Division of Chemical Toxicology
The mission of the Division is to improve human health and public welfare by promoting the understanding of chemical mechanisms that govern disease processes and the toxicity of drugs, environmental agents, and endogenous chemicals. This will be accomplished by (1) providing a forum for communicating research in the field of chemical toxicology; (2) encouraging further research into chemical mechanisms of toxicity; (3) providing a rigorous scientific basis for risk assessment; (4) providing continuing education, leadership training, and career development opportunities for our fellow chemists; and (5) sponsoring with other societies and divisions, symposia and other programs of mutual interest.
Division of Chemical Toxicology News
The TOXI Division presents awards to the top presentations and poster for students and post-docs. Congratulations to these young scientists.
Top Oral Presentation.
Madjda Bellamri, Robert J. Turesky University of Minnesota
Mechanism of bioactivation of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human prostate
Graduate student presentations
Stephanie Bamberger, Hope Pan, Ryan Bowen, Chanchal Kumar Malik, Tracy Johnson-Salyard, Carmelo Rizzo, Michael P. Stone. Vanderbilt University
Characterization of the 2,6-diamino-4-hydroxy-N5-(methyl)-formamidopyrimidine DNA lesion
Daniel J. Laverty, Marc M. Greenberg. Johns Hopkins University
Abasic and oxidized abasic lesion bypass by DNA polymerase theta yields one- and two-nucleotide deletions
Post-doc Poster Presentations
Hong Mu, Nicholas E. Geacintov, Yingkai Zhang, Suse Broyde. New York University,
Lesion recognition in nucleotide excision repair: Relationship between the structural properties of adducts and initial binding of XPC to the damaged site
Kun Yang, Marc M. Greenberg. Johns Hopkins University.
Histone protein tails inhibit depurination of N7-methylated deoxyguanosine and form DNA-protein crosslinks with alkylated DNA in nucleosome core particles
QingQing Wang, Liwei Weng, Clementina Mesaros, Ian A. Blair. University of Pennsylvania Absolute quantification of plasma fibulin-3 as a biomarker for asbestos exposure by immunoprecipitation-high resolution mass spectrometry
Graduate Student Poster Presentations
Jessica Murray, Meng Huang, Clementina Mesaros, Volker Arlt, Karam El Bayoumy, Ian A. Blair, Trevor M. Penning. University of Pennsylvania
Nrf2-Keap1 signaling and implications for the metabolic activation of nitroarenes
Shaofei Ji, Orlando Scharer, Natalia Y. Tretyakova. University of Minnesota.
Polymerase bypass of DNA-protein and DNA-peptide cross-links
Orrette R. Wauchope, Michelle M. Mitchener, William N. Beavers, James Galligan, Philip Kingsley, Ha-Na Shim, Thomas Blackwell, Thong Luong, Mark deCaestecker, Joshua P. Fessel, Lawrence J. Marnett. Vanderbilt University.
Mitochondrial M1dG levels linked to oxidative stress and mito
Travel Awards to the 254th ACS Meeting in Washington DC Announced.
The Travel Award Committee headed by Irina Stepanov of the University of Minnesota has selected the Travel Award Recipients. These students and post-docs will receive up to $750 to help pay for their travel expenses to the ACS Meeting.
The three graduate students who will receive the award are:
Arindom Chatterjee from Ashis Basu’s lab at the University of Connecticut
Michelle Mitchener from Larry Marnett’s lab at Vanderbilt
Liwei Zheng from Marc Greenberg’s lab at Johns Hopkins
Three post-docs will receive the award:
Suresh Pujari from Natalia Tretyakova’s lab at the University of Minnesota
Maureen McKeague from Shana Sturla’s lab at ETH Zurich
Nathan Price from Yinsheng Wang’s lab at UC Riverside
Division of Chemical Toxicology 2017 Program
Chemical Research in Toxicology, Young Investigator Symposium
- Yinsheng Wang, Univ of California, Riverside. Targeted quantitative proteomic approaches for interrogating the human kinome
- Kent Gates, Univ of Missouri. Sequence-specific covalent capture for detection of disease-derived nucleic acid sequences
- Jin Zhang, Univ of California, San Diego. Dynamic visualization of signaling molecules in living cells
- Huiwang Ai, Chemical Research in Toxicology, Young Investigator Award Winner, Univ of California, Riverside. Seeing is believing: Fluorescent biosensors for redox signaling and oxidative stress
Founders’ Award Symposium.
