- Message from Chair
- Division of Chemical Toxicology Election
- Fall ACS Meeting Overview
- American Chemical Society Fellows from the TOXI Division, Class of 2016
- TOXI Website Grant Update
- Chair’s Corner
- TOXI In Press
- Student Travel Awards
In this issue:
Message from Chair
by: Paul Hollenberg
October 26, 2016
I’m sure those of you who attended the 252nd National Meeting of the American Chemical Society (ACS) found the meeting to be an extremely exciting and very valuable event. It was a great opportunity to see the incredible research going on in the labs of so many of our colleagues. As usual, the annual program that was presented by our Division of Chemical Toxicology (TOXI) was truly outstanding. Our senior investigators as well as their more junior colleagues, and in particular, postdoctoral fellows and graduate students all presented some truly exciting cutting-edge work. I think we all appreciated hearing of new approaches, techniques and ideas that will certainly stimulate many projects and additional approaches in our own laboratories. I hope that you will read the information about some of the projects that were presented in the next section of this newsletter as part of the Fall Meeting Overview.
The Program Committee led by Dr. Amanda Bryant-Friederich, Associate Professor of Medicinal Chemistry in the College of Pharmacy at the University of Toledo, deserves our high praise for putting together such a truly fantastic program. This is the second year that Amanda has chaired the committee, and she will be stepping down as the Program Chair after a two-year term and will be succeeded by Dr. Thomas Spratt, Associate Professor in the Department of Biochemistry and Molecular Biology at Penn State Hershey. Amanda set a very high bar for next year’s program. However, I am sure that Tom is ready to exceed that goal. Of course, he will need our help in developing outstanding programs over the next two years. I would encourage you as a member of our Division to help Tom by suggesting symposia you would like to see incorporated into our programming and consider helping with coordinating these programs. Please send your suggestions for programming to Tom at firstname.lastname@example.org. Tom is particularly interested in hearing from young investigators regarding symposia that they would like to see as part of our program.
I would also like to give special recognition to Ms. Margaret Martyr at the University of Minnesota for all of her efforts behind the scenes that made sure the Divisional Programming at the meeting ran smoothly. Anyone who has run a scientific meeting or any meeting of this type knows just how much effort it takes to make sure everything is on track, and that all of the required arrangements have not only been made, but also completed in a timely and thorough manner. This includes chasing down missing coffee, microphones, and audio-visual staff as well as making sure malfunctioning equipment is repaired and ready for use by our speakers and attendees. Maggie’s role in supporting the Division Chemical Toxicology has been generously supported by Chemical Research in Toxicology, under Dr. Steven Hecht, the editor of this fine journal.
We were very pleased to hear that Dr. Kent S. Gates, a member of our division, was elected as an ACS Class of 2016 Fellow. The designation as a Fellow is awarded
to those members of the ACS who have distinguished themselves by making exceptional contributions to the science or the profession, and who have provided excellent volunteer service to the ACS community. Dr. Gates uses a variety of different methods, including synthetic organic chemistry, physical organic chemistry, biochemistry, biophysics, and molecular biology to study the molecular mechanisms of drug action. He has made very important scientific contributions over the years by investigating the chemistry and biology of natural products that damage DNA by unusual chemical mechanisms with the ultimate goal of finding new anti-cancer drugs. He is also interested in developing hypoxia-selective anti-tumor agents and in discovering small molecules that can regulate the cellular activity of protein tyrosine phosphatases. In addition to his outstanding research contributions, Kent has made many contributions of service to the Division of Chemical Toxicology over the years. We are very pleased that he was selected as an ACS Fellow.
This time of year brings around our own Division election of new officers. Offices to be filled this year are: Chair-Elect, Treasurer-Elect, Member-At-Large, Counselor/Alternate Counselor, and a Nominations Committee Member. The election of officers for our Division is a very important undertaking. Only by diversifying our leadership structure and identifying truly outstanding leaders can the vitality of our Division be maintained and increased. I strongly encourage you to participate in the electronic balloting for this election. Information on the candidates and the voting procedure will be provided later in this newsletter.
Finally, the Chair’s Corner article in this Newsletter will describe various items discussed at the Annual Business Meeting for those of you who were unable to attend the meeting in Philadelphia.
With my best wishes,
Professor Emeritus of Pharmacology
The University of Michigan Medical School
Shana Sturla received a B.S. (Chemistry) in 1996 from the University of California at Berkeley, and a Ph.D. (Organic Chemistry) in 2001 from the Massachusetts Institute of Technology, where she worked under the direction of Stephen Buchwald. Under the guidance of Stephen Hecht, she was a postdoctoral fellow of the National Cancer Institute and of the American Chemical Society at the University of Minnesota Cancer Center, and in 2004 became an Assistant Professor at the University of Minnesota. Her work there was recognized with an NIH Career Development Award and, as a Dominican American, she received an American Association for Cancer Research Minority Scholar in Cancer Research Award. In 2009, she joined the faculty of the ETH Zurich, the Swiss Federal Institute of Technology, as Associate Professor with tenure and received a European Research Council Grant, a prestigious award supporting frontier research in all disciplines. She received the 2014 Young Investigator Award for Chemical Research in Toxicology, and in 2015 was promoted to Full Professor of Toxicology at the ETH, and became Vice President of the Swiss Society of Toxicology. The main goal of her research is to understand the chemical basis of mutagenesis and toxicity. Her lab delineates relationships between chemical structures, enzyme-catalyzed chemical transformations, and cellular responses to environmental and dietary toxicants and cancer drugs. She has served the TOXI division in various ways from organizing sessions to member-at-large to serving as the program chair in 2011 and 2012; She is a member of the Chemical Research in Toxicology editorial advisory board, has been a guest editor for Systems Toxicology issues.
