ACS 2017 Program

Division of Chemical Toxicology 2017 Program

For the abstracts see our Newsletter.  For a listing of times, see our Newsletter, the ACS Website, or  download this PDF


Chemical Research in Toxicology, Young Investigator Symposium

  • Yinsheng Wang, Univ of California, Riverside. Targeted quantitative proteomic approaches for interrogating the human kinome
  • Kent Gates, Univ of Missouri. Sequence-specific covalent capture for detection of disease-derived nucleic acid sequences
  • Jin Zhang, Univ of California, San Diego. Dynamic visualization of signaling molecules in living cells
  • Huiwang Ai, Chemical Research in Toxicology, Young Investigator Award Winner, Univ of California, Riverside. Seeing is believing: Fluorescent biosensors for redox signaling and oxidative stress

Founders’ Award Symposium.

  • F. Peter Guengerich, Vanderbilt Univ. Biochemical and toxicological applications of mass spectrometry
  • Trevor Penning, Univ of Pennsylvania. Human aldo-keto reductases and aryl hydrocarbon activation
  • Larry Marnett, Vanderbilt Univ. Chemical biology of DNA damage by α,β-unsaturated aldehydes
  • Steve Tannenbaum, MIT. S-Nitrosation is a systems-wide regulatory process
  • Ian Blair, Founders’ Award Winner, Univ of Pennsylvania. Systems pharmacology approach to the study of mitochondrial dysfunction


TOXI Young Investigators Symposium.  Organizer Thomas Spratt, Presiding, Bin Ma and Ujjal Sarkar

  • Lili Guo,, University of Pennsylvania, Effect of statins on HMG-CoA reductase pathway and apolipoprotein A-I production in Friedreich’s ataxia
  • Madjda Bellamri,, University of Minnesota Mechanism of bioactivation of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human prostate
  • Safnas Farwin Abdul Salam,, University of Cincinnati, Novvel class of hydroxyl radical scavenging antioxidants prevents oxidative DNA damage in fibroblast cells exposed to trivalent arsenic
  • Jiabin Wu,, University of California, Riverside, Replicative bypass and mutagenic properties of alkylphosphotriester lesions in Escherichia coli
  • Daniel J. Laverty,, Johns Hopkins University Abasic and oxidized abasic lesion bypass by DNA polymerase theta yields one- and two-nucleotide deletions
  • Stephanie Bamberger, Vanderbilt University Characterization of the 2,6-diamino-4-hydroxy-N5-(methyl)-formamidopyrimidine DNA lesion
  • Timothy A. Coulther,, Northeastern University Engineering a replicative DNA polymerase for specific damage bypass capability
  • Yan Su,, Vanderbilt University School of Medicine Mechanism of ribonucleotide incorporation by human DNA polymerase Eta
  • Liwei Zheng, Johns Hopkins University Independent generation of 2′-deoxyadenosine-N6-yl radical and its reactivity in DNA
  • Matthew Ellis, University of Toledo Investigation into the reactivity of a C5′-uridinyl radical
  • Ji Jiang, Univ of California Riverside Arsenite binds to the RING finger domain of FANCL E3 ubiquitin ligase and inhibits DNA interstrand cross-link repair

Biological Targets of Botanical Supplements. Organizer Judy Bolton

  • Richard van Breemen, Univ of Illinois, at Chicago, Pharmacokinetic Interactions between Drugs and Licorice Botanical Dietary Supplements Used by Menopausal Women
  • Mary F. Paine, Washington State Univ, Intestinal UGTs as targets for pharmacokinetic natural product-drug interactions
  • Tom Kensler, Johns Hopkins. KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
  • Cynthia Rider, NIEHS, Biological Endpoints versus Chemistry in Determining Sufficient Similarity of Botanical Dietary Supplements
  • Judy Bolton, Univ of Illinois, at Chicago, Botanicals modulate estrogen metabolism through multiple targets

Evening SCI-MIX


Crosslink DNA repair. Organizers, Yinsheng Wang and Orlando Scharer

  • Johannes Walter, Harvard Medical School, Mechanisms of replication-coupled repair
  • Kent Gates, Univ. of Missouri, Interstrand cross-links derived from abasic sites in duplex DNA
  • Yinsheng Wang, Univ. of California, Riverside, Occurrence, Replication and repair of DNA interstrand cross-link lesions in human cells.
  • Michael Seidman,NIH/NIA, Baltimore, Lesion proximal FANCD2 is required for replication independent repair of interstrand crosslinks.
  • Xiaohua Peng, Univ. of Wisconsin, Milwaukee, Hydrogen Peroxide Activated DNA Cross-Linking Agents and Their Biomedