [Abstract]

Tuesday Aug 18, 2020

Poster Session

Organizers: Penny Beuning and Erin Prestwich
TOXI 36. 6:30 PM. Jokipii Krueger, Caitlin . Endogenous versus exogenous sources of N7-(2,3,4-trihydroxybut-1-yl) guanine and N7-(1-hydroxyl-3-buten-1-yl) guanine DNA adducts [Abstract]
TOXI 37. 6:30 PM. Fukuhara, Kiyoshi. Generation of reactive oxygen species following photoirradiation of nitromusks [Abstract]
TOXI 38. 6:30 PM. Ohno, Akiko. Application to toxicity evaluation of titanium dioxide nanoparticles based on physicochemical properties using multivariate analysis method [Abstract]
TOXI 39. 6:30 PM. Muller, Fabrice. In vitro and in silico testing strategies for predicting human liver toxicity from foodborne chemicals [Abstract]
TOXI 40. 6:30 PM. Brown, Brandon. Systematic review for DPR human health risk assessments: best practices as applied to case studies with allyl isothiocyanate, methomyl, and linuron [Abstract]
TOXI 41. 6:30 PM. Kyzer, Jillian. Investigation of the mechanism of immunologic response to chronic opioid use [Abstract]
TOXI 42. 6:30 PM. Geier, Mitra. Allyl isothiocyanate (AITC) hazard identification [Abstract]
TOXI 43. 6:30 PM. Blake, Timothy. Synthesis and reproductive toxicity of bisphenol analogs [Abstract]
TOXI 44. 6:30 PM. Jiang, Yang. Genome-wide sequencing of 5’-aldehyde lesions resulting from DNA oxidation [Abstract]
TOXI 45. 6:30 PM. Chen, Jin. Identification and toxicity evaluation of carbonyl emissions from vaping of alcohol-containing flavored e-liquids [Abstract]
TOXI 46. 6:30 PM. Liu, Jia | Jacob, Peyton. 1-(3-Pyridinyl)-1,2-dihydroxyethane (3-pyridylethylene glycol) is excreted in smokers’ urine. Evidence for metabolic epoxidation of 3-ethenylpyridine from inhaled tobacco smoke [Abstract]
TOXI 47. 6:30 PM. Fairman, Kiara. Contribution of parameter sensitivities to the predictive potential of pregnancy-induced pharmacokinetic changes for antihypertensives using physiologically based pharmacokinetic (PBPK) modeling [Abstract]
TOXI 48. 6:30 PM. DeMott, Michael. Phosphorothioate DNA modification in human gut microbiome [Abstract]
TOXI 49. 6:30 PM. Stornetta, Alessia. Analysis of double-stranded oligodeoxynucleotides crosslinked by the bacterial genotoxin colibactin using HILIC chromatography and high-resolution mass spectrometry [Abstract]
TOXI 50. 6:30 PM. Chen, Yitzai | Li, Deyu. Sequence effects of 4-aminobiphenyl DNA lesion-induced mutational spectra [Abstract]
TOXI 51. 6:30 PM. Wang, Jie | Li, Deyu. Structure and mutagenicity of cinnamaldehyde-induced DNA adducts [Abstract]
TOXI 52. 6:30 PM. Sun, Jingjing. Molecular beacon reporters of substrate specificity of DNA 8-oxoguanine glycosylase mutants [Abstract]
TOXI 53. 6:30 PM. Petersen, Elijah. Using a measurement science approach to Increase confidence in the EASA skin sensitization assay [Abstract]
TOXI 54. 6:30 PM. Bellamri, Medjda. Cytotoxicity and genotoxicity of tobacco smoke carcinogens in human bladder cells [Abstract]
TOXI 55. 6:30 PM. Li, Yupeng. Identification of N’-Nitrosonornicotine (NNN)-specific DNA Adduct N6-[4-Hydroxy-1-(pyridine-3-yl)butyl]-2′-deoxyadenosine in Rat Liver [Abstract]
TOXI 56. 6:30 PM. Guo, Jingshu. Development of DNA Adductome Mass Spectral Database [Abstract]
TOXI 57. 6:30 PM. Oketola, Adebola. Human exposure risk to dioxin-like PCBs in Nigeria [Abstract]
TOXI 58. 6:30 PM. Narang, Ajit. Difficult path to simple: enabling discovery to development transition [Abstract]
TOXI 59. 6:30 PM. Thorp, Clare. Development of a framework for evidence-based risk assessment of potential carcinogens in human diets [Abstract]
TOXI 60. 6:30 PM. Bacurio, Jan Henric. Translesion synthesis of Fapy-dG in human cells is dependent on DNA sequence contexts [Abstract]