Ashis Basu received his Ph.D. in Chemistry from Wayne State University, Detroit, MI in1984 and did postdoctoral research at MIT, Cambridge, MA. In 1990 he joined the University of Connecticut where he currently is a Professor of Chemistry. The research focus of the Basu laboratory is determination of the consequences of DNA damaged by anti-tumor drugs, chemical carcinogens, oxidation, or radiation. This research at the interface of Chemistry and Biology involves introduction of specific lesions in DNA by organic synthesis, investigation of the structural effects of the lesions using biophysical methods, and studying their repair and replication. He was a recipient of NIH Research Career Development Award (K02). He has published more than 100 peer-reviewed research articles and received over ten million dollars of extramural grant funds. He has served on many review panels for the American Cancer Society, NIH, and NSF. He was a regular member of the Chemical Pathology and Cancer Etiology study sections of the NIH. He has served as the Treasurer of the Division of Toxicology of the American Chemical Society.
Michael P. Stone. Born August 23,1955, Berkeley, CA. B.S. Biochemistry, University of California, Davis, 1977; Ph.D, Chemistry, University of California, Irvine, 1981; post-doctoral, Department of Chemistry, The University of Rochester, 1981-84; Faculty, Vanderbilt University, 1984-present, currently Professor of Chemistry and of Biochemistry. Prof. Stone’s research expertise is in the chemistry and structural biology of DNA damage, including DNA cross-linking, and involving human exposures to aflatoxins, a,b-unsaturated aldehydes, styrene and butadiene, aryl amines, and polycyclic aromatic hydrocarbons. The Stone lab utilizes both NMR spectroscopy and crystallography for structural determinations. Prof. Stone has published 130+ peer-reviewed publications. At Vanderbilt University, Prof. Stone has taught general chemistry, analytical chemistry, and physical chemistry. He directs the Structural Biology Core Facility of an NIEHS P30 Center in Molecular Toxicology. Prof. Stone serves on the Editorial Board of Chemical Research in Toxicology. He is a Fellow of the American Association for the Advancement of Science and a member of the American Chemical Society, The Biophysical Society, and Sigma Xi.
Judy L. Bolton, Ph.D. I am currently a full professor and Head of the Department of Medicinal Chemistry and Pharmacognosy at the University of Illinois at Chicago. I am an associate editor for Chemical Research in Toxicology and I have served as chair of the Cancer Etiology Study Section, NIH. My research is focused on bioactivation of estrogens and antiestrogens and mechanisms of botanical dietary supplements. I currently have over 150 publications and have already mentored 22 Ph.D. students, 8 masters students, and 27 postdoctoral fellows. Finally, I was recognized with Fellow of the American Chemical Society, 2011.
Stephen S Hecht, PhD is an internationally recognized expert on carcinogens in tobacco
products and their mechanisms of action. He is the co-discoverer of tobacco-specific nitrosamines, important causative agents for tobacco-induced cancer. His laboratory developed the NNAL biomarker of tobacco carcinogen exposure, crucial in establishing secondhand smoke as a lung carcinogen in non-smokers. His current research focuses on the relationship of human carcinogen and toxicant metabolites and DNA adducts to cancer risk.
He has a B.S.in chemistry (Duke University) and a Ph.D. in organic chemistry (MIT). Prior to moving to the University of Minnesota in 1996, he conducted research at the American Health Foundation in Valhalla, NY, where he was Director of Research from 1987-1996.
He received the AACR Award for Excellence in Cancer Prevention Research in 2006, and the Founders Award from the Division of Chemical Toxicology, American Chemical Society in 2009. He was elected an American Chemical Society Fellow in 2009, a Fellow of the American Association for the Advancement of Science in 2014, and selected as the Editor-in-Chief of Chemical Research in Toxicology in 2012. He has been the recipient of a Merit Award and an Outstanding Investigator Grant from the National Cancer Institute, and an American Cancer Society Research Professorship. He has published over 800 papers in the scientific literature.
