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Division of Chemical Toxicology

The mission of the Division is to improve human health and public welfare by promoting the understanding of chemical mechanisms that govern disease processes and the toxicity of drugs, environmental agents, and endogenous chemicals. This will be accomplished by (1) providing a forum for communicating research in the field of chemical toxicology; (2) encouraging further research into chemical mechanisms of toxicity; (3) providing a rigorous scientific basis for risk assessment; (4) providing continuing education, leadership training, and career development opportunities for our fellow chemists; and (5) sponsoring with other societies and divisions, symposia and other programs of mutual interest.

Division of Chemical Toxicology News

Division of Chemical Toxicology Elections

The Nominations Committee has put together a very strong slate of candidates for our Fall election for Chair-Elect,  Executive Committee Member-At-Large, and Nominations Committee Member.  Your involvement in all aspects of the Division is crucial for our success; therefore I encourage you to vote in this election.  The election will open starting Thursday, Oct. 25th and close at Midnight (EST) Wednesday, Nov. 7th.

To vote, go to TOXI Elections. Use your email address as your username and your ACS ID number as your password.

If the above link does not work, paste the following URL into your web browser:  http://acschemtox.org/vote2018/

If you have problems voting, contact Candy Chen at HJChen@chehjc@ccu.edu.tw.

Slate of Candidates

Chair Elect

The Chair-Elect is responsible for aiding the Chair in running the Division.  The term is two years, after which the candidate becomses Cahir for two year

Natalia Tretyakova, Ph.D., University of Minnesota

Zucai Suo, Ph.D., Florida State University

Executive Committee, Member-at-Large

Members-at-large of the Executive Committee are elected for 3-year terms.  The duties of the members-at-large are to assist the chair in running the Division.

Linlin Zhao, Ph.D., Central Michigan University

Matilde Marques, Ph.D.,  Instituto Superior Técnico (IST), University of Lisbon, Portugal

Robert Turesky, PhD., University of Minnesota

Nominations Committee Member

The nominations committee is responsible for selecting individuals to run for the elected members of the TOXI Executive Committee.  The term is for three years.

Kent Gates, Ph.D., University of Missouri

Lawrence Marnett, Ph.D., Vanderbilt University

Chair Elect.

The candidate will serve as Chair-Elect in 2019-2020, Chair in 2021-2022, and Immediate Past-Chair in 2023-2024.

Natalia Tretyakova is currently McKnight Distinguished University Professor and Director of the Epigenetics Consortium  at the University of Minnesota-Twin Cities.  Dr. Tretyakova’s research in chemical toxicology is primarily focused on chemical carcinogenesis, DNA-protein cross-linking, and epigenetic effects of environmental exposures and inflammation. She employs mass spectrometry based methodologies to investigate the mechanisms of epigenetic deregulation and cancer causing mutations associated with environmental exposure and lifestyle factors. Professor Tretyakova has pioneered novel methodologies to detect DNA damage, evaluated the ability of altered DNA bases to induce genetic mutations, and developed DNA based biomarkers of cancer risk. Her work has advanced our understanding of the role of DNA damage in human disease, informing future strategies for improving human health. Dr Tretyakova published 112 peer-reviewed publications and She mentored over 22 Ph.D.s and 15 postdoctoral fellows.  She just finished her term as Treasurer of the ACS Division of Chemical Toxicology.

Zucai Suo received a B.S. (chemistry) in 1986 and an M.S. (physical chemistry) in 1989 from Fudan University in Shanghai, China, and a Ph.D. (biological chemistry) in 1997 from Pennsylvania State University at University Park, PA, under the direction of K. A. Johnson. He was Jane Coffin Childs Memorial Fund Postdoctoral Fellow under the guidance of Christopher T. Walsh at Harvard Medical School, Boston, MA. He then spent 16 months as a senior biochemist at Eli Lilly & Company at Indianapolis, IN, and was in a team which successfully developed an anti-hepatitis C protease drug Telaprevir. After the short stay in industry, he moved to The Ohio State University at Columbus, OH, where he was Professor of Chemistry and Biochemistry for 17 years. Since 2018, he has been Eminent Professor and Dorian & John Blackmon Chair in Biomedical Science at Florida State University College of Medicine. He is currently establishing the Drug Discovery Institute at FSU. He has served as a regular and ad hoc member of both NIH study panels and NSF review panels. In addition, he has been on the Editorial Advisory Boards of four scientific journals including Chemical Research in Toxicology and has served as a guest editor for PNAS. His research interests are in both antiviral and anti-cancer drug discovery, and the enzymology of DNA replication, DNA lesion bypass, DNA damage repair, and gene editing. He has published over 100 research papers and won several research awards including an NSF Career Award in 2005 and the OKeanos-CAPA Senior Investigator Award in 2017. In 2013, he was elected to be a fellow of American Association for the Advancement of Science. For the TOXI Division, he has served as its Secretary and a member of its Program Committee, Communications Committee, and Professional Development Committee. He will serve as Treasurer of TOXI in 2020.

Member-at-Large

The candidate will serve as one of the three Members-at-Large on the executive council for a three-year term.

