March 2017

    By: Paul Hollenberg
    February 28, 2017

    I am writing this today from a spring-like Ann Arbor in the end of February, where the temperature today is 48°F with bright sun. Last week we had temperatures up into the 70’s. This is our second very unusual winter in a row. I assume this is a combination of El Niño along with global warming. I certainly hope it is primarily the former and not the latter. However, we will see what it is over the next several years. This is my last newsletter to the membership as I have transitioned to the Past Chair of the Division. It is hard for me to believe how quickly the time has flown. Serving as Chair of our Division has been an incredibly rewarding experience. I enjoyed both working with the highly dedicated TOXI officers and also getting to know many members of our Division. The elected officers have made my work as Chair easy and very enjoyable, and I would like to take this opportunity to thank all of the elected officers that I have had the good fortune to work with.

    In this newsletter we welcome Professor Nicholas Geacintov as the new Chair of the Division. I would also like to inform you of the results of the recent TOXI election. Our new Chair-Elect is Shana Sturla, Professor of Toxicology at the ETH Zurich, Swiss Federal Institute of Toxicology. Mike Stone, Professor of Chemistry and Biochemistry at Vanderbilt University, is our Treasurer-Elect. Steve Hecht, Professor at the University of Minnesota, is the newly elected member of the Nominations Committee. Nick Meanwell, Executive Director of the Department of Discovery Chemistry and Molecular Technologies at Bristol-Myers Squibb, is the Member-at-Large of the Executive Committee. Sylvia Balbo, Assistant Professor in the School of Public Health at the University of Minnesota, is the new Counselor, and Grover Miller, Associate Professor of Biochemistry and Molecular Biology at the University of Arkansas, is the Alternate Counselor. My congratulations and thanks to them for their continuing service to our Division. Please welcome these new officers to our Division.

    The 254th ACS National Meeting will take place in Washington, D.C., August 20th-24th with the program theme “Chemistry’s Impact on the Global Economy”. Our Program Chair, Thomas Spratt has been working hard to put together a really exciting program for the TOXI Division. The abstract deadline for the meeting is March 27th, 2017. I am also pleased to announce that Dr. Ian Blair from the University of Pennsylvania will be presenting the Richard N. Loeppky Lecture as the awardee of the Founders Award. He also has a very exciting lineup of speakers for the Founders Award Symposium. The preliminary program for the Fall Meeting in Washington, D.C. is provided later in this newsletter.

    I would like to gratefully acknowledge and thank the benefactors of our Division in 2016:
    • Bristol-Myers Squibb
    • National Institutes of Environmental Health Sciences
    • U.S. Food and Drug Administration
    • ACS Publications Division
    • Chemical Research and Toxicology

    In our last newsletter, we featured the Young Investigators who were awarded funding for travel to the National Meeting. In this newsletter we are recognizing and highlighting the Young Investigators who won the awards for Best Poster and Oral Presentations at our Annual Meeting in Philadelphia. I would recommend that you take the time to read their research summaries in this newsletter. Their impressive contributions to research indicate that our discipline of chemical toxicology will continue to be in strong hands, and that the Division has an exceptionally bright future. I would like to thank the Division members who helped in the organization of the oral sessions, symposia, poster sessions, and awards ceremonies, and those who presented their outstanding science at our National Meeting in Philadelphia.

    I am pleased to report that the State of the Division is strong, and I know that with Nick at the helm we will continue to grow in stature.

    I would like to close by thanking all of the members of all our Toxicology Division for their continuing strong support.
    Regards,


    Paul F. Hollenberg, Ph.D.
    Professor Emeritus of Pharmacology
    The University of Michigan Medical School

    Call for Papers for the Division of Chemical Toxicology

    254th Meeting of the American Chemical Society
    Washington, DC
    August 20-24, 2017

    Theme: Chemistry’s Impact on the Global Economy

    capitol

    We have three events open,abraham-and-his-legacy

    • General Poster Session
    • General Oral Session (15 minute talks)
    • Young Investigators (Students and Post-docs)  Oral Session

    The Deadline to submit to TOXI is  Monday, March 27, 2017.

    Submit at the ACS site : https://callforpapers.acs.org/dc2017/TOXI

    Chemical Research in Toxicology, Young Investigators Symposium

    • Huiwang Ai, University of California, Riverside, Nanosensors of redox levels

    Founders’ Award Symposium

    • Ian Blair, Founders’ Award Winner, University of Pennsylvania
    • Larry Marnett, Vanderbilt University
    • F. Peter Guengerich, Vanderbilt University
    • Trevor Penning, University of Pennsylvania
    • Steve Tannenbaum, MIT

    General Oral Papers

    Young Investigators Symposium

    Biological Targets of Botanical Supplements. Organizer Judy Bolton

    • Richard van Breemen, University of Illinois at Chicago, Pharmacokinetic Interactions between Drugs and Licorice Botanical Dietary Supplements Used by Menopausal Women
    • Mary F. Paine, Washington State University, Intestinal UGTs as targets for pharmacokinetic natural product-drug interactions
    • Tom Kensler, Johns Hopkins. KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
    • Cynthia Rider, NIEHS, Biological Endpoints versus Chemistry in Determining Sufficient Similarity of Botanical Dietary Supplements
    • Judy Bolton, University of Illinois, at Chicago, Botanicals modulate estrogen metabolism through multiple targets