Executive Committee Member-at-large
Xiaohua Peng is an Associate Professor in the Department of Chemistry and Biochemistry at the University of Wisconsin Milwaukee. She received a B.S. (Chemistry) in 1997 from Nanchang University in Jiangxi, China, an M.S. (Organic Chemistry) in 2000 from Chinese Academy of Sciences, and a Ph.D. in 2006 from the Osnabrueck University in Germany under the supervision of Dr. Frank Seela. She was a recipient of Chinese Government Award for Outstanding Self-financed Students Abroad. After completing her PhD, she joined the Department of Chemistry at the Johns Hopkins University (Baltimore, MD, USA) for postdoc training under the guidance of Dr. Marc M. Greenberg from Nov. 2006 to Jul. 2009. She became an Assistant Professor at the University of Wisconsin Milwaukee (UWM) in 2009 and she is the founding faculty member of UWM’s Milwaukee Institute for Drug Discovery. She has been on the Editorial Advisory Boards of one research journal. She has published over 50 papers in peer-reviewed journals, plus 3 book chapters, 3 invited reviews, and 6 issued patents. She has received several research awards, including the Greater Milwaukee Foundation’s Shaw Scientist Award in 2012, which recognizes the importance, impact, and potential of her contributions to cancer research. She was also a recipient of the Graduate School/UWM Foundation Research Award. Dr. Peng’s lab is currently funded by the National Institutes of Health, Greater Milwaukee Foundation, Bradley foundation, and Wisconsin Applied Research Grant. Her research interest focus on anti-cancer drug discovery, inducible DNA cross-linking agents and their biological and medical applications.
Nicholas A. Meanwell received his B.Sc. (1976) and Ph.D. (1979) degrees from the University of Sheffield, England and conducted post-doctoral studies at Wayne State University, Detroit, Michigan. In 1982, he joined Bristol-Myers Squbb Research and Development where he is currently an Executive Director in the Department of Discovery Chemistry and Molecular Technologies. He has led drug discovery programs in the cardiovascular, neurosciences and virology therapeutic areas, work that has resulted in the advancement of 30 clinical candidates that includes temsavir/fostemsavir for the treatment of HIV-1 infection, the HCV NS5A inhibitor daclatasvir, marketed as DaklinzaTM, and the HCV NS3 protease inhibitor asunaprevir, marketed as SunvepraTM. He is the author/co-author of 210 publications, review articles and book chapters and more than 180 meeting abstracts and is named as an inventor/co-inventor of 118 issued U.S. Patents. He has presented over 100 invited lectures at National and International meetings, Universities and Schools on Medicinal Chemistry and has organized/co-organized/presided of over 30 sessions at National and International Meetings, ACS Webinars in Drug Discovery, ACS Prospectives Meetings and Short Courses.
He was admitted as a member of the Connecticut Academy of Science and Engineering in February, 2014, was the co-recipient of a PhRMA Research and Hope Award for Biopharmaceutical Industry Research, 2014 for outstanding research in the area of HIV/AIDS, the recipient of the 2015 Philip S. Portoghese Medicinal Chemistry Lectureship Award administered jointly by the ACS Division of Medicinal Chemistry and the Journal of Medicinal Chemistry and he was inducted into the ACS Division of Medicinal Chemistry Hall of Fame on August 18th, 2015.
Silvia Balbo got her M.S. and Ph.D. in Medicinal Chemistry at the University of Torino (Italy) in 2006, doing part of her doctoral thesis work at the Vrije Universiteit Brussel (Belgium). She then joined IARC in Lyon (France) as a post-doctoral fellow under the supervision of Dr Paolo Boffetta. In 2008, Silvia moved to Minneapolis (MN) to join as a post-doctoral fellow the lab of Dr Stephen Hecht. Silvia is now an Assistant Professor of the School of Public Health at the University of Minnesota. She is part of the Division of Environmental Health Science and member of the Masonic Cancer Center. Her work focuses on studying mechanisms of chemical carcinogenesis, in particular those related to alcohol and tobacco exposures. She is developing accurate methods to quantify the genotoxic effects deriving from these exposures and to measure the corresponding DNA damage. She is drawing upon her expertise in organic synthesis, analytical chemistry, cell culture and molecular epidemiology to develop integrated approaches aiming at characterizing DNA damage samples collected in clinical trials and molecular epidemiology studies.
Grover P Miller earned Chemistry and Biochemistry BS degrees from Louisiana State Univ (1992) and a PhD under Stephen J. Benkovic from Penn State Univ (1997). He pursued postdoctoral research under F. Peter Guengerich at Vanderbilt Univ and earned an NIH NRSA Award. In 2001, he joined the Univ of Ark for Medical Sciences and rose to Assoc Prof in Biochemistry and Molecular Biology (2007) and Medical Bioinformatics (2016). He teaches medical, graduate, and undergraduate students about protein chemistry, enzymology, xenobiotic metabolism, and scientific communication. His research spans experimental and computational approaches to assess metabolic activation and detoxification of drugs, pollutants, and dietary compounds from the perspective of a chemist. He has delivered 25 invited lectures, published 42 journal articles, and authored 2 US patents. He serves on 3 editorial boards including World J Method, Drug Metab Dispos, and Drug Metab Rev. He served on 17 study sections including those for Amer Heart Assoc, Czech Sci Fdn, Austrian Sci Fund, La EPSCOR, TRI Pilot Fund (UAMS), Enhancement Grant for Res Pgm (Sam Houston State Univ), Universidad de Puerto Rico-Río Piedras Inst Res Fund, and the National Science Foundation (NSF) as well as chairing 4 Study Sections for the Amer Heart Assoc. He also chaired sessions at Regional (2008) and Natl ACS meetings (2014). Locally, he served as ACS Section Secretary (2011-2), Chair-Elect (2013), and Chair (2014-5) as well as Chair of Program (2013-4), Recruitment (2013-5), and Revision of Bylaws Committees (2011-2). In recognition of his efforts, he received 2 Outstanding ACS Service Awards (2011-2012).