Wednesday Aug 19, 2020

Chemical Exposures and Impact on Health

Organizers: Rob Turesky and Sarah Shuck
TOXI 61. 8:05 AM. Pennell, Kurt. Application of high-resolution mass spectrometry for assessment of environmental exposures and metabolic responses [Abstract]
TOXI 62. 8:45 AM. DeWitt, Jamie. Mechanisms of toxicity for per- and polyfluoroalkyl substances: Are we there yet? [Abstract]
TOXI 63. 9:25 AM. Sobus, Jon. EPA’s research initiatives on non-targeted analyses of environmental chemicals [Abstract]
TOXI 64. 10:20 AM. Lein, Pamela. Sulfated persistent organic pollutants (POPs): mechanistic studies of an emerging class of neurotoxic chemicals [Abstract]
TOXI 65. 11:00 AM. Balshaw, David. NIEHS efforts in exposure science and the exposome [Abstract]

Wednesday Aug 19, 2020

Topics in Chemical Toxicology

Organizers: Linlin Zhao and Penny Beuning
TOXI 66. 1:00 PM. Turesky, Robert. Targeted and untargeted screening of DNA adducts in the genome of prostate cancer patients [Abstract]
TOXI 67. 1:20 PM. Boysen, Gunnar. Detection and discrimination of DNA adducts differing in size, regiochemistry and functional group by nanopore sequencing [Abstract]
TOXI 68. 1:40 PM. Peterson, Lisa. Acrolein increases the pulmonary tumorigenic activity of the tobacco specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) [Abstract]
TOXI 69. 2:00 PM. Stone, Michael. Structure of a stable interstrand DNA crosslink involving a β-N-Glycosyl linkage between an N6-dA amino group and abasic (AP) site [Abstract]
TOXI 70. 2:20 PM. Scharer, Orlando. Replicative and translesion synthesis DNA polymerases in ICL repair [Abstract]
TOXI 71. 2:40 PM. Geacintov, Nicholas. Impact of molecular structure and DNA adduct conformation on the repair and helicase-driven DNA unwinding step in human cell-free assays [Abstract]
TOXI 72. 3:20 PM. Suo, Zucai. Identification and investigation of a novel function of the RuvC nuclease of CRISPR/Cas9 [Abstract]
TOXI 73. 3:40 PM. Zhao, Linlin. Mitochondrial DNA degradation: The potential moonlighting function of mitochondrial transcription factor A [Abstract]
TOXI 74. 4:00 PM. Shafirovich, Vladimir. Interplay of nucleotide excision repair and base excision repair pathway in plasmid DNA substrates harboring oxidatively generated guanine lesions [Abstract]
TOXI 75. 4:20 PM. Yan, James. Evaluation of persistent, bioaccumulative, toxic chemicals under the Frank R. Lautenberg chemical safety for the 21st century act [Abstract]
TOXI 76. 4:40 PM. Kim, Sunghwan. Toxicological information in PubChem [Abstract]

Travel Awards to the 258th ACS Meeting in San Franciosco.

Still Time To Apply

Travel awards for students and post-docs will be available for the TOXI Program at the ACS Meeting  in San Diego.  The students and post-docs will receive up to $750 to help pay for their travel expenses to the ACS Meeting.

The student must

  • be presenting a poster or talk at the TOXI program
  • be a TOXI member.  (You can join now.  Download application and follow instructions)

The application should consist of a single pdf file containing:

1.       A nomination letter from the faculty advisor or laboratory director. The letter should explain why Travel Assistance Award funds are needed.

2.       A curriculum vitae for the applicant.

3.       The abstract for the work to be presented by the nominee at the meeting.

Email applications to Program Chair Penny Beuning at P.Beuning@northeastern.edu.

The deadline for applications is June 15, 2020.

Pete Dedon has won the 2020 Founders’ Award.

Pete Dedon  is Underwood-Prescott Professor of Biological Engineering at the Massachusetts Institute of Technology.  He is Lead Principal Investigator, Antimicrobial Resistance IRG, Singapore-MIT Alliance for Research and Technology, and a Member of the MIT Center for Environmental Health Sciences

Biography: Peter Dedon graduated with a B.A. in Chemistry from St. Olaf College in 1979, and  an M.D. and a Ph.D. in Pharmacology from the University of Rochester in 1987. He pursued postdoctoral research in chromatin biology at the University of Rochester and the chemical biology of DNA-cleaving anticancer drugs at Harvard Medical School. In 1991, Dedon joined the MIT faculty and helped create the Department of Biological Engineering in 1998. As an Underwood Prescott Professor in Biological Engineering, he is currently the Lead PI in the SMART Antimicrobial Resistance group and a member of the MIT Center for Environmental Health Sciences.