Matilde Marques was born in Santarém, Portugal. She holds B.S. and Ph.D. degrees in chemical engineering and a Habilitation degree (D.Sc.) in chemistry from Instituto Superior Técnico (IST), University of Lisbon, Portugal. She conducted postdoctoral work in chemical carcinogenesis at the FDA National Center for Toxicological Research, USA, and is currently a full professor at the Department of Chemical Engineering of IST, where she teaches organic and medicinal chemistry. She coordinated the M.S. and Ph.D. Chemistry Programs at IST until December 2016 and is currently vice-chair of IST’s Scientific Council.  Her research focuses on the mechanisms of toxicity induced by environmental (e.g., aromatic amines, acrylamide) and therapeutic (e.g., antiestrogens, anti-HIV drugs) xenobiotics, on the development/validation of analytical methodologies for the detection and quantitation of biomarkers of exposure to toxic agents, with emphasis on MS-based methodologies, and on the design, synthesis, and biological evaluation of potential therapeutic agents.  She is a Member of the American Association for Cancer Research, the American Chemical Society, and the Royal Society of Chemistry. She currently chairs the Division of Medicinal Chemistry of the Portuguese Chemical Society and is Council Member of the European Federation for Medicinal Chemistry (EFMC). She serves on the Editorial Advisory Board for Chemical Research in Toxicology, and has been a Member of multiple working groups for the International Agency for Research on Cancer.

Linlin Zhao is an Assistant Professor in the Department of Chemistry and Biochemistry of Central Michigan University. He received his B.S. degree in Chemistry from Jilin University in China (2005) and Ph.D. degree in Bioanalytical Chemistry from University of Connecticut (2010) under the supervision of Prof. James Rusling and John Schenkman. His thesis research focused on designing a cost-effective and high-throughput analytical platform for detecting DNA damage caused by environmental carcinogens. Between late 2010 and mid 2013, he worked with Prof. F. Peter Guengerich at the Department of Biochemistry at Vanderbilt University School of Medicine as a postdoctoral fellow focusing his research on enzymology of DNA polymerases and their interactions with carcinogen-modified DNA. In Fall 2013, she joined the Department of Chemistry and Biochemistry of Central Michigan University as an Assistant Professor. His independent research has centered on the enzymology of DNA-interacting proteins, in particular those function in DNA replication and repair. He has published six peer-reviewed papers in leading scientific journals in his independent position and 22 papers and one book chapter in total in his career. His research has been supported by extramural grants from National Institutes of Health and Department of Defense. His excellence in research has garnered him the top CMU research honor for young faculty, the 2017 Provost’s Award, given to only two faculty per year. He has been involved in teaching chemistry and biochemistry classes at both undergraduate and graduate levels. He developed two brand-new graduate-level classes, Biochemical Toxicology and Biomolecular Structure and Function, at Central Michigan University, which are both very well received. He has been an active member of ACS TOXI division since he was a graduate student, and has contributed to presiding the session and judging the oral and poster presentations in the past TOXI meetings.

Robert Turesky is a Professor in the Department of Medicinal Chemistry and Director of the Masonic Cancer Center’s Analytical Biochemistry shared resource (2013 – present), a mass spectrometry facility devoted to the cancer and chemoprevention programs at the University of Minnesota. Dr. Turesky received his B.Sc. in biochemistry from the University of Massachusetts, Amherst, and PhD in nutrition and food science from M.I.T. Prior to this position, Dr. Turesky was Group Leader of the Biomarkers Unit, Nestlé Research Center, Lausanne, Switzerland (1986 – 2000); Division Director of Chemistry, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, (2000 – 2004); and Principal Investigator, Wadsworth Center, New York State Department of Health (2004 – 2013).  His research is focused on the biochemical toxicology of dietary and environmental toxicants. He has developed mass spectrometric-based methods to measure biomarkers of these genotoxicants designed to understand the role of chemical exposures in the etiology of human cancers.  Novel technologies and MS-based approaches have been established to identify DNA adducts of carcinogens in formalin fixed paraffin embedded tissues and exfoliated urinary cells, two biospecimens largely underutilized in cancer biomarker research. These bioanalytical approaches are expected to provide important new data on the chemicals that damage the genome and contribute to cancer etiology. He has published more than 200 scientific papers in leading journals and book chapters. He has served as Secretary of the Division of Chemical Toxicology (2001 – 2002) and Member at Large (2013 – 2015). He has been a member of the Editorial Advisory Board of Chemical Research in Toxicology 1996 -2002, 2010 – present).

 

Nominating Committee

The candidate will serve a three year term on the Nominating Committee from 2019-2021.  In 2021, the candidate will serve a chair of the committee

Kent Gates
Kent Gates, ACS Fellow, Class of 2016

Kent S. Gates attended the University of Kansas where he earned a B.S. in Chemistry in 1985.  He took his Ph.D. in Chemistry from Northwestern University in 1990 where he worked with Richard Silverman.  Between 1990-92, he was an NIH postdoctoral fellow at the California Institute of Technology, working in the laboratory of Professor Peter Dervan.  Since 1992 he has been a Professor of Chemistry, with a joint appointment in the Department of Biochemistry, at the University of Missouri in Columbia, MO, where he currently holds the Schlundt Professorship.  He is a fellow of the ACS (2016) and AAAS (2012)  Gates teaches undergraduate and graduate courses in the areas of organic chemistry, medicinal chemistry, and toxicology.  His research group studies the chemical mechanisms by which bioactive small molecules damage DNA.  Their work with anticancer agents including leinamycin, varacin, fasicularin, myxin, azinomycin B, thiarubrin C, and tirapazamine have helped elucidate novel mechanisms of DNA damage, noncovalent DNA recognition, and pathways by which small organic molecules can undergo intracellular bioactivation to release DNA-damaging reactive intermediates.  Recent work has focused on the generation of interstrand DNA cross-links generated by abasic sites in duplex DNA.  Abasic sites are ubiquitous in cellular DNA. Endogenous cross-links derived from abasic sites may contribute to aging, neurodegeneration, and cancer.