Division of Chemical Toxicology Election
The Nominations Committee has put together a very strong slate of candidates for our Fall election for Chair-elect, Treasurer-elect, Member-at-Large, Counselor/Alternate Counselor, and Nominations Committee Member. Your involvement in all aspects of the Division is crucial for our success; therefore I encourage you to vote in this election. The election will open starting Thursday, December 1st and close at Midnight (EST) Thursday, December 15th.
To vote, go to the Election Page. Use your email address as your username and your ACS ID number as your password.
Slate of Candidates
Shana Sturla, ETH
Ashis Basu, University of Connecticut
Michael Stone,Vanderbilt University
Executive Committee Member at Large
Nicholas A. Meanwell, Bristol-Myers Squibb
Xiaohua Peng, University of Wisconsin, Milwaukee
Judy L. Bolton, University of Illinois, Chicago
Stephen Hecht, University of Minnesota
Silvia Balbo, University of Minnesota
Grover Miller, University of Arkansas
See Biosketches in Newsletter
Fall ACS Meeting Overview
By: Paul Hollenberg
November 11, 2016
The 252nd National Meeting of the American Chemical Society was held in Philadelphia during the fourth week of August (August 21-25). Philadelphia was a wonderful city to have the meeting. The meeting venue was excellent and very conducive to scientific discourse, information exchange, developing collaborations, and networking for all of the members of our TOXI Division. Our Division once again presented a truly outstanding program that was organized by Dr. Amanda Bryant-Friedrich. One of the highlights of the meeting was the Chemical Research in Toxicology Young Investigator Symposium organized by Dr. Yimon
Aye, this year’s recipient. The Symposium focused on the generation of reactive electrophiles and reactive oxygen species and the reactions of these reactive intermediates with cellular proteins and DNA leading to post-translational modifications. The post-translational modifications can have effects on the cellular functions of the proteins and DNA, ultimately leading to toxicity. Studies presented also included elucidation of networks connecting the modifications to the cellular change as well as investigations of the chemistry and cellular implications.
Another meeting highlight was the Founders Award Symposium, which was organized by Drs. Suse Broyde and Nicholas Geacintov, this year’s awardees, who presented the Richard N. Loeppky Founders Award Lectures as part of this symposium.
The Symposium topics were concerned with various aspects of DNA damage and repair, including the elucidation of the structural features that affect the recognition and repair of DNA damage.
Our Keynote Lecturer was Dr. Philip C. Hanawalt, who provided a very interesting overview of the developments in the field of DNA damage and repair over the past half-century and provided interesting perspective regarding future developments in the field.
The program also included symposia on: The Fate, Exposure, Remediation, and Adverse Health Effects of Asbestos; Chemical Toxicology and the Study of Health Disparities Among Ethnic/Racial Groups; The Needs and Directions for the Future of Toxicology in Pharmaceutical Development; and DNA Repair and its Role in Defining Human Susceptibility to Disease.
The Young Investigators Symposium on Monday morning featured talks by twelve graduate students and postdoctoral fellows who are rising stars in the field. The General Poster Session held on Tuesday evening featured 49 posters presented by graduate students, postdoctoral fellows, and senior investigators from industry and academia. While the posters were being presented, the participants had plenty of time to visit and discuss the various posters along with an opportunity to enjoy an excellent buffet dinner. A good time was had by all.
Thanks to our program chair and her outstanding committee, the breadth of the programming by our division was truly outstanding and the range of topics covered had a very broad appeal to anyone who might be interested in toxicology. Please mark your calendars for next year’s meeting in Washington, D.C., August 20-24th and plan to attend and submit an abstract. As a reminder, travel awards are available for graduate students and postdocs submitting abstracts. This year the Division was able to provide five travel awards averaging $750 each. Please look for the call for abstracts and applications for travel awards in the Spring Newsletter.
American Chemical Society Fellows TOXI, Class of 2016
November 11, 2016
Kent Gates, Ph.D.
Herman G. Schlundt Professor of Chemistry
Associate Chair for Graduate Studies
University of Missouri
Dr. Gates has distinguished himself in research aimed at elucidating mechanisms by which natural products are biotransformed into DNA damaging agents. These studies have enormous potential in the areas of chemical toxicology and cancer chemotherapy. He has also worked on understanding the chemical mechanisms responsible for DNA-damage by drugs, such as tirapazamine, which are members of a group of hypoxia-selective anti-tumor agents.