    Toxicological Considerations in Antibody Drug Conjugate Design and Development, Organizers, Fred Guengerich, Nick Meanwell and Griff Humphries

    • Pamela A. Trail, Regeneron, Overview of the area and challenges
    • Christopher J. O’Donnell, Pfizer, Optimization of Tubulysin Antibody-Drug Conjugates: A Case Study in Addressing ADC Metabolism
    • S. Cyrus Khojasteh , Genentech, Linker Immolation and Cell Killing Activity
    • Peter Senter, Seattle Genetics, ADME Considerations for the Development of Antibody-Drug Conjugates
    • Sanjeev Gangwar, Bristol-Myers Squibb, Expanding the Reach of Antibody-Drug Conjugates

    Crosslink DNA repair. Organizers, Yinsheng Wang and Orlando Scharer

    • Johannes Walter, Harvard Medical School, A new mechanism of replication-coupled ICL repair
    • Kent Gates, University of Missouri, Interstrand cross-links derived from abasic sites in duplex DNA
    • Lei Li, MD Anderson, Fanconi Anemia pathway and Constitutive Protection of Replication Stress
    • Xiaohua Peng, University of Wisconsin, Milwaukee, Hydrogen Peroxide Activated DNA Cross-Linking Agents and Their Biomedical Application
    • Michael Seidman, NIH/NIA, Baltimore, Lesion proximal FANCD2 participates in replication independent repair of DNA interstrand crosslinks
    • Yinsheng Wang, University of California, Riverside, Occurrence, Repair and Biological Consequences of Psoralen- and Abasic Site-derived Interstrand Crosslink Lesions

    Mass Spectrometry applications in RNA toxicology. Organizer Silvia Balboa

    • Hans Maurer, Saarland University, Overview on newly developed mass spectrometry methodologies and approaches in toxicology
    • Limbach Patrick, Department of Chemistry, University of Cincinnati, Chemical modification of RNA for function analysis
    • Benedikt Warth, University of Vienna, Novel approaches in targeted metabolomics for the investigation of food toxicants
    • Claire Russell, Kings College London, New approach for tissue and fluid proteomics with Tandem Mass Tags to identify low abundant protein biomarkers of disease
    • Silvia Balbo, University of Minnesota, Characterization of DNA damage and the investigation of genotoxicity

     

    Results of the TOXI Elections

    Chair ElectShana Sturla, Professor, ETH Zurich, Swiss Federal Institute of Technology

    Treasurer ElectMichael P. Stone, Professor of Chemistry and Biochemistry, Vanderbilt University

    Nominations Committee MemberStephen S. Hecht, Wallin Land Grand Professor of Cancer Prevention, University of Minnesota

    Executive Committee Member-at-LargeNicholas A. Meanwell, Executive Director, Department of Discovery Chemistry and Molecular Technologies, Bristol-Myers Squibb

    CounselorSilvia Balbo, Assistant Professor, School of Public Health, University of Minnesota

    Alternate CouncilorGrover P Miller, Associate Professor, University of Arkansas for Medical Sciences

    Biosketches

    Shana SturlaShana Sturla received a B.S. (Chemistry) in 1996 from the University of California at Berkeley, and a Ph.D. (Organic Chemistry) in 2001 from the Massachusetts Institute of Technology, where she worked under the direction of Stephen Buchwald.  Under the guidance of Stephen Hecht, she was a postdoctoral fellow of the National Cancer Institute and of the American Chemical Society at the University of Minnesota Cancer Center, and in 2004 became an Assistant Professor at the University of Minnesota.  Her work there was recognized with an NIH Career Development Award and, as a Dominican American, she received an American Association for Cancer Research Minority Scholar in Cancer Research Award.  In 2009, she joined the faculty of the ETH Zurich, the Swiss Federal Institute of Technology, as Associate Professor with tenure and received a European Research Council Grant, a prestigious award supporting frontier research in all disciplines.  She received the 2014 Young Investigator Award for Chemical Research in Toxicology, and in 2015 was promoted to Full Professor of Toxicology at the ETH, and became Vice President of the Swiss Society of Toxicology. The main goal of her research is to understand the chemical basis of mutagenesis and toxicity.  Her lab delineates relationships between chemical structures, enzyme-catalyzed chemical transformations, and cellular responses to environmental and dietary toxicants and cancer drugs.  She has served the TOXI division in various ways from organizing sessions to member-at-large to serving as the program chair in 2011 and 2012; She is a member of the Chemical Research in Toxicology editorial advisory board and has been a guest editor for Systems Toxicology issues.