Larry Marnett ACS Fellow

Lawrence J. Marnett, Ph.D., is Dean of Basic Sciences of the School of Medicine, University Professor, Mary Geddes Stahlman Professor of Cancer Research, and Professor of Biochemistry, Chemistry, and Pharmacology at Vanderbilt University. Marnett received his Ph.D. in Chemistry from Duke University and did postdoctoral work at the Karolinska Institute and Wayne State University.  He began his academic career at Wayne State University then moved to Vanderbilt in 1989. Marnett’s research program focuses on the role of bioactive lipids in cancer and inflammation.  He is the author of over 500 research publications and 14 patents and has received an American Cancer Society Faculty Research Award, an Outstanding Investigator Award and a MERIT Award from the National Cancer Institute. He is a Fellow of the American Association for the Advancement of Science and a Fellow of the American Chemical Society. He was the first winner of the Founders Award from the Division of Chemical Toxicology and the first winner of the George and Christine Sosnovsky Award for Cancer Research from the American Chemical Society. At Vanderbilt, he was named a Harvey Branscomb Professor and won the Stanley Cohen Prize. He was the Founding Editor-in-Chief of Chemical Research in Toxicology from 1988-2012

ACS Fellows 2018 Class.

Now is the time to nominate members of the Division to become ACS Fellows. These nominations can be made by individuals or by the TOXI Division. Divisional nominations made by the Chair of the Division are limited to no more than 4.

The American Chemical Society Fellow  designation is awarded to a member who has made

  1. exceptional contributions to the science or profession and
  2. has provided excellent volunteer service to the ACS community.

Successful nominations need to document scientific accomplishments and service to ACS. Nominations without documentation of a considerable service component will be declined.  To learn more about the nomination process and for a list of current ACS fellows please visit: ACS Fellows Website

Contact Trevor M. Penning, Chair, Awards Committee Division of Toxicology if you would like the Division to consider a nomination at penning@upenn.edu

DIVISION OF CHEMICAL TOXICOLOGY

Thomas Spratt, Program Chair

SUNDAY MORNING

Translesion DNA Polymerases

Z. Suo, Organizer, Presiding

8:30 Introductory Remarks.

8:35 . Mechanisms to Coordinate Multiple DNA Polymerases for TLS. M.A. Trakselis

9:15 . Explosive mutation accumulation triggered by heterozygous human Pol å proofreading- deficiency is driven by suppression of mismatch repair. Z.F. Purcell

9:55 Intermission.

10:10 . Finding their way: How error-prone polymerases gain access to the bacterial replisome. J.J. Loparo

10:50 . Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA Polymerase. R. Vayas, G. Efthimiopoulos, J. Tokarsky, C. Malik, A.K. Basu, Z. Suo

SUNDAY AFTERNOON

Founders’ Award

Cosponsored by PROF
J. L. Bolton, Organizer, Presiding

1:00 Introductory Remarks.

1:10 . Biological targets of electrophilic furan metabolites. L.A. Peterson

1:50 . Mass spectrometry studies of DNA and protein adducts of reactive electrophiles. N.Y. Tretyakova

2:30 . Electrophilic targeting of Keap1/Nrf2 signalling for disease prevention and treatment. A. Dinkova-Kostova, T. Honda, A.Y. Abramov

3:10 Intermission.

3:25. Chasing Rainbows? Targeted covalent ligand design guided by precision electrophile signaling technologies. Y. Aye

4:05 . Botanicals electrophiles modify multiple targets. J.L. Bolton

Innovations in Chemistry Supporting Strategic Human Health Risk Assessments

Sponsored by AGRO, Cosponsored by CHAS and TOXI

MONDAY MORNING

Student/Post-Doc

E. G. Prestwich, U. Sarkar, Organizers, Presiding

8:00 . Repair and processing of DNA lesions induced by a dynamic electrophile. S. Byrne, K. Yang, S. Rokita

8:20 . Mechanisms of bioactivation of the tobacco carcinogens and 2-amino-9H-pyrido[2,3- b]indole (AáC) and 4-aminobiphenyl (4-ABP) in human bladder.. M. Bellamri, L. Yao, R. Turesky

8:40 . Development of a novel approach for measuring N’-nitrosnornicotine bioactivation in humans by using deuterium-labeled analogs. E. Carlson, A. Goode, V. Gurvich, I. Stepanov, V. Jain, P. Upadhyaya, S.S. Hecht

9:00 . A scheduled LC-SRM method for targeted DNA adductome analysis. Y. Cui, P. Wang, Y. Wang

9:20 Intermission.