Finally, he has made important contributions with respect to discovering small molecules that regulate the cellular activity of protein tyrosine phosphatases. These molecules are of great interest because of their potential to regulate or dis-regulate important signaling pathways. He has served the ACS as a member of the National Awards Canvassing Committee for the Arthur C. Cope Early Career Scholar Award. He served as the Program Chair for the Division of Chemical Toxicology and organized two national meetings for the division during this time. He has also served on a variety of committees for the Division, including the Program, Awards, Nominating, and Fundraising Committees. In addition, he has organized a number of ACS symposia outside of the division of Chemical Toxicology. Congratulations again to Kent for his recognition as an ACS Fellow!
TOXI Website Grant Update
By: Thomas Spratt
November 7, 2016
As you view this Newsletter, you’ll notice our new website is up and running. The two new features are: (1) the site is easily viewable on mobile devices and (2) we have added a Twitter feed to increase communication among members.
The site is now responsive to the size of the screen of the viewing device. You will easily be able to view the site on your smartphone or tablet, as well as desktop. On a desktop, you can see the width of our page and the navigation change as you increase and decrease the width of your browser window. This feature will make viewing the website on your smartphone easier.
Statistically speaking, at least 50% of viewers use a touch-based mobile device such as a smartphone or tablet. That percentage will only increase, making desktop and laptop users a minority when it comes to those visiting any website. We hope to be ahead of the curve in making our site accessible to Chemists.
The second new feature is our Twitter feed, which you can find in the right sidebar. This is from @acschemtox. We have enlisted executive committee members, post-docs and students to contribute. We want to know when our students graduate, where they find positions, and hear about key publications.
Now that I have your attention, add our site to your home screen. See the directions here to add a website to your home screen.
By: Paul Hollenberg
November 11, 2016
The Division of Chemical Toxicology (TOXI) has approximately 1,400 members. Since many of the members were unable to attend our annual meeting, I thought it would be helpful to present some of the highlights of our Business Meeting.
Despite our small size relative to other Divisions in the ACS, “the state of the Division” is very strong. This is due to the fact that we have a nucleus of members in our Division who provide very strong support by giving freely of their time and energy to promote our Division and also to mentor our junior members (postdoctoral fellows and graduate students). The support provided by our members includes serving as officers, serving on Divisional committees, attending and presenting their science at our meetings, and encouraging other scientists interested in various aspects of toxicology, particularly postdoctoral fellows and students, to join our Division and get involved in our activities. If you are not currently involved in the activities of the Division, I would strongly encourage you to become more involved. You find that the active members in our Division are a great group of people and that working as part of the Division will be very helpful to you professionally. It will also be scientifically rewarding and a lot of fun. It will provide you opportunities to meet some great people and provide a network of colleagues in the field of Chemical Toxicology who can help you raise your research to the next level.
Our annual meeting provides unique opportunities for members to become involved. Although our annual meetings are only a small part of a very large national meeting, the culture of the TOXI Division makes it seem like you are part of a small meeting of scientists. By attending, you receive all of the benefits of a small meeting setting, and at the same time you benefit from the advantages of attending a very large national meeting. So, please plan to join us next year.
We have been fortunate over the past several years that our finances, in general, have remained strong in spite of economically challenged times. Until this past year, our revenues approximated our expenses so that we were able to sustain our reserves. However, during the past year we suffered some decreases in revenues as well as increased expenses. Our Finance and Development committee as well as our treasurer are working on ways to turn this around by increasing revenues and decreasing expenses. It should be noted that our income comes primarily from the ACS and is based on the dues from members in the Division, attendance by our members at the national meetings and TOXI Division symposia, and abstract submissions (registration). Therefore, you can significantly help our Division by participating in our meetings, submitting your best science for presentation to our colleagues, and encouraging your colleagues to join our Division and participate in all aspects of the activities of the Division. Our committees and our treasurer will continue to explore other ways to balance our budget and hopefully build our reserves.
During the past year, our Division was very fortunate in that two of our members, Drs. Thomas Spratt and Kaushik Mitra, applied for and were awarded Innovative Program Grants (IPGs) from the ACS. The IPG for Dr. Spratt was to redesign the TOXI website so that it will it be accessible on both desktop and mobile devices. Dr. Spratt has completed the redesign of our website and the details are included earlier in this Newsletter. The IPG awarded to Dr. Mitra was for the purpose of developing a series of webinars covering the various aspects of drug discovery toxicology spanning from in silico toxicity predictions all the way to overall risk assessments. Please look forward to these being rolled out, and we ask that you support them as they are developed.
Our next annual meeting is in Washington, D.C. (August 20-24th, 2017) and the meeting theme is “Chemistry’s Impact on the Global Economy”. This is an area that will be an excellent fit for our Division and we are looking forward to participating in the overall program of the ACS. Dr. Thomas Spratt, our Program Chair is working very hard to put together another truly outstanding Divisional Program.
In closing, I would like to thank all of our members who have participated in the past year
in the activities of our Division. I would also like to encourage all of our members to participate and think about ways that the activities of the TOXI Division can be enhanced. Consider how you can play an important role in doing so. Please contact me with your thoughts and suggestions at (email@example.com). If you are interested in becoming more active in the Division, please do not hesitate to email me to volunteer. Your input and efforts are always welcome, and they can make a big difference for our Division of Chemical Toxicology.