- F. Peter Guengerich, Vanderbilt Univ. Biochemical and toxicological applications of mass spectrometry
- Trevor Penning, Univ of Pennsylvania. Human aldo-keto reductases and aryl hydrocarbon activation
- Larry Marnett, Vanderbilt Univ. Chemical biology of DNA damage by α,β-unsaturated aldehydes
- Steve Tannenbaum, MIT. S-Nitrosation is a systems-wide regulatory process
- Ian Blair, Founders’ Award Winner, Univ of Pennsylvania. Systems pharmacology approach to the study of mitochondrial dysfunction
TOXI Young Investigators Symposium. Organizer Thomas Spratt, Presiding, Bin Ma and Ujjal Sarkar
- Lili Guo,, University of Pennsylvania, Effect of statins on HMG-CoA reductase pathway and apolipoprotein A-I production in Friedreich’s ataxia
- Madjda Bellamri,, University of Minnesota Mechanism of bioactivation of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human prostate
- Safnas Farwin Abdul Salam,, University of Cincinnati, Novvel class of hydroxyl radical scavenging antioxidants prevents oxidative DNA damage in fibroblast cells exposed to trivalent arsenic
- Jiabin Wu,, University of California, Riverside, Replicative bypass and mutagenic properties of alkylphosphotriester lesions in Escherichia coli
- Daniel J. Laverty,, Johns Hopkins University Abasic and oxidized abasic lesion bypass by DNA polymerase theta yields one- and two-nucleotide deletions
- Stephanie Bamberger, Vanderbilt University Characterization of the 2,6-diamino-4-hydroxy-N5-(methyl)-formamidopyrimidine DNA lesion
- Timothy A. Coulther,, Northeastern University Engineering a replicative DNA polymerase for specific damage bypass capability
- Yan Su,, Vanderbilt University School of Medicine Mechanism of ribonucleotide incorporation by human DNA polymerase Eta
- Liwei Zheng, Johns Hopkins University Independent generation of 2′-deoxyadenosine-N6-yl radical and its reactivity in DNA
- Matthew Ellis, University of Toledo Investigation into the reactivity of a C5′-uridinyl radical
- Ji Jiang, Univ of California Riverside Arsenite binds to the RING finger domain of FANCL E3 ubiquitin ligase and inhibits DNA interstrand cross-link repair
Biological Targets of Botanical Supplements. Organizer Judy Bolton
- Richard van Breemen, Univ of Illinois, at Chicago, Pharmacokinetic Interactions between Drugs and Licorice Botanical Dietary Supplements Used by Menopausal Women
- Mary F. Paine, Washington State Univ, Intestinal UGTs as targets for pharmacokinetic natural product-drug interactions
- Tom Kensler, Johns Hopkins. KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
- Cynthia Rider, NIEHS, Biological Endpoints versus Chemistry in Determining Sufficient Similarity of Botanical Dietary Supplements
- Judy Bolton, Univ of Illinois, at Chicago, Botanicals modulate estrogen metabolism through multiple targets
Crosslink DNA repair. Organizers, Yinsheng Wang and Orlando Scharer
- Johannes Walter, Harvard Medical School, Mechanisms of replication-coupled repair
- Kent Gates, Univ. of Missouri, Interstrand cross-links derived from abasic sites in duplex DNA
- Yinsheng Wang, Univ. of California, Riverside, Occurrence, Replication and repair of DNA interstrand cross-link lesions in human cells.
- Michael Seidman,NIH/NIA, Baltimore, Lesion proximal FANCD2 is required for replication independent repair of interstrand crosslinks.
- Xiaohua Peng, Univ. of Wisconsin, Milwaukee, Hydrogen Peroxide Activated DNA Cross-Linking Agents and Their Biomedical Application
- Lei Li , MD Anderson, Fanconi Anemia pathway and Constitutive Protection of Replication Stress
Toxicological Considerations in Antibody Drug Conjugate Design and Development, Organizers, Fred Guengerich, Nick Meanwell and Griff Humphries
- Pamela A. Trail, Regeneron, Antibody drug conjugates: design considerations for improving efficacy and safety.