9:30 . Significant impact of divalent metal ions on the fidelity, sugar selectivity, and drug incorporation efficiency of human PrimPol. J. Tokarsky, P. Wallenmeyer, K. Phi, Z. Suo

9:50 . Incorporating histone H2A variants facilitates global excision of uracil residues in nucleosomes. C. Li, S. Delaney

10:10. Integrating multi-“omics”- mass spectrometry-based methods to characterize electronic cigarette exposure in humans. R.P. Dator, P.W. Villalta, C.J. Hooyman, L.A. Maertens, S. Balbo

10:30 . The C’5-pseudouridinyl radical. I. Sappy

10:50 Intermission.

11:00 . Transcriptional inhibition and repair mechanism of alkyl phosphotriester DNA adducts in mammalian cells. Y. Tan, J. Wu, Y. Wang

11:20 . Mass spectroscopy-based metabolomics reveals new insights on the biological effects of copper oxide nanoparticles in a human colon carcinoma cell line. N.G. Chavez Soria, D.S. Aga, G. Atilla-Gokcumen

11:40 . A Sensitive Method for Quantitation of Abasic Sites in Isolated and Cellular DNA byElectrospray Ionization Tandem Mass Spectrometry. H. Chen, C.J. Rizzo, R.J. Turesky

MONDAY AFTERNOON

Chemical Toxicology of Nanomaterials

S. Balbo, Organizer, Presiding

1:00 Introductory Remarks.

1:05. The Future of Nanotoxicology Research: Filling Knowledge Gaps to Safeguard Health. A. Elder

1:45.  Investigation of toxicity mechanism of nano-scale lithium battery material NMC to bacterial models. V. Feng

2:25. The size, surface chemistry and reactivity – all matter as toxicity determinants of fibrous nanomaterials. A.A. Shvedova

3:05 Intermission.

3:20. DNA methylation alterations by nanoparticles. L. Godderis

4:00. Nanomaterial Induced Mechanisms: Focus on Nano Cell Interactions. A. Kraegeloh

MONDAY EVENING

Sci-Mix

T. Spratt, Organizer

8:00 – 10:00

Modified 3-deaza-3-alkyl-adenosines as minor groove alkylation mimics in translesion DNA synthesis. L.J. Weselinski, V. Begoyan, G. Kenyon, M. Tanasova

Ultrasensitive high-resolution mass spectrometric analysis of methyl DNA phosphate adducts in human lung. B. Ma, P.W. Villalta, J.B. Hochalter, I. Stepanov, S.S. Hecht

Application of an in silico tool for the risk assessment of an industrial process compliant to ICH M7 guidelines. M. Burns, M. Ott, S.J. Webb

Structural and dynamic impact of single ribonucleotide incorporation on nucleosome structure.I. Fu, D. Smith, S. Broyde

Identification of photo-degradation products of nitroguanidine and toxicological implications. L. Moores, A. Kennedy, K.A. Gust, M.K. Shukla, L.K. Rabalais, D.L. Henderson, S.J. Jones

Efficiency of Initiating Base Excision Repair on Nucleosome Substrates. A. Garlow, S. Delaney

Nanomaterials in marine environment: toxicity to Artemia salina with and without the presence of Phe and Cd2+. J. Lu, X. Lv, Z. Chen, X. Zhu

Initiation of repair of DNA nucleobase lesions in the nucleosome core particle. M.E. Tarantino, S. Delaney

High-resolution/accurate mass DNA adductomics to screen for doxorubicin-induced adducts as biomarkers of therapeutic efficacy. A. Stornetta, K. Walters, R.P. Dator, V. Guidolin, P.W. Villalta, S. Balbo

Molecular level studies of the impact of poly (oxonorbornenes) and their gold nanoparticles conjugates on D. rerio. embryos. J.N. Klutts, A. Laranang, Z. Zheng, J. Saar, K. Lienkamp, R. Brewster, Z. Rosenzweig

Determining the basis of E. coli DinB and human pol kappa DNA damage specificity. H. Stern, T.A. Coulther, J. Winters, C.L. Mills, M.J. Ondrechen, P. Beuning

DNA damage induced by oxidative stress and lipid peroxidation in leukocyte DNA from African-American and Caucasian smokers. C. Ruszczak, B. Ma, J. Jensen, D. Hatsukami, I. Stepanov

Potential DNA oxidation adducts for disease biomarkers. N.C. Wamer, E.A. Carlson, T.A. Dodson, E.G. Prestwich

Investigation of the effect of 2-phenethyl isothiocyanate (PEITC) on the levels of 4-hydroxy-1- (3-pyridyl)-1-butanone-releasing DNA adducts in oral cells of smokers. A. Jain, G. Yakovlev, B. Ma, I. Stepanov

Petrogenic and pyrogenic polycyclic aromatic hydrocarbons in human urine: comparison of their levels between two geographic regions. C. Mesaros, M. Huang, L.C. Hackfeld, R.P. Hodge, I.A. Blair, T.M. Penning

Surface-modified gold nanoparticles and their long-term impact on cellular pathways. P. Falagan Lotsch, E. Grzincic, C.J. Murphy

Independent Synthesis and Fate of DNA Lesions Generated from Oxidative Damage at the C-3 and C-5 Position of Deoxyribonucleotides. M. Bedi, A.C. Bryant-Friedrich

EB-Fapy-dG adducts of 1,3-butadiene: synthesis, structural identification, and detection in human cells. S.S. Pujari, A. Groehler, D. Najjar, N.Y. Tretyakova