TOXI In Press
Congratulations to TOXI members who had articles published between May and September of 2016 in Chemical Research in Toxicology
Novel Transgenic Mouse Model for Studying Human Serum Albumin as a Biomarker of Carcinogenic Exposure
Jonathan Sheng, Yi Wang, Robert J. Turesky, Kerri Kluetzman, Qing-Yu Zhang, and Xinxin Ding. Chem Res Toxicol. 2016, 29: 797-809. DOI: 10.1021/acs.chemrestox.5b00529
Bioactivation of Heterocyclic Aromatic Amines by UDP Glucuronosyltransferases
Tingting Cai, Lihua Yao, and Robert J. Turesky. Chem Res Toxicol. 2016, 29: 879-891. DOI: 10.1021/acs.chemrestox.6b00046
Comparative Error-Free and Error-Prone Translesion Synthesis of N2-2′-Deoxyguanosine Adducts Formed by Mitomycin C and Its Metabolite, 2,7-Diaminomitosene, in Human Cells
Arindam Bose, Chaitra Surugihalli, Paritosh Pande, Elise Champeil, and Ashis K. Basu. Chem Res Toxicol. 2016, 29: 933-939. DOI: 10.1021/acs.chemrestox.6b00087
Real-Time Cell-Electronic Sensing of Coal Fly Ash Particulate Matter for Toxicity-Based Air Quality Monitoring
Birget Moe, Chungang Yuan, Jinhua Li, Haiying Du, Stephan Gabos, X. Chris Le, and Xing-Fang Li. Chem Res Toxicol. 2016, 29: 972-980. DOI: 10.1021/acs.chemrestox.6b00004
Potential Metabolic Activation of a Representative C2-Alkylated Polycyclic Aromatic Hydrocarbon 6-Ethylchrysene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells
Meng Huang, Clementina Mesaros, Suhong Zhang, Ian A. Blair, and Trevor M. Penning. Chem Res Toxicol. 2016, 29: 991-1002. DOI: 10.1021/acs.chemrestox.6b00036
Structure–Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6
Tsutomu Shimada, Shigeo Takenaka, Kensaku Kakimoto, Norie Murayama, Young-Ran Lim, Donghak Kim, Maryam K. Foroozesh, Hiroshi Yamazaki, F. Peter Guengerich, and Masayuki Komori. Chem Res Toxicol. 2016, 29: 1029-1040. DOI: 10.1021/acs.chemrestox.6b00083
Focus on Fundamental Materials Properties
Joel A. Pedersen and Agnes Kane. Chem Res Toxicol. 2016, 29: 1083-1084. DOI: 10.1021/acs.chemrestox.6b00194
In Chemico Evaluation of Tea Tree Essential Oils as Skin Sensitizers: Impact of the Chemical Composition on Aging and Generation of Reactive Species
Cristina Avonto, Amar G. Chittiboyina, Mei Wang, Yelkaira Vasquez, Diego Rua, and Ikhlas A. Khan. Chem Res Toxicol. 2016, 29: 1108-1117. DOI: 10.1021/acs.chemrestox.5b00530
Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2-Hydroxylation
Shuai Wang, Tareisha L. Dunlap, Caitlin E. Howell, Obinna C. Mbachu, Emily A. Rue, Rasika Phansalkar, Shao-Nong Chen, Guido F. Pauli, Birgit M. Dietz, and Judy L. Bolton. Chem Res Toxicol. 2016, 29: 1142-1150. DOI: 10.1021/acs.chemrestox.6b00112
Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures
Filippo Zanetti, Alain Sewer, Carole Mathis, Anita R. Iskandar, Radina Kostadinova, Walter K. Schlage, Patrice Leroy, Shoaib Majeed, Emmanuel Guedj, Keyur Trivedi, Florian Martin, Ashraf Elamin, Céline Merg, Nikolai V. Ivanov, Stefan Frentzel, Manuel C. Peitsch, and Julia Hoeng. Chem Res Toxicol. 2016, 29: 1252-1269. DOI: 10.1021/acs.chemrestox.6b00174
Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry
Hiroshi Yamazaki, Hiroshi Suemizu, Yasuhiro Kazuki, Ken Oofusa, Shunji Kuribayashi, Makiko Shimizu, Shinichi Ninomiya, Toru Horie, Norio Shibata, and F. Peter Guengerich. Chem Res Toxicol. 2016, 29: 1279-1281. DOI: 10.1021/acs.chemrestox.6b00210
Pyrrolizidine Alkaloid-Protein Adducts: Potential Non-invasive Biomarkers of Pyrrolizidine Alkaloid-Induced Liver Toxicity and Exposure
Qingsu Xia, Yuewei Zhao, Ge Lin, Frederick A. Beland, Lining Cai, and Peter P. Fu. Chem Res Toxicol. 2016, 29: 1282-1292. DOI: 10.1021/acs.chemrestox.6b00120
Chronic Treatment with Isoniazid Causes Protoporphyrin IX Accumulation in Mouse Liver
Madhav Sachar, Feng Li, Ke Liu, Pengcheng Wang, Jie Lu, and Xiaochao Ma. Chem Res Toxicol. 2016, 29: 1293-1297 DOI: 10.1021/acs.chemrestox.6b00121
Polychlorinated Biphenyls Induce Oxidative DNA Adducts in Female Sprague–Dawley Rats
Esra Mutlu, Lina Gao, Leonard B. Collins, Nigel J. Walker, Hadley J. Hartwell, James R. Olson, Wei Sun, Avram Gold, Louise M. Ball, and James A Swenberg. Chem Res Toxicol. 2016, 29: 1335-1344. DOI: 10.1021/acs.chemrestox.6b00146