    Michael P. Stone.  Born August 23,1955, Berkeley, CA.  B.S. Biochemistry, University of California, Davis, 1977; Ph.D, Chemistry, University of California, Irvine, 1981; post-doctoral, Department of Chemistry, The University of Rochester, 1981-84; Faculty, Vanderbilt University, 1984-present, currently Professor of Chemistry and of Biochemistry.  Prof. Stone’s research expertise is in the chemistry and structural biology of DNA damage, including DNA cross-linking, and involving human exposures to aflatoxins, α,β-unsaturated aldehydes, styrene and butadiene, aryl amines, and polycyclic aromatic hydrocarbons. The Stone lab utilizes both NMR spectroscopy and crystallography for structural determinations.  Prof. Stone has published 130+ peer-reviewed publications.  At Vanderbilt University, Prof. Stone has taught general chemistry, analytical chemistry, and physical chemistry. He directs the Structural Biology Core Facility of an NIEHS P30 Center in Molecular Toxicology. Prof. Stone serves on the Editorial Board of Chemical Research in Toxicology.  He is a Fellow of the American Association for the Advancement of Science and a member of the American Chemical Society, The Biophysical Society, and Sigma Xi.

    Stephen HechtStephen S Hecht, PhD is an internationally recognized expert on carcinogens in tobacco products and their mechanisms of action.  He is the co-discoverer of tobacco-specific nitrosamines, important causative agents for tobacco-induced cancer.  His laboratory developed the NNAL biomarker of tobacco carcinogen exposure, crucial in establishing secondhand smoke as a lung carcinogen in non-smokers. His current research focuses on the relationship of human carcinogen and toxicant metabolites and DNA adducts to cancer risk.

    He has a B.S.in chemistry (Duke University) and a Ph.D. in organic chemistry (MIT).  Prior to moving to the University of Minnesota in 1996, he conducted research at the American Health Foundation in Valhalla, NY, where he was Director of Research from 1987-1996.

    He received the AACR Award for Excellence in Cancer Prevention Research in 2006, and the Founders Award from the Division of Chemical Toxicology, American Chemical Society in 2009.  He was elected an American Chemical Society Fellow in 2009, a Fellow of the American Association for the Advancement of Science in 2014, and selected as the Editor-in-Chief of Chemical Research in Toxicology in 2012.  He has been the recipient of a Merit Award and an Outstanding Investigator Grant from the National Cancer Institute, and an American Cancer Society Research Professorship. He has published over 800 papers in the scientific literature.

    Nicholas MeanwellNicholas A. Meanwell received his B.Sc. (1976) and Ph.D. (1979) degrees from the University of Sheffield, England and conducted post-doctoral studies at Wayne State University, Detroit, Michigan.  In 1982, he joined Bristol-Myers Squbb Research and Development where he is currently an Executive Director in the Department of Discovery Chemistry and Molecular Technologies.  He has led drug discovery programs in the cardiovascular, neurosciences and virology therapeutic areas, work that has resulted in the advancement of 30 clinical candidates that includes temsavir/fostemsavir for the treatment of HIV-1 infection, the HCV NS5A inhibitor daclatasvir, marketed as DaklinzaTM, and the HCV NS3 protease inhibitor asunaprevir, marketed as SunvepraTM.  He is the author/co-author of 210 publications, review articles and book chapters and more than 180 meeting abstracts and is named as an inventor/co-inventor of 118 issued U.S. Patents.  He has presented over 100 invited lectures at National and International meetings, Universities and Schools on Medicinal Chemistry and has organized/co-organized/presided over 30 sessions at National and International Meetings, ACS Webinars in Drug Discovery, ACS Prospectives Meetings and Short Courses.

    He was admitted as a member of the Connecticut Academy of Science and Engineering in February, 2014, was the co-recipient of a PhRMA Research and Hope Award for Biopharmaceutical Industry Research, 2014 for outstanding research in the area of HIV/AIDS, the recipient of the 2015 Philip S. Portoghese Medicinal Chemistry Lectureship Award administered jointly by the ACS Division of Medicinal Chemistry and the Journal of Medicinal Chemistry and he was inducted into the ACS Division of Medicinal Chemistry Hall of Fame on August 18th, 2015.

    Silvia BalboaSilvia Balbo got her M.S. and Ph.D. in Medicinal Chemistry at the University of Torino (Italy) in 2006, doing part of her doctoral thesis work at the Vrije Universiteit Brussel (Belgium). She then joined IARC in Lyon (France) as a post-doctoral fellow under the supervision of Dr Paolo Boffetta. In 2008, Silvia moved to Minneapolis (MN) to join as a post-doctoral fellow the lab of Dr Stephen Hecht. Silvia is now an Assistant Professor of the School of Public Health at the University of Minnesota. She is part of the Division of Environmental Health Science and member of the Masonic Cancer Center. Her work focuses on studying mechanisms of chemical carcinogenesis, in particular those related to alcohol and tobacco exposures. She is developing accurate methods to quantify the genotoxic effects deriving from these exposures and to measure the corresponding DNA damage. She is drawing upon her expertise in organic synthesis, analytical chemistry, cell culture, and molecular epidemiology to develop integrated approaches aiming at characterizing DNA damage samples collected in clinical trials and molecular epidemiology studies.