Smoking and inflammation mediated epigenetic changes in a mouse model of lung cancer. J. Fernandez, C. Seiler, Q. Han, N.Y. Tretyakova

Inter-individual differences in metabolism of 1,3-butadiene. A. Degner, G. Madugundu, R. Arora, L.A. Peterson, N.Y. Tretyakova

TUESDAY MORNING

Mechanisms of Binding, Transport & Biotransformation of Toxic Metals

Cosponsored by INOR
B. P. Rosen, Organizer, Presiding

8:30 . Control of metal geometries within de novo designed three-stranded coiled coils. T. Pinter, L. Ruckthong, C. Ervin, V.L. Pecoraro

9:15 . ArsI, a C-As lyase for degradation of environmental organoarsenicals. V.S. Nadar, M. Yoshinaga, B.P. Rosen

10:00 . Understanding the Mechanism of Carbon-Metal Bond Cleavage by the Organomercurial Lyase MerB.. H. Wahba, M. Stevenson, D. Wilcox, J.G. Omichinski

10:45 . Interplay of copper transport proteins in the processing of platinum anticancer drugs in the cell. N. Dolgova, C. Yu, O. Dmitriev

TUESDAY AFTERNOON

Chemical Research in Toxicology Young Investigator Award

W. Chan, Organizer, Presiding

1:00 Introductory Remarks.

1:10 . Oxidized polyunsaturated fatty acids: Are they toxic or bioactive?. J. Lee

1:50 . Antibiotics induce nitrosative stress in microorganisms. C.T. Chan

2:30 Intermission.

2:45. Advances in Human Biomonitoring of Carcinogens by Ion Trap and High Resolution Accurate Mass Spectrometry. R. Turesky

3:25. Chemical approaches to investigate the toxicity of aristolochic acids. W. Chan

Keynote Lectures

T. Spratt, Organizer
N. E. Geacintov, Presiding

4:30 Introductory Remarks.

4:40. Linking mutational spectra of chemical carcinogens to the mutational patterns seen in human tumors. J. Essigmann, B.I. Fedeles

TUESDAY EVENING

Posters

T. Spratt, Organizer

7:00 – 9:00

Prediction of carcinogenic behavior of hexacyclic polycyclic aromatic hydrocarbons using aromatic sextet theory and ionization potentials. J.O. Ona Ruales

Toxic Effects and Molecular Mechanism of Silver Nanoparticles to Daphnia magna. J. Hou

Modified 3-deaza-3-alkyl-adenosines as minor groove alkylation mimics in translesion DNA synthesis. L.J. Weselinski, V. Begoyan, G. Kenyon, M. Tanasova

Ultrasensitive high-resolution mass spectrometric analysis of methyl DNA phosphate adducts in human lung. B. Ma, P.W. Villalta, J.B. Hochalter, I. Stepanov, S.S. Hecht

Screening for DNA Adducts in Human Colon by High-Resolution Nano-ESI UHPLC/MSn. D. Konorev, R. Turesky

Application of an in silico tool for the risk assessment of an industrial process compliant to ICH M7 guidelines. M. Burns, M. Ott, S.J. Webb

Methylation in human hemoglobin is associated with age as analyzed by liquid chromatography tandem mass spectrometry. H.C. Chen, S. Ip

Characterizing Uracil DNA Glycosylase Processivity in Nucleosome Core Particles. E. Kennedy, S. Delaney

Structural and dynamic impact of single ribonucleotide incorporation on nucleosome structure. I. Fu, D. Smith, S. Broyde

Identification of photo-degradation products of nitroguanidine and toxicological implications. L. Moores, A. Kennedy, K.A. Gust, M.K. Shukla, L.K. Rabalais, D.L. Henderson, S.J. Jones

Gallic acid derivatives inhibit DNA repair enzyme ALKBH2. Q. Tang, F. Chen, H. Ma, K. Bian, D. Li

Conformation-specific replication block from bulky 4-aminobiphenyl-modified DNA lesions. A. Cai, K. Bian, F. Chen, D. Li, B. Cho

Mutagenicity of DNA-Peptide Crosslink in Human cells. S. Naldiga, S. Ji, G. Moldovan, N.Y. Tretyakova, A.K. Basu

Efficiency of Initiating Base Excision Repair on Nucleosome Substrates. A. Garlow, S. Delaney

Replication studies of N3-methyladenine in Escherichia coli cells. J. Yuan, Y. Wang

Unmasking the role of protein modification in the observed toxicity of aristolochic acid. C. Chan, W. Chan

Adverse reactions induced by the antiepileptic drug oxcarbazepine may stem from its metabolic biotransformation to carbamazepine. I. Martins, C. Charneira, M. Marques, A. Antunes

Identification of 4-(methylnitroamino)-1-(3-pyridyl-1-oxide)-1-butanone, a novel metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rat urine. L. von Weymarn, R. Dator, S. Balbo, S.E. Murphy

Initiation of repair of DNA nucleobase lesions in the nucleosome core particle. M.E. Tarantino, S. Delaney

Dual cell system for in vitro studies of toxic blood gases. W.G. Senanayake, I. Petrikovics, D.E. Thompson

Analysis of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human lung DNA from smokers and nonsmokers. J. Yang, S. Balbo, P.W. Villalta, S.S. Hecht