Enzymology in Chemical Toxicology: Beyond P450s
Paul F. Hollenberg. Chem Res Toxicol. 2016, 29: 1365-1366. DOI: 10.1021/acs.chemrestox.6b00263
Aberrant Kynurenine Signaling Modulates DNA Replication Stress Factors and Promotes Genomic Instability in Gliomas
April C.L. Bostian and Robert L. Eoff. Chem Res Toxicol. 2016, 29: 1369-1380. DOI: 10.1021/acs.chemrestox.6b00255
Computational Study of the Radical Mediated Mechanism of the Formation of C8, C5, and C4 Guanine:Lysine Adducts in the Presence of the Benzophenone Photosensitizer
Bishnu Thapa, Barbara H. Munk, Cynthia J. Burrows, and H. Bernhard Schlegel. Chem Res Toxicol. 2016, 29: 1396-1409. DOI: 10.1021/acs.chemrestox.6b00057
Identification of Methylated Dithioarsenicals in the Urine of Rats Fed with Sodium Arsenite
Baowei Chen, Xiufen Lu, Lora L. Arnold, Samuel M. Cohen, and X. Chris Le. Chem Res Toxicol. 2016, 29: 1480-1487. DOI: 10.1021/acs.chemrestox.6b00151
What Happens after Activation of Ascaridole? Reactive Compounds and Their Implications for Skin Sensitization
Amar G. Chittiboyina, Cristina Avonto, and Ikhlas A Khan. Chem Res Toxicol. 2016, 29: 1488-1492. DOI: 10.1021/acs.chemrestox.6b0015
Bypass of Mutagenic O6-Carboxymethylguanine DNA Adducts by Human Y- and B-Family Polymerases
Michael H. Räz, Hannah R. Dexter, Christopher L. Millington, Barbara van Loon, David M. Williams, and Shana J. Sturla. Chem Res Toxicol. 2016, 29: 1493-1503. DOI: 10.1021/acs.chemrestox.6b00168
Translesion Synthesis of the N2-2′-Deoxyguanosine Adduct of the Dietary Mutagen IQ in Human Cells: Error-Free Replication by DNA Polymerase κ and Mutagenic Bypass by DNA Polymerases η, ζ, and Rev1
Arindam Bose, Amy D. Millsap, Arnie DeLeon, Carmelo J. Rizzo, and Ashis K. Basu. Chem Res Toxicol. 2016, 29: 1549-1559. DOI: 10.1021/acs.chemrestox.6b00221
Travel Assistance Awards
The Division of Chemical Toxicology sponsors Travel Assistance Awards to students who will present abstracts at the National ACS meeting. The applications are due in June prior to the meeting.
I am a Ph.D. candidate in the Biological Sciences program at Tennessee State studying under the direction of Dr. Margaret Whalen. My current work focuses on investigating the importance of introducing butyltins as stress inducers to the human immune cell environment by understanding whether exposure disrupts any secretory, translational, or transcriptional processing of IL-1ß and IL-6. This work is significant because any disruption of the cytokines may indicate that exposure to butyltin compounds may potentially affect immune competence and cancer invasiveness.
Thanks to the travel award from the Division of Chemical Toxicology, I was able to attend the 252nd American Chemical Society National Meeting and present a portion of my research titled “Dibutyltin Alters IL-1ß and IL-6 Secretion from Human Immune Cells”. This poster highlighted that dibutyltin exposures alter IL-ß and IL-6 secretion from varying cell preparations consisting of natural killer cells, monocyte-depleted peripheral blood mononuclear cells (PBMCs), PBMCs, and granulocytes. We found that elevation of cytokine secretion was seen mostly with IL-1ß compared to IL-6. Future works aim to determine what signaling pathways dibutyltin is utilizing to cause cytokine production.
Attendance at the 252nd American Chemical Society National Meeting was an awesome experience that allowed me to network, attend professional development workshops, and learn more about research opportunities related to my field. I extend my gratitude to the Division of Chemical Toxicology committee for the TOXI travel award, and I look forward to future ACS meetings.
(Best Oral Postdoc Presentation Award)
Currently, I am a postdoctoral fellow in the Burrows Laboratory at the University of Utah, Department of Chemistry. I defended my Ph.D. dissertation in the December of 2014 from the Department of Chemistry, University of Utah. My Ph.D. dissertation focused on the exploration of DNA secondary structures by the alpha-hemolysin protein nanopore, which triggered my great interest in DNA sequencing, leading to my current research project which is sequencing of 8-oxo-7,8-dihydro-2′-deoxyguanosine in the genome by next-generation sequencing methods.