    Grover MillerGrover P Miller, PhD. earned Chemistry and Biochemistry BS degrees from Louisiana State University (1992) and a PhD under Dr. Stephen J. Benkovic from Penn State University (1997). He pursued postdoctoral research under Dr. F. Peter Guengerich at Vanderbilt University and earned an NIH NRSA Award. In 2001, he joined the University of Arkansas for Medical Sciences and rose to Associate Professor in Biochemistry and Molecular Biology (2007). He teaches medical, graduate, and undergraduate students about protein chemistry, enzymology, xenobiotic metabolism, and scientific communication. His research spans experimental and computational approaches to assess metabolic activation and detoxification of drugs, pollutants, and dietary compounds from the perspective of a chemist. He has delivered 25 invited lectures, published 42 journal articles, and authored 2 US patents. He serves on three editorial boards, including World J Method, Drug Metabolism & Disposition, and Drug Metabolism Reviews.  He served on 17 study sections, including those for the American Heart Association, Czech Science Foundation, Austrian Science Fund, Louisiana EPSCoR, Translational Research Institute Pilot Fund (UAMS), Enhancement Grant for Research Program (Sam Houston State University), Universidad de Puerto Rico-Río Piedras Institutional Research Fund, and the National Science Foundation (NSF), as well as chairing 4 study sections for the American Heart Association.  He also chaired sessions at Regional (2008) and National (2014) ACS meetings. Locally, he served as ACS Section Secretary (2011-2), Chair-Elect (2013), and Chair (2014-5) as well as Chair of Program (2013-4), Recruitment (2013-5), and Revision of Bylaws Committees (2011-2). In recognition of his efforts, he received 2 Outstanding ACS Service Awards (2011-2012).

    Biliyana Kovela

    (1st Place Poster Presentation Awardee)
    Featured in November 2016 Newsletter

    Isabelle Lee

    (2nd place Poster Presentation Awardee)
    I am a doctoral candidate in Pharmacology and trainee in Environmental Health Sciences at the University of Pennsylvania, working under the mentorship of Dr. Trevor Penning. I received my B.S. in Biochemistry at Virginia Tech in 2012. Presently, I am investigating how estrogen receptor-mediated shuttling of genotoxic polycyclic aromatic hydrocarbon (PAH) ortho-quinones into the nucleus may promote lung cancer. Elucidating this mechanism is important, especially in explaining why women are more susceptible to non-smoking-related lung cancers than their male counterparts.

    I am thankful for the training grant, Translational Research Training Program in Environmental Health Sciences (funded by the National Institute of Environmental Health Sciences (NIEHS)), and Dr. Penning for affording me the opportunity to attend the 252nd American Chemical Society National Meeting. I not only had the privilege to listen to the latest scientific findings from some of the best minds in the world, but also had an opportunity to present my work and receive invaluable feedback that will help move my project forward. My poster presentation to the Division of Chemical Toxicology was titled “Estrogen receptor – mediated shuttling of genotoxic PAH ortho-quinones into the nucleus in lung cancer,” and I am enormously grateful and delighted for having been awarded second place for this presentation among graduate students.

    Given the great experience I had in learning, networking and sharing my own scientific findings, I look forward to attending the next ACS National meeting; I especially can’t wait to see what the TOXI Division has in store for us.

    Jennifer Chen

    (3rd Place Poster Presentation Awardee)
    I am currently a doctoral candidate in the laboratory of Dr. Jun Xi in the Department of Chemistry at Drexel University in Philadelphia, PA.

    In the Xi laboratory, we are focused on applying innovative sensing based technologies to investigate the properties of biological systems that are relevant to fundamental biology and future medical applications. The quartz crystal microbalance with dissipation monitoring (QCM-D) is an ultrasensitive mechanical sensing device that is capable of providing real-time, non-invasive measurements of the changes in frequency and energy dissipation of adhered cells. Such measurement has allowed us to quantitatively track the real time change in cell adhesion, which can be used as a platform to screen environmental toxins, evaluate potential drug candidates, and examine cell signaling network. My current research efforts involve understanding of the role of the GPCR signaling network in mediating cell adhesion that plays an essential role in tissue repair and regeneration, cellular regulation, and disease progression.

    I am very grateful for the Division of Chemical Toxicology for giving me the opportunity to present my poster titled “Dissipation Monitoring of the QCM-D to Study Ligand-Induced Cell Signaling” at the 252nd American Chemical Society Meeting in Philadelphia. This exciting experience has allowed me to learn from other professionals in the field, receive constructive feedback on my research, and expand my professional network. I am also sincerely thankful to the officers of the Toxicology Division for awarding me the 3rd place poster award, and I look forward to attending future ACS meetings.