High-resolution/accurate mass DNA adductomics to screen for doxorubicin-induced adducts as biomarkers of therapeutic efficacy. A. Stornetta, K. Walters, R.P. Dator, V. Guidolin, P.W. Villalta, S. Balbo

Molecular level studies of the impact of poly (oxonorbornenes) and their gold nanoparticles conjugates on D. rerio. embryos. J.N. Klutts, A. Laranang, Z. Zheng, J. Saar, K. Lienkamp, R. Brewster, Z. Rosenzweig

Oxidation and Removal of Cytosine Derivatives in the Nucleosome. P. Caffrey, S. Delaney

Determining the basis of E. coli DinB and human pol kappa DNA damage specificity. H. Stern, T.A. Coulther, J. Winters, C.L. Mills, M.J. Ondrechen, P. Beuning

Prediction of the interaction region between the Y-family polymerase DinB and the transcription-repair coupling factor Mfd in E. coli. S.K. Fields, P. Beuning

Machine learning models for predicting hepatic steatosis based on in vivo data. B. Zdrazil, S. Jain, S. Klinting, S. Escher, G.F. Ecker, U. Norinder

Predicting drug metabolites using bacterial-based models. P.C. Rosado, J.P. Cruz, M.C. Justino, M. Marques, G.C. Justino

pCharacterization of LexA-regulated protein YbfE in E. coli. A. Hotchkiss, C. Kramer, P. Beuning

DNA damage induced by oxidative stress and lipid peroxidation in leukocyte DNA from African-American and Caucasian smokers. C. Ruszczak, B. Ma, J. Jensen, D. Hatsukami, I. Stepanov

p Analysis of the spectrum of DNA modifications in Pseudomonas aeruginosa. E.A. Carlson, N.C. Wamer, T.A. Dodson, E.G. Prestwich

Probing the conformational dynamics of the Beta sliding clamp in Escherichia coli. M.L. Liriano, B. Koleva, P. Beuning

Potential DNA oxidation adducts for disease biomarkers. N.C. Wamer, E.A. Carlson, T.A. Dodson, E.G. Prestwich

Rapid microplate assay for acellular reactive oxygen species generation induced by engineered nanomaterials in real-time. R. Coreas, W. Zhong

Identifying toxicology concepts in the replacement of mercury catalysts during the acetylene hydrochlorination of vinyl chloride monomers. L. Green, J. Marshall, A.S. Cannon

Petrogenic and pyrogenic polycyclic aromatic hydrocarbons in human urine: comparison of their levels between two geographic regions. C. Mesaros, M. Huang, L.C. Hackfeld, R.P. Hodge, I.A. Blair, T.M. Penning

Dissecting interactions between E. coli DNA polymerase III and single-stranded DNA binding protein to gain insights into polymerase management. J. McIsaac, m. ondrechen, P.J. Beuning

Release of lead (Pb) and formation of disinfection byproducts during drinking water disinfection in the water distribution system. J. Liu, V.K. Sharma, C.M. Sayes

Mineralogy dependent dissolution of inhaled uranium in simulated lung fluids in uranium mine lands, New Mexico. E. Hettiarachchi, S. Paul, D. Cadol, B. Frey, G. Rubasinghege

Reactive oxygen species (ROS)-dependent release of an inhibitor from an aptamer. G. Premnauth, E.J. Merino

Effect of surface charge on toxicity of AuNPs; Are cationic AuNPs toxic?. E. Lee, Y. Kwon

Nanomaterials in marine environment: toxicity to Artemia salina with and without the presence of Phe and Cd2+. J. Lu, X. Lv, Z. Chen, X. Zhu

Molecular characterization of alcohol-induced DNA damage for cancer prevention. V. Guidolin, A. Carra’, P.W. Villalta, E. Carlson, S. Balbo

EB-Fapy-dG adducts of 1,3-butadiene: synthesis, structural identification, and detection in human cells. S.S. Pujari, A. Groehler, D. Najjar, N.Y. Tretyakova

Inter-individual differences in metabolism of 1,3-butadiene. A. Degner, G. Madugundu, R. Arora, L.A. Peterson, N.Y. Tretyakova

2, 2’, 3, 5’, 6 polychlorinated biphenyls (PCB-95) induce behavioral and GABAgenic neurotransmitter changes in zebrafish at early developmental exposure. P. Ranasinghe, C.M. Lee

Investigation of the effect of 2-phenethyl isothiocyanate (PEITC) on the levels of 4-hydroxy-1- (3-pyridyl)-1-butanone-releasing DNA adducts in oral cells of smokers. A. Jain, G. Yakovlev, B. Ma, I. Stepanov

Smoking and inflammation mediated epigenetic changes in a mouse model of lung cancer. J. Fernandez, C. Seiler, Q. Han, N.Y. Tretyakova

Independent Synthesis and Fate of DNA Lesions Generated from Oxidative Damage at the C-3’and C-5′ Position of Deoxyribonucleotides. M. Bedi, A.C. Bryant-Friedrich

Ecotoxicology of nano-perovskites in aquatic environment. T. Zhou, W. Fan

Thermodynamic exposure reduction by amendment techniques to limit bioaccumulation during ongoing depositional input – a sediment mesocosm study with three organisms. A.P. Wang

MegaTox for Predicting Compound Liabilities. K.M. Zorn, T. Lane, D.P. Russo, A. Clark, S. Ekins

Information-Derived Adverse Outcome Pathways with a Case Study on Structural Cardiotoxicity. A. Bender

Morphology-dependent cytotoxicity of SiC nanomaterials to human mesenchymal stem cells. F. Chen, G. Li, E. Zhao, J.V. Jokerst

Nanotoxicity predictive modeling: A case study on metal oxides nanoparticles. B. Rasulev

Surface-modified gold nanoparticles and their long-term impact on cellular pathways. P. Falagan Lotsch, E. Grzincic, C.J. Murphy

WEDNESDAY MORNING

Nanomaterials in Drug Delivery: Efficacy & Toxicity Considerations

Cosponsored by MEDI
P. F. Guengerich, W. G. Humphreys, N. A. Meanwell, Organizers, Presiding

8:00Introductory Remarks.