- Donglu Zhang, Genentech, Antibody drug conjugates (ADC) linker immolation and cell killing activity
- Omar Ahmad, Pfizer, Development of next generation calicheamicin antibody drug conjugates (ADCs)
- Peter Senter, Seattle Genetics, Potent antibody-based conjugates for cancer therapy: From early stage research to a clinically approved drug
- Paul B Watkins, Univ of North Carolina, Understanding hepatoxicity: man to mouse to computer
POSTER SESSION TOXI Buisness Meeting Student and Post-doc Awards
General Oral Papers. Organizer Thomas Spratt, Presiding, Grover Miller and Linlin Zhao
- Michael P. Stone, Vanderbilt University Chemistry and biology of N5-alkyl-fapy-dG damage in DNA
- Lisa A. Peterson, Univ of Minnnesota Aldehydes increase the tumorigenic properties of tobacco specific nitrosamines in rodent tumor models
- Vladimir Shafirovich NYU Unwinding kinetics of carcinogenic adducts: Correlation with processing by nucleotide excision repair machinery
- Zucai Suo, Ohio State University Structural insights into the post-chemistry steps of nucleotide incorporation catalyzed by a DNA polymerase
- George-Lucian Moldovan, Pennsylvania State University Central role of PCNA in promoting replication of damaged DNA
- Linlin Zhao, Central Michigan University Lucidin-dervied N2-guanine DNA lesion is not a major contributor to the mutagenicity of lucidin
- Lei Li, Indiana University Spore photoproduct within DNA is a surprisingly poor substrate for its designated repair enzyme: The spore photoproduct lyase
- Antony J. Williams, nvironmental Protection Agency, Real-time prediction of physicochemical and toxicological endpoints using the web-based CompTox Chemistry Dashboard
- M S. Marques, Universidade de Lisboa Reaction of the antiepileptic drug carbamazepine with bionucleophiles: Bioactivation is not required
- Kaushik Mitra, Merck and Co. Programed release of nitric oxide, via oxidative metabolism, in animals and humans from clinical candidate MK-8150
- John H. Lauterbach, Lauterbach Associates Can pipe tobaccos be characterized for regulatory purposes without a puff of pipe smoke?
Advanced mass spectrometric techniques in toxicology. Organizers Silvia Balbo, Peter Villalta
- Jonathan Josephs, ThermoFisher Scientific, Advances in mass spectrometry techniques for metabolism, pharmacology and toxicology
- Peter Nemes, George Washington Univ. Capillary Electrophoresis for Trace-level Detection: Metabolites and Proteins.
- Benedikt Warth, Univ of Vienna, Exposing the Exposome: Utilizing global metabolomics to characterize toxicant exposure and effect.
- Balasubrahmanyam Addepalli, Univ of Cincinnati, Probing stress-induced effects on RNA and posttranscriptional modifications by LC-MS.
- Jingshu Guo, Univ. of Minnesota, Advances in human biomonitoring of heterocyclic aromatic amines by high resolution accurate mass spectrometry
Registration is open for ACS Meeting in Washington DC
254th Meeting of the American Chemical Society
August 20-24, 2017
Theme: Chemistry’s Impact on the Global Economy
Early Registration ends July 10.
Presenters, be sure to visit the Presenter’s Tip Page
Huiwang Ai, of the University of California, Riverside has won the sixth annual Chemical Research in Toxicology -Young Investigators Award. He joins past winners Yinsheng Wang, Dean Naisbitt, Shana Sturla, Penny Beuning, and Yimon Aye.
Huiwang Ai’s research focuses on the engineering of novel molecular probes to peer
into cells and brains to understand their communications. He uses a collection of innovative techniques, such as protein engineering and fluorescence and bioluminescence imaging, to dissect signaling pathways involving redox-active molecules, neuromodulators, and protein post-translational modifications.
Huiwang will receive his award at a symposium during the Division of Chemical Toxicology Program at the American Chemical Society’s National Meeting this August in Washington DC.
Ian A. Blair has won the 2017 Founders’ Award from the Division of Chemical Toxicology of the American Chemical Society. Dr Blair has made outstanding contributions to the field of Chemical Toxicology. He has pioneered the use of mass spectrometry to identify biomarkers for carcinogenesis, cardiovascular disease, and neurodegeneration. He developed electron capture atmospheric pressure chemical ionization, which makes it possible to conduct quantitative analyses on chiral biomolecules. See his current research interests on his lab website. Also read an interview from Francesca Lake in Future Science OA.
Dr Blair will receive the Award, during a Symposium, in his honor, in August at the American Chemicals Society’s National Meeting