    Byeong Hwa Yui

    (1st Place Postdoctoral Poster Presentation Awardee)
    I am a research associate and a lab manager in the laboratory of Dr. Robert Turesky, housed in the Masonic Cancer Center at University of Minnesota (Twin Cities). I received my PhD in Chemistry from New York University under the supervision of Prof. Nicholas E. Geacintov. My doctoral research interests were focused on the mechanisms of oxidative DNA damage by photo-irradiation and developing liquid chromatography-mass spectrometry techniques to measure the oxidative DNA adducts formed by carcinogens and reactive oxygen species.

    My current research involves the biomonitoring of DNA adducts of carcinogens in human cohorts. I have developed a long sought mass spectrometry method to measure DNA adducts in formalin-fixed paraffin-embedded (FFPE) tissues, a largely underutilized biospecimen for DNA adduct biomarker research. Our methodology was successfully applied to measure DNA adducts of multiple classes of carcinogens, including aristolochic acid, aromatic amines, heterocyclic aromatic amines, polycyclic aromatic hydrocarbons, and N-nitroso compounds. However, the isolation of DNA from FFPE tissues is a major bottleneck in the analysis of DNA adducts. Recently, our group developed a rapid throughput method to isolate DNA from FFPE tissues that increases the sample processing rate by 8-fold over manual methods at a similar cost of consumable reagents and comparable quality of DNA. Our rapid throughput DNA isolation method can be implemented in large scale studies designed to assess the role of exposures to hazardous chemicals and their DNA adducts in the etiology of cancer.

    I am very grateful to the Division of Chemical Toxicology of the ACS for their recognition of our work and awarding me the best poster award at 252th ACS National Meeting. It is my great honor to communicate and build networks with members of TOXI Division. I am looking forward to participating in future ACS meetings.

    Jing Yang

    (2nd Place Postdoctoral Poster Presentation Awardee)
    I received my Ph.D. degree in Analytical Chemistry from the Department of Chemistry at the University of Minnesota. Currently, I am a research associate in the laboratory of Dr. Stephen Hecht at the University of Minnesota. My research in the Hecht lab has been focused on studying the metabolic activation and DNA modification by carcinogens in tobacco products and the human environment. Using mass spectrometry, I am responsible for developing analytical methods for the quantitation of DNA adducts and detoxification urinary metabolites in laboratory animals and humans.

    I had a wonderful experience presenting my recent work on the “analysis of enantiomeric composition of N’-nitrosonornicotine in the urine of cigarette smokers and smokeless tobacco users” in the Division of Chemical Toxicology at the 252nd American Chemical Society National Meeting. It was a great opportunity to receive feedback and exchange ideas with graduate students, postdocs and professors. I was excited to win the 2nd place of the best postdoc poster awards, and I am looking forward to the next ACS meeting.

    Roman Hillebrand

    (3rd Place Postdoctoral Poster Presentation Awardee)
    I am a postdoctoral fellow in Prof. Peter Dedon’s lab in the Bioengineering Department at MIT. I received my Ph.D. in Chemistry at the University of Missouri – Columbia under Prof. Kent S. Gates’ supervision. My dissertation focused on the development of exo-affinity labeling agents for Tyrosine-protein phosphatase non-receptor type 1.

    My current research focuses on mass spectrometry methods for discovering novel DNA and RNA damage products and modifications. These methods combine the sensitivity of multiple reaction monitoring (MRM) with the discovery power of MS scanning to systematically search for unknown 2-deoxynucleoside structures in enzymatic hydrolysates of DNA. Applying this approach to DNA isolated from rats, we found a variety of previously undescribed DNA damage products in different tissues. The structures of these novel 2-deoxyribonucleosides are currently being established. Stepped MRM also revealed age-dependent increases in a previously described adduct, N2-carboxymethyl-dG (CMdG), in liver. CMdG is known to arise from reactions of DNA with glyoxal, the ubiquitous dialdehyde derived from oxidation of glucose, proteins and lipids, and is involved in formation of advanced glycation end-products associated with chronic diseases. This approach thus provides a means to identify the DNA damage products and modifications that truly matter in normal development and tissue-specific pathophysiology of aging.

    ACS meetings are always fun and helpful in broadening your horizons and engaging with other researchers. I am grateful to the officers of the Division for 3rd place in the postdoctoral poster awards.

    Arnold Groehler IV

    (Best Student Oral Presentation Awardee)

    Yun Ding

    (Best Postdoc Oral Presentation Awardee)
    Featured in November 2016 Newsletter

    Social Media and Science

    Social media and science: is it a useful way to advance a career, keep informed, find collaborators, and get yourself known in the world?

    Scientific collaboration occurs most readily if investigators have a connection.  The best way to create these connections is through personal contact, such as at the TOXI Program at the ACS Meeting.  However, with limited resources, it can be difficult to attend these meetings.  We’d like to propose that you can enhance your scientific contacts through social media.

    The TOXI Division has a Twitter account: @acschemtox.  You can check out its feed on our webpage.  If you want to join in the conversation, you can join Twitter network and participate by following these steps:

    1.  Create a Twitter account.
    2.  Follow @acschemtox  –  @acschemtox will follow you back and retweet posts
    3.  Tweet using the hashtags below:

    #acstoxi — Anything related to the Division of Chemical Toxicology

    #toxiinpress — Report your publications.

