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Chemical Research in Toxicology
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Chemical Carcinogen Reference Standards Synthesis Program
The National Cancer Institute and Division of Cancer Biology announce the formation of the Chemical Carcinogen Reference Standards Synthesis Program, which can provide difficult-to-obtain chemicals for NIH- and NCI-supported researchers. This program replaces the Chemical Carcinogen Reference Standards Repository that was available through the Midwest Research Institute.

Eligibility: Requests will only be accepted from investigators with current NIH funding. Requested chemicals must be related to research described in the Specific Aims of an NIH grant with current active funding. Requests will not be accepted from investigators funded from other non-NIH sources, or from foreign grantees.

Application Format and Submission: Requests for chemicals may be submitted at any time and should be submitted electronically in MS Word or PDF format. Requests should be no more than two pages in length, including references. The application should contain the following information:
  1. The chemical to be synthesized (from the list of 70 compounds on the table below) and the quantity required. Requested quantities should be limited to that which is appropriate for the work proposed in the funding period of the associated grant.
  2. A description of how the chemical is to be used, and how this use is related to an existing NIH grant. Grants should be identified by Grant Number.
  3. A justification of why the chemical is needed, and why it cannot be obtained from other sources.
    Requests must be countersigned by the requestor's Grants Administrative Official. They should be sent via email to Program Officer Ellen Zaika at zaikae@mail.nih.gov

Review: Requests for chemicals will be reviewed by NCI/DCB Program staff as they are received. Priority will be given in the following order: 1) DCB-funded grantees, 2) NCI-funded grantees, and 3) other NIH IC-funded grantees. Requests will be ranked on the basis of the need of the requested chemical for completion of the Aims of the funded grant, significance of the research utilizing the chemical, and programmatic considerations of the Cancer Etiology Branch, the DCB, and the NCI. Requests will be filled in rank order, based on the availability of funds.

Requestors will be notified by NCI or the contractor when synthesis of the requested chemical is initiated, with an estimate of when the chemical will be shipped. Requests will remain active for three additional review cycles. If requests are not selected for synthesis within that time, they will be discarded and the requestor will need to submit a new application.

Reports: Recipients of the compounds from the DCB Repository are required to acknowledge the support of the Repository whenever publicizing the work resulting from these NCI-supplied compounds in any media by including an acknowledgement statement essentially as follows: "This project was performed in part using compound(s) provided by the NCI operated under contract by The Pennsylvania State University, College of Medicine HHSSN261200900026C."

Within 1 year, applicants receiving compounds should submit a report electronically (to zaikae@mail.nih.gov) indicating how compounds were used and the scientific results obtained. Links to publications resulting from the use of the chemicals provided should be included in the report. Failure to provide a report may result in future requests being denied.



List of Chemicals available from the Chemical Carcinogen Reference Standards Synthesis Program
Chemical PSU # NCI#
1 Benzo[a]pyrene 101 G0074
2 1-Hydroxybenzo[a]pyrene 102 L0100
3 3-Hydroxybenzo[a]pyrene 103 L0075
4 7-Hydroxybenzo[a]pyrene 104 L0105
5 9-Hydroxybenzo[a]pyrene 105 L0106
6 Benzo(a)pyrene-trans-7,8-dihydrodiol(+/-) 106 L0113
7 Benzo(a)pyrene-trans-9,10-dihydrodiol 107 L0114
8 Benzo(a)pyrene-trans-7,8-dihydrodiol (-) 108 O0468
9 Benzo(a)pyrene-trans-7,8-dihydrodiol (+) 109 O0473
10 Benzo(a)pyrene-r-7,t-8,t-9,t-10-tetrahydrotetrol(+/-) 110 L0618
11 Benzo(a)pyrene-r-7,t-8,t-9,c-10-tetrahydrotetrol(+/-) 111 L0619
12 Benzo(a)pyrene-r-7,t-8,c-9,t-10-tetrahydrotetrol(+/-) 112 L0629
13 Benzo(a)pyrene-4,5-dihydroepoxide(+/-) 113 L0115
14 Benzo(a)pyrene-r-7,t-8-dihydrodiol-t-9,10-epoxide(+/-) (anti) 114 L0137
15 Benzo(a)pyrene-r-7,t-8-dihydrodiol-c-9,10-epoxide(+/-) (syn) 115 L0152
16 Benzo(a)pyrene-1,6-dione 116 L0109
17 Benzo(a)pyrene-3,6-dione 117 L0110
18 Benzo(a)pyrene-6,12-dione 118 L0111
19 Benzo(a)pyrene-7,8-dione 119 L0288
20 Benzo(a)pyrene-r-7,t-8,c-9,c-10-tetrahydrotetrol(+/-) 120 L0621
21 Benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide (anti) (+) 121 P0702
22 Benzo(a)pyrene-7,8-dihydroepoxide(+/-) 122 L0622
23 Benzo(a)pyrene-trans-4,5-dihydrodiol(+/-) 123 L0129
24 3-Benzo(a)pyrenyl-B-D-glucopyranosiduronic acid 124 K0343
25 7R,8S,9S-Trihydroxy-10S-(N2-deoxyguanosyl-3'-phosphate)-7,8,9,10-tetrahydrobenzo[a]pyrene 125 AD0884
26 1-Hydroxybenz(a)anthracene 126 L0191
27 3-Hydroxybenz(a)anthracene 127 L0193
28 Benz(a)anthracene-trans-3,4-dihydrodiol 128 L0187
29 Benz(a)anthracene-trans-3,4-dihydrodiol-1,2-epoxide (anti) 129 L0189
30 Benz(a)anthracene-trans-8,9-dihydrodiol-10,11-epoxide (syn) 130 L0155
31 Benz[a]anthracene-trans-8,9-dihydrodiol-10,11-epoxide (anti) 131 L0154
32 7,12-Dimethylbenz(a)anthracene-trans-3,4-dihydrodiol 132 L0751
33 Dibenzo[a,l]pyrene 133 G0479
34 (+/-)-r-11,t-12-Dihydroxy-t-13,14-epoxy-11,12,13,14-tetrahydrodibenzo[a,l]pyrene (anti) 134 L0980
35 Chrysene-trans-1,2-dihydrodiol-3,4-epoxide (anti) 135 L0500
36 Chrysene-trans-1,2-dihydrodiol-3,4-epoxide (syn) 136 L0512
37 3-Hydroxychrysene 137 L0413
38 1-Hydroxychrysene 138 L0460
39 Benzo[c]phenanthrene-3,4-diol-1,2-epoxide 139 L0983
40 1-Hydroxybenzo[c]phenanthrene 140 L1106
41 Benzo[g]chrysene-11,12-diol-13,14-epoxide (anti) 141 M1013
42 1-Pyrenyl-B-D-Glucopyranosiduronic acid 142 K1103
43 1-Hydroxypyrene 143 L0723
44 Dibenz(a,c)anthracene-trans-10,11-dihydrodiol-12,13-epoxide (anti) 144 L0456
45 (+/-)-anti-7,12-Dimethylbenz[a]anthracene-3,4-dihydrodiol-1,2-epoxide 145 L1313
46 (+/-)-syn-7,12-Dimethylbenz[a]anthracene-3,4-dihydrodiol-1,2-epoxide 146 L1312
47 1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydrophenanthrene (anti) 147 L1317
48 5-Methylchrysene 148 M0866
49 5-Methylchrysene-r-1,t-2,3,c-4-tetrahydrotetrol 149 L0870
50 Cyclopenta[c,d]pyrene 150 J0471
51 Dibenzo[a,i]pyrene (Benzo[rst]pentaphene) 151 G0062
52 Benzo(k)fluoranthene-trans-8,9-dihydrodiol-10,11-epoxide (anti) 152 L0746
53 Benzo(b)fluoranthene-trans-9,10-dihydrodiol-11,12-epoxide (anti) 153 L0798
54 N-Nitrosomethylurea (NMU) 201 E0049
55 N-Methylacetoxymethylnitrosamine 202 E0215
56 N-Nitroso-L-proline 203 E0174
57 N-Nitrosonornicotine (NNN) 204 E0151
58 N-Methylbenzylnitrosamine 205 E0089
59 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) 206 E0698
60 N-Nitrosoanabasine 207 E0840
61 N-Nitrosoanatabine 208 E0831
62 4-(N-Methyl-nitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) 209 E1154
63 N-Nitrosoguvacoline 210 E1061
64 N-Acetoxy-2-acetylaminofluorene 301 AM0030
65 Azoxymethane 302 F0044
66 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) 303 D0440
67 Methylazoxy methanol acetate 304 F0040
68 7H-Dibenzo(c,g)carbazole 305 H0258
69 2-Hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-Hydroxy PhIP) 306 L1096
70 Cholanthrene 307 G0502



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