8:05. What exactly is toxic about colloidal nanoparticle formulations? Results from the molecular level and the cellular level. C.J. Murphy

8:45. Targeting or Enhanced Selectivity: Toxicological considerations of nanoparticle therapeutics. R. Darvari

9:25. Expansile nanoparticles for the treatment of intraperitoneal mesothelioma. M.W. Grinstaff

10:05 Intermission.

10:20. Debugging nano–bio interfaces. M. Mahmoudi

11:00. Understanding mast cell activation in the safe development of nanotechnologies. J. Brown

WEDNESDAY AFTERNOON

Topics in Chemical Toxicology

P. Beuning, Organizer
T. Spratt, Organizer, Presiding

1:00. Base and nucleotide excision repair of site-specific oxidatively generated guanine lesions in DNA substrates transfected into human cells. V. Shafirovich, K. Kropachev, M. Kolbanovskiy, N.E. Geacintov

1:20. Reduction pathway-dependent cytotoxicity of reduced graphene oxide. C. Zhang, Q. Zhang

1:40 . Site-Specific Production of Hydroxyl Radicals and Synergistic DNA Damage Induced by the Non-Enzymatic Activation of the Anti-Tuberculosis Drug Isoniazid by Cu(II). B. Zhu

2:00. Insights into the molecular mechanism of alkylation- and platination-induced mutagenesis. S. Lee, Y. Kou

2:20. Kinetic Basis of DNA Synthesis by Human DNA Polymerase/Primase PrimPol. L. Zhao

2:40 Intermission.

3:00. Levels of glyoxal-induced hemoglobin modifications correlate with DNA cross-links in human blood as determined by mass spectrometry. H.C. Chen, C. Liu

3:20. High mobility group box 1: a re-evaluation of its role in cancer. I.A. Blair, L. Weng, L. Guo, A. Vachani, C. Mesaros

3:40. Determining Associations between Transcriptomics and Toxicity using Co-Expression Network Methods. B. Alexander-Dann, T. James, A. Bender

4:00. Inhibitors of the mitochondrial respiratory complex – Structure-based prediction of toxicity. G.F. Ecker, F. Troger, S. Jain, B. Zdrazil

4:20. Configurational and Conformational Equilibria of the N6-(2-Deoxy-D-erythro- pentofuranoysl-)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine (MeFapy- dG) Lesion in DNA. M.P. Stone, S.N. Bamberger, C.K. Malik, T.L. Johnson-Salyard, S.K. Brown, H. Pan, C.J. Rizzo, M.W. Voehler

4:40 . Using open bioactivity data for developing machine-learning prediction models for chemical modulators of the retinoid X receptor (RXR) signaling pathway. S. Kim

Travel Awards to the 256th ACS Meeting in Boston.

Travel awards for students and post-docs will be available for the TOXI Program at the ACS Meeting  in Boston.  The students and post-docs will receive up to $750 to help pay for their travel expenses to the ACS Meeting.

The student must

  • be presenting a poster or talk at the TOXI program
  • be a TOXI member.  (You can join now.  Download application and follow instructions)

 

The application should consist of a single pdf file containing:

1.       A nomination letter from the faculty advisor or laboratory director. The letter should explain why Travel Assistance Award funds are needed.

2.       A curriculum vitae for the applicant.

3.       The abstract for the work to be presented by the nominee at the meeting.

Applications can be submitted to Dr. Thomas Spratt at tes13@psu.edu  by July 1.

The TOXI Division presents awards to the top presentations and poster for students and post-docs.  Congratulations to these young scientists.

Top Oral Presentation.

Madjda Bellamri, Robert J. Turesky University of Minnesota
Mechanism of bioactivation of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human prostate

Graduate student presentations

First Place

Stephanie Bamberger, Hope Pan, Ryan Bowen, Chanchal Kumar Malik, Tracy Johnson-Salyard, Carmelo Rizzo, Michael P. Stone. Vanderbilt University
Characterization of the 2,6-diamino-4-hydroxy-N5-(methyl)-formamidopyrimidine DNA lesion

Second Place

Daniel J. Laverty, Marc M. Greenberg. Johns Hopkins University
Abasic and oxidized abasic lesion bypass by DNA polymerase theta yields one- and two-nucleotide deletions

Post-doc Poster Presentations

First Place

Hong Mu, Nicholas E. Geacintov, Yingkai Zhang, Suse Broyde. New York University,
Lesion recognition in nucleotide excision repair: Relationship between the structural properties of adducts and initial binding of XPC to the damaged site