As one of the most common DNA modifications observed during oxidative stress, 8-oxo-7,8-dihydro-2`-deoxyguanosine (dOG), is an oxidation product of 2`-deoxyguanosine (dG). A vast number of previous in vitro studies have identified the mechanisms and sequence contexts for dOG formation; however, these principles have not been validated in the cell. Herein, we developed a method to sequence dOG from genomic samples of mouse origin. As a first step in the data analysis, the sequences allow identification of dOG sites in the genome at a 100-nucleotide resolution. The sequence fragments were analyzed to determine their distribution in the genome. Moreover, the fragment sequences were analyzed to determine if they were enriched with certain motifs, such as runs of dG, G-quadruplexes, or other dG-rich repeat sequences. The results of this initial profile of dOG in the genome allow comparison to predictions from in vitro studies. In the second sequencing experiment, mouse cells with OGG1 knocked out were used as the source of input genomic DNA. Because OGG1 is a first-line repair glycosylase for dOG, the sequences from these cells identify genomic regions in which dOG increases.
The travel award from the Division of Chemical Toxicology allowed me to attend the 252nd American Chemical Society National Meeting. I had a wonderful experience presenting in the Division of Chemical Toxicology. I was excited to share our most recent research results, and colleagues gave me helpful suggestions. The Best Oral Presentation Award was a big surprise to me. Thank you again, TOXI Division!
I received my B.S. degree in Chemistry from Beijing Normal University in China in 2013. I am currently a fourth year Ph.D. candidate in the Department of Chemistry in the laboratory of Dr. Natalia Tretyakova at the University of Minnesota.
Since entering Dr. Tretyakova’s lab, my research focus has been to study the biological effects DNA-protein crosslinks have on DNA replication and transcription and also the repair mechanism of DNA-protein crosslinks. We have been able to develop synthetic methods to synthesize site-specific DNA-protein crosslinks (DPCs), and then use them in in vitro transcription and adduct bypass assays to investigate the effects of DPCs on the fidelity and efficiency of DNA replication and transcription. We were able to show that relatively small DNA-peptide crosslinks can be bypassed by DNA or RNA polymerase and introduce mutations, while large DNA-protein crosslinks completely block DNA and RNA polymerase. Future work aims to study the repair mechanisms of DNA-proteins crosslinks using DNA repair deficient cell lines.
Thanks to the travel award from the Division of Chemical Toxicology, I was able to attend my first ACS meeting at Philadelphia and present a poster entitled “Effects of DNA-protein cross-links on DNA replication and transcription”. It was a great experience for me to receive feedback and suggestions from professors, graduate students, and many industrial scientists. I sincerely thank the Division of Chemical Toxicology for selecting me to receive this travel award and I am looking forward to the next ACS meeting.
I received my M.Sc. in Biophysics at the Zhejiang University, Hangzhou, China. I am currently a Ph.D. student in the Lab of Toxicology lead by Prof. Shana J. Sturla at the ETH Zürich, Switzerland. My research is focused on elucidating the role of gut microbiota on the carcinogenicity of food-borne carcinogenic heterocyclic amines.
I really appreciate the Division of Chemical Toxicology for giving me the opportunity to travel to Philadelphia and present my research. This was my first ACS national meeting and my first oral presentation in a conference. It was an amazing experience to have conversations, get helpful feedback, and exchange ideas with graduate students, postdocs, and professors during the Toxicology Division events. I look forward to the future ACS meetings.
(1st place Poster Presentation Awardee)
I am currently a doctoral candidate in the laboratory of Prof. Penny J. Beuning in the Department of Chemistry and Chemical Biology at Northeastern University in Boston. In the Beuning laboratory, we focus on understanding the underlying principles of cellular responses to DNA damage and the dynamics of proteins involved in DNA replication and repair. I received both my B.S. in Biochemistry and M.S. in Chemistry from Northeastern University. My post-baccalaureate industrial experience included discovering and developing enzymes for genomic research. My first doctoral project was in a collaboration with a medicinal chemistry laboratory. Since multidrug-resistant bacteria are an urgent threat, we focused on optimizing the properties of oxazolidinones, currently active against gram-positive bacteria, for activity against gram-negative bacteria. My research efforts focused on the development of an in vitro transcription/translation assay for screening novel oxazolidinone antibiotics, which target the ribosome.
My current research efforts involve understanding the dynamics of the beta clamp, a ring-shaped protein in Escherichia coli responsible for the high degree of processivity needed for DNA replication. I am very thankful for the travel award from the Division of Chemical Toxicology that allowed me to present a poster on this work titled “Influence of the dynamics of the E. coli beta clamp dimer interface on DNA loading” at the 252nd American Chemical Society meeting in Philadelphia. The ACS meeting provided me with the opportunity to hear the latest research in the field straight from the bench and to receive feedback on my presentation that will boost my research. I was able to expand my professional network, participate in workshops, and learn skills directly from the experts. I extremely grateful to the officers of the division for awarding me the best poster award at the Division of Chemical Toxicology poster session and I look forward to attending future ACS meetings.