Research in the Dedon Lab focuses on the chemical biology of nucleic acids in three broad areas: epigenetics, epitranscriptomics, and genetic toxicology.

Pete’s lab is using analytical chemical techniques to study the ~20 DNA modifications that comprise the epigenome and the >140 chemical modifications of all forms of RNA (epitranscriptomics).

The Dedon Lab uses comparative genomics, single-molecule real-time sequencing, and mass spectrometry to discover novel DNA modifications, such as phosphorothioate and 7-deazaguanine modifications in bacterial and bacteriophage genomes. Work in bacteriophage points to a tremendous variety of DNA modifications with implications for biotechnology, synthetic biology, and human health and disease. For example, we has lab has found oxidation-sensitive phosphorothioate DNA modifications in 10-20% of the organisms in the human microbiome.

In the realm of the epitranscriptome, they applied systems-level analytics to discover a mechanism of translational modulation of gene expression common to humans, parasites, yeast, bacteria, and viruses. Here, environmental stressors cause a “reprogramming” of dozens of tRNA modifications to facilitate selective translation of codon-biased mRNAs critical to the cell stress response and survival, with families of stress-response genes defined by unique biases in the use of synonymous codons.

The Dedon Lab has had a long-standing interest in chemical etiology of human disease, with a focus on the role of inflammation and endogenous DNA damage as drivers of carcinogenesis and age-related diseases. They developed a variety of analytical tools to interrogate genetic toxicology and endogenous molecular damage, including sensitive chromatography-coupled mass spectrometric methods to quantify dozens of different DNA, RNA and protein damage products.

Learn more about Peter Dedon’s work on his lab website.

The winner of the Chemical Research in Toxicology Young Investigator Award for 2020 is Elijah Peterson of the National Institute of Standards and Technology.
Elijah Peterson will lead a half-day conference session as part of the ACS Division of Chemical Toxicology program at the ACS Fall National Meeting in San Francisco, California.

Elijah graduated from Case Western Reserve University in 2003 with BS and MS degrees in Civil Engineering and a BA in Psychology. He received a PhD at the University of Michigan studying the uptake and elimination behaviors of carbon nanotubes using earthworms and sediment-dwelling oligochaetes. He then received a Fulbright scholarship to do postdoctoral research at the University of Joensuu in Finland where he studied the uptake and elimination of carbon nanotubes and fullerenes in Daphnia magna. Elijah joined NIST as a National Research Council postdoctoral research fellow from 2009-2010 and then became a staff research scientist in 2010.

Developing robust assays will enable understanding the potential risks of nanomaterials through the development of a scientifically rigorous research foundation. This will help enable the safe usage of these products thus promoting human and ecological health and facilitating economic activity through the safe commercialization of products utilizing nanotechnology.

His research involves developing robust standard methods for assessing the potential impacts of nanomaterials to organisms and humans.  He is studying how nanomaterials impact the standard battery of toxicological assays as well as developing new tests.  Thus, a research focus in my team is to identify potential artifacts and design control experiments and other modifications to those assays to minimize artifacts and misunderstandings. In addition, he is studying the use of NIST reference materials (RMs) as positive or negative controls for standard toxicity methods to improve assay reliability and generate reference data.

An example of his research is  the development of standard methods with C. elegans for use with nanomaterials and the application of advanced microscopy techniques to improve the robustness of the assays. The sources of variability for an ISO method for C. elegans growth inhibition are being evaluated through cause & effect analysis and experimentation to identify the most critical sources of variability in the assay. I am also focused on the development of methods to accurately quantify nanomaterial concentrations in environmental matrices and organisms to enable bioaccumulation protocols and provide number-based nanoparticle concentrations.

 

.

Previous winners of the award are:

2012:  Yinsheng Wang

2013:  Dean Naisbitt

2014:  Shana Sturla

2015:  Penny Beuning

2016:  Yimon Aye

2017:  Huiwang Ai

2018:  Simon Chan

2019: Silvia Balbo

Visit the CRT website for more information

ACS Fellows 2020 Class.

Now is the time to nominate members of the Division to become ACS Fellows. These nominations can be made by individuals or by the TOXI Division. Divisional nominations made by the Chair of the Division are limited to no more than 4.

The American Chemical Society Fellow  designation is awarded to a member who has made

  1. exceptional contributions to the science or profession and
  2. has provided excellent volunteer service to the ACS community.

Successful nominations need to document scientific accomplishments and service to ACS. Nominations without documentation of a considerable service component will be declined.  To learn more about the nomination process and for a list of current ACS fellows please visit: ACS Fellows Website

Contact Kent Gates, Chair, Awards Committee Division of Toxicology if you would like the Division to consider a nomination at gatesk@missouri.edu

Contact Thomas Spratt if you would like to add another news item to this page