Scond Place

Kun Yang, Marc M. Greenberg. Johns Hopkins University.
Histone protein tails inhibit depurination of N7-methylated deoxyguanosine and form DNA-protein crosslinks with alkylated DNA in nucleosome core particles

Third Place

QingQing Wang, Liwei Weng, Clementina Mesaros, Ian A. Blair. University of Pennsylvania Absolute quantification of plasma fibulin-3 as a biomarker for asbestos exposure by immunoprecipitation-high resolution mass spectrometry

Graduate Student Poster Presentations

First Place

Jessica Murray, Meng Huang, Clementina Mesaros, Volker Arlt, Karam El Bayoumy, Ian A. Blair, Trevor M. Penning. University of Pennsylvania
Nrf2-Keap1 signaling and implications for the metabolic activation of nitroarenes

Second Place

Shaofei Ji, Orlando Scharer, Natalia Y. Tretyakova. University of Minnesota.
Polymerase bypass of DNA-protein and DNA-peptide cross-links

Third Place

Orrette R. Wauchope, Michelle M. Mitchener, William N. Beavers, James Galligan, Philip Kingsley, Ha-Na Shim, Thomas Blackwell, Thong Luong, Mark deCaestecker, Joshua P. Fessel, Lawrence J. Marnett. Vanderbilt University.
Mitochondrial M1dG levels linked to oxidative stress and mito

Judy Bolton has been named the recipient of the 2018 Founders’ Award.  Judy Bolton is  currently Distinguished Professor and Head, Medicinal Chemistry and Pharmacognosy  at the University of Illinois at Chicago.  Dr Bolton’s research in chemical toxicology is primarily focused on post-menopausal women’s health. She studies the carcinogenic effects of estrogens and antiestrogens and investigates natural alternatives to hormone replacement therapy. She is interested in determining why women who are taking hormone replacement therapy or selective estrogen receptor modulators (SERMs) are at increased risk for developing hormone dependent cancers such as breast or endometrial cancers. By developing a good understanding of the mechanism of how these widely prescribe drugs lead to increased cancer risk, we will be able to design alternatives that maintain the beneficial properties of estrogens/SERMs without generating genotoxic side effects.  Dr Bolton has been active in  educating the next generation of breast cancer researchers and chemical biologists as she has  mentored over 20 Ph.D. and 25 postdoctoral fellows.  Dr Bolton will organize a symposium at the TOXI Division’s program this summer in Boston.

John Essigmann will present the Keynote lecture on Tuesday afternoon, August 21, 2018 during the TOXI program at the American Chemical Society National Convention in Boston.  John  is the William R. (1956) and Betsy P. Leitch Professor in Residence of Chemistry in the MIT Department of Chemistry.   He is also  Professor of Toxicology and Biological Engineering in the MIT Department of Biological Engineering. In addition, he is Director of the MIT Center for Environmental Health Sciences.

John earned a BS in Chemistry at Northeastern University and a PhD from MIT under the direction of Gerald Wogan, a pioneer in the field of chemical toxicology.

The overarching theme in John’s research is to understand how DNA damage leads to cancer and cell death.  In particular, he strives to understand how the chemical and physical properties of specific DNA adducts lead to mutagenesis or cell death.  He then uses this knowledge to design antitumor drugs in a  process described as Fatal Engineering.

John’s lab was the first to synthesize and insert a single DNA adduct at a specific site in DNA in a cell.  This revolutionary process has lead to his lab and, many others, probe the effects of specific DNA adducts to mutagenesis and lethality.  In addition, the DNA damage response to these adducts have been identified.

John’s has used the knowledge gained in his mechanistic studies to design programmable antitumor drugs through a process described as Fatal Engineering.   The Essigmann lab exploits the presence of tumor specific proteins, so that repair of the DNA adduct derived from the drug will occur in normal cells but fail in tumor cells.  Thus the programmable drug kills tumor  but not normal cells.

Simon Chan wins the 2018 Chemical Research in Toxicology Young Investigator Award. Simon Chan is Associate Professor in the Department of Chemistry at the Hong Kong University of Science and Technology. Visit Lab website. Dr Chan will present a lecture on Tuesday afternoon, Aug 21, 2018 during the Division’s Program at the ACS National Meeting in Boston. Simon Chan joins a list of impressive young scientists who have won this award including Yinsheng Wang, Dean Naisbitt, Shana Sturla, Penny Beuning, Yimon Aye, and Huiwang Ai.

Dr Chan’s research focus is on the chemical toxicology of food safety. His most important paper, “Quantitation of Aristolochic Acids in Corn, Wheat Grain, and Soil Samples Collected in Serbia: Identifying a Novel Exposure Pathway in the Etiology of Balkan Endemic Nephropathy,” J Agric. Food Chem., 64:5928-5934. (2016), was named the “Research Article of the Year” in the Journal of Agriculture and Food Chemistry. Through the work of Arthur Grollman and colleagues, we know that aristolochic acids are the cause of Balkan Endemic Neuropathy. It was thought that contamination of wheat and corn with Aristolochia clematitis berries was the route of human exposure to aristolochic acids. However, Simon Chan and co-workers showed that humans can be exposed to aristolochic acids directly through corn and wheat because these plants can absorb aristolochic acids from the soil. This work will impact strategies that we use to decrease exposure to these harmful environmental toxicants.

Contact Thomas Spratt if you would like to add another news item to this page