    #toxidc —  Are you going to the ACS meeting in DC?  Did you like a talk you heard there?  Are you meeting for drinks after the talks?  Let us and everyone following know!  You never know what kind of collaborations you might foster!

    Toxi in Press

    Congratulations to TOXI members who had articles published between October 2016 and February 2017 in Chemical Research in Toxicology

    October 2016
    Menopausal Hormone Therapy, Age, and Chronic Diseases: Perspectives on Statistical Trends
    Judy L. Bolton. Chem Res Toxicol. 2016, 29: 1583-1590. DOI: 10.1021/acs.chemrestox.6b00272

    Human Microdosing with Carcinogenic Polycyclic Aromatic Hydrocarbons: In Vivo Pharmacokinetics of Dibenzo[def,p]chrysene and Metabolites by UPLC Accelerator Mass Spectrometry
    Erin P. Madeen, Ted J. Ognibene, Richard A. Corley, Tammie J. McQuistan, Marilyn C. Henderson, Willam M. Baird, Graham Bench, Ken W. Turteltaub, and David E. Williams. Chem Res Toxicol. 2016, 29: 1641-1650. DOI: 10.1021/acs.chemrestox.6b00169

    Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ
    Jae-Kwon Kim, Mina Yeom, Jin-Kyung Hong, Insil Song, Young-Sam Lee, F. Peter Guengerich, and Jeong-Yun Choi. Chem Res Toxicol. 2016, 29: 1741-1754. DOI: 10.1021/acs.chemrestox.6b00244

    Replicative Bypass of O2-Alkylthymidine Lesions in Vitro
    Nicole L. Williams, Pengcheng Wang, and Yinsheng Wang. Chem Res Toxicol. 2016, 29: 1755-1761. DOI: 10.1021/acs.chemrestox.6b00252

    Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis
    Kimberly Lapham, Jonathan Novak, Lisa D. Marroquin, Rachel Swiss, Shuzhen Qin, Christopher J. Strock, Renato Scialis, Michael D. Aleo, Thomas Schroeter, Heather Eng, A. David Rodrigues, and Amit S. Kalgutkar. Chem Res Toxicol. 2016, 29: 1778-1788. DOI: 10.1021/acs.chemrestox.6b00262

    November 2016
    Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O6-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice
    Sreekanth C. Narayanapillai, Shang-Hsuan Lin, Pablo Leitzman, Pramod Upadhyaya, Carolyn J. Baglole, and Chengguo Xing. Chem Res Toxicol. 2016, 29: 1828-1834. DOI: 10.1021/acs.chemrestox.6b00203

    Diagnostic Microdosing Approach to Study Gemcitabine Resistance
    Tiffany M. Scharadin, Hongyong Zhang, Maike Zimmerman, Sisi Wang, Michael A. Malfatti, George D. Cimino, Kenneth Turteltaub, Ralph de Vere White, Chong-xiang Pan, and Paul T. Henderson. Chem Res Toxicol. 2016, 29: 1843-1848. DOI: 10.1021/acs.chemrestox.6b00247

    Optimized Liquid Chromatography Nanoelectrospray-High Resolution Tandem Mass Spectrometry Method for the Analysis of 4-Hydroxy-1-(3-pyridyl)-1-butanone-Releasing DNA Adducts in Human Oral Cells
    Bin Ma, Chris Ruszczak, Vipin Jain, Samir S. Khariwala, Bruce Lindgren, Dorothy K. Hatsukami, and Irina Stepanov. Chem Res Toxicol. 2016, 29: 1849-1856. DOI: 10.1021/acs.chemrestox.6b00254

    Identification of Protein Thiazolidination as a Novel Molecular Signature for Oxidative Stress and Formaldehyde Exposure
    Jingjing Liu, K.K. Jason Chan, and Wan Chan. Chem Res Toxicol. 2016, 29: 1865-1871. DOI: 10.1021/acs.chemrestox.6b00271

    O6-2’-Deoxyguanosine-butylene-O6-2’-deoxyguanosine DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions
    Wenyan Xu, Daniel Kool, Derek K. O’Flaherty, Ashley M. Keating, Lauralicia Sacre, Martin Egli, Anne Noronha, Christopher J. Wilds, and Linlin Zhao. Chem Res Toxicol. 2016, 29: 1872-1882. DOI: 10.1021/acs.chemrestox.6b00278

    DNA Polymerase v Rapidly Bypasses O6-Methyl-dG but not O6-[4-(3-Pyridyl)-4-oxobutyl]-dG and O2-Alkyl-dTs
    A. S. Prakasha Gowda and Thomas E. Spratt. Chem Res Toxicol. 2016, 29: 1894-1900. DOI: 10.1021/acs.chemrestox.6b00318

    December 2016
    Introduction: Mass Spectrometry and Emerging Technologies for Biomarker Discovery in the Assessment of Human Health and Disease
    Emre M. Isin and Robert J. Turesky. Chem Res Toxicol. 2016, 29: 1901-1902. DOI: 10.1021/acs.chemrestox.6b00429

    Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology
    Hiroshi Yamazaki, Hiroshi Suemizu, Marina Mitsui, Makiko Shimizu, and F. Peter Guengerich. Chem Res Toxicol. 2016, 29: 1903-1911. DOI: 10.1021/acs.chemrestox.6b00136

    Use of Accelerator Mass Spectrometry in Human Health and Molecular Toxicology
    Heather A. Enright, Michael A. Malfatti, Maike Zimmermann, Ted Ognibene, Paul Henderson, and Kenneth W. Turteltaub. Chem Res Toxicol. 2016, 29: 1976-1986. DOI: 10.1021/acs.chemrestox.6b00234

    Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage
    Yang Yu, Yuxiang Cui, Laura J. Niedernhofer, and Yinsheng Wang. Chem Res Toxicol. 2016, 29: 2008-2039. DOI: 10.1021/acs.chemrestox.6b00265

    Drug-Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization
    Jinping Gan, Haiying Zhang, and W. Griffith Humphreys. Chem Res Toxicol. 2016, 29: 2040-2057. DOI: 10.1021/acs.chemrestox.6b00274

    Stability and Application of Reactive Nitrogen and Oxygen Species-Induced Hemoglobin Modifications in Dry Blood Spots As Analyzed by Liquid Chromatography Tandem Mass Spectrometry
    Hauh-Jyun Candy Chen, Chih-Huang Fan, and Ya-Fen Yang, Chem Res Toxicol. 2016, 29: 2157-2163. DOI: 10.1021/acs.chemrestox.6b00334

    Dynamic Phosphorylation of Apoptosis Signal Regulating Kinase 1 (ASK1) in Response to Oxidative and Electrophilic Stress
    Carlos Morales Betanzos, Joel D. Federspiel, Amy M. Palubinsky, BethAnn McLaughlin, and Daniel C. Liebler. Chem Res Toxicol. 2016, 29: 2175-2183. DOI: 10.1021/acs.chemrestox.6b00339

    Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines
    Erik S. Carlson, Pramod Upadhyaya, and Stephen S. Hecht. Chem Res Toxicol. 2016, 29: 2194-2205. DOI: 10.1021/acs.chemrestox.6b00384

    January 2017
    A Special Issue of CRT: Celebrating Volume 30
    Stephen S. Hecht. Chem Res Toxicol. 2017, 30: 1. DOI: 10.1021/acs.chemrestox.6b00440

    Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions
    F. Peter Guengerich. Chem Res Toxicol. 2017, 30: 2-12. DOI: 10.1021/acs.chemrestox.6b00226

    Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects
    Judy L. Bolton and Tareisha Dunlap. Chem Res Toxicol. 2017, 30: 13-37. DOI: 10.1021/acs.chemrestox.6b00256

    Translesion Synthesis of 2’-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases
    Ashis K. Basu, Paritosh Pande, and Arindam Bose. Chem Res Toxicol. 2017, 30: 61-72. DOI: 10.1021/acs.chemrestox.6b00285

    Carcinogenesis of the Oral Cavity: Environmental Causes and Potential Prevention by Black Raspberry
    Karam El-Bayoumy, Kun-Ming Chen, Shang-Min Zhang, Yuan-Wan Sun, Shantu Amin, Gary Stoner, and Joseph B. Guttenplan. Chem Res Toxicol. 2017, 30: 126-144. DOI: 10.1021/acs.chemrestox.6b00306

    Acrolein and Human Disease: Untangling the Knotty Exposure Scenarios Accompanying Several Diverse Disorders
    Philip C. Burcham. Chem Res Toxicol. 2017, 30: 145-161. DOI: 10.1021/acs.chemrestox.6b00310

    Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis
    Trevor M. Penning. Chem Res Toxicol. 2017, 30: 162-176. DOI: 10.1021/acs.chemrestox.6b00319

    Liabilities Associated with the Formation of “Hard” Electrophiles in Reactive Metabolite Trapping Screens
    Amit S. Kalgutkar. Chem Res Toxicol. 2017, 30: 220-238. DOI: 10.1021/acs.chemrestox.6b00332

    Advances in Structural and Single-Molecule Methods for Investigating DNA Lesion Bypass and Repair Polymerases
    Austin T. Raper, Andrew J. Reed, Varun V. Gadkari, and Zucai Suo. Chem Res Toxicol. 2017, 30: 260-269. DOI: 10.1021/acs.chemrestox.6b00342

    Thirdhand Smoke: New Evidence, Challenges, and Future Directions
    Peyton Jacob III, Neal L. Benowitz, Hugo Destaillats, Lara Gundel, Bo Hang, Manuela Martins-Green, Georg E. Matt, Penelope J. E. Quintana, Jonathan M. Samet, Suzaynn F. Schick, Prue Talbot, Noel J. Aquilina, Melbourne F. Hovell, Jian-Hua Mao, and Todd P. Whitehead. Chem Res Toxicol. 2017, 30: 270-294. DOI: 10.1021/acs.chemrestox.6b00343

    Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future
    Gabriele Sabbioni and Robert J. Turesky. Chem Res Toxicol. 2017, 30: 332-366. DOI: 10.1021/acs.chemrestox.6b00366

    Oral Cell DNA Adducts as Potential Biomarkers for Lung Cancer Susceptibility in Cigarette Smokers
    Stephen S. Hecht. Chem Res Toxicol. 2017, 30: 367-375. DOI: 10.1021/acs.chemrestox.6b00372

    Histone Adduction and Its Functional Impact on Epigenetics
    James J. Galligan and Lawrence J. Marnett. Chem Res Toxicol. 2017, 30: 376-387. DOI: 10.1021/acs.chemrestox.6b00379

    DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine
    Alessia Stornetta, Maike Zimmermann, George D. Cimino, Paul T. Henderson, and Shana J. Sturla. Chem Res Toxicol. 2017, 30: 388-409. DOI: 10.1021/acs.chemrestox.6b00380

    Nicotine Metabolism and Smoking: Ethnic Differences in the role of P450 2A6
    Sharon E. Murphy. Chem Res Toxicol. 2017, 30: 410-419. DOI: 10.1021/acs.chemrestox.6b00387

    Context Matters: Contribution of Specific DNA Adducts to the Genotoxic Properties of the Tobacco-Specific Nitrosamine NNK
    Lisa A. Peterson. Chem Res Toxicol. 2017, 30: 420-433. DOI: 10.1021/acs.chemrestox.6b00386

    Chemical Biology of N5-Substituted Formamidopyrimidine DNA Adducts
    Suresh S. Pujari and Natalia Tretyakova. Chem Res Toxicol. 2017, 30: 434-452. DOI: 10.1021/acs.chemrestox.6b00392

    February 2017
    Call for Papers on Mass Spectrometry and Biomarkers in Human Population Studies
    Robert J. Turesky. Chem Res Toxicol. 2017, 30: 487. DOI: 10.1021/acs.chemrestox.6b00431

    Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Linking and Kinase Inhibition
    Jeannie M. Camarillo, Jody C. Ullery, Kristie L. Rose, and Lawrence J. Marnett. Chem Res Toxicol. 2017, 30: 635-641. DOI: 10.1021/acs.chemrestox.6b00374

    Deep Learning to Predict the Formation of Quinone Species in Drug Metabolism
    Tyler B. Hughes and S. Joshua Swamidass. Chem Res Toxicol. 2017, 30: 642-656. DOI: 10.1021/acs.chemrestox.6b00385

    Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (AαC) in Primary Human Hepatocytes
    Medjda Bellamri, Ludovic Le Hegarat, Robert J. Turesky, and Sophie Langouët. Chem Res Toxicol. 2017, 30: 657-668. DOI: 10.1021/acs.chemrestox.6b00394

    Mutagenicity of a Model DNA-Peptide Cross-Link in Human Cells: Role of Translesion Synthesis DNA Polymerases
    Paritosh Pande, Shaofei Ji, Shivam Mukherjee, Orlando D. Schärer, Natalia Y. Tretyakova, and Ashis K. Basu. Chem Res Toxicol. 2017, 30: 669-677. DOI: 10.1021/acs.chemrestox.6b00397

    Isotope Dilution nanoLC/ESI+-HRMS3 Quantitation of Urinary N7-(1-Hydroxy-3-buten-2-yl) Guanine Adducts in Humans and Their Use as Biomarkers of Exposure to 1,3-Butadiene
    Dewakar Sangaraju, Emily J. Boldry, Yesha M. Patel, Vernon Walker, Irina Stepanov, Daniel Stram, Dorothy Hatsukami, and Natalia Tretyakova. Chem Res Toxicol. 2017, 30: 678-688. DOI: 10.1021/acs.chemrestox.6b00407

    DNA Advanced Glycation End Products (DNA-AGEs) Are Elevated in Urine and Tissue in an Animal Model of Type 2 Diabetes
    Richard Jaramillo, Sarah C. Shuck, Yin S. Chan, Xueli Liu, Steven E. Bates, Punnajit P. Lim, Daniel Tamae, Sandrine Lacoste, Timothy R. O’Connor, and John Termini. Chem Res Toxicol. 2017, 30: 689-698. DOI: 10.1021/acs.chemrestox.6b00414

    Mass Spectrometric Characterization of an Acid-Labile Adduct Formed with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Albumin in Humans
    Yi Wang, Peter W. Villalta, Lijuan Peng, Michael A. Malfatti, K.W. Turteltaub, and Robert J. Turesky. Chem Res Toxicol. 2017, 30: 705-714. DOI: 10.1021/acs.chemrestox.6b00426

    Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells
    A. S. Prakasha Gowda, Zucai Suo, and Thomas E. Spratt. Chem Res Toxicol. 2017, 30: 715-725. DOI: 10.1021/acs.chemrestox.6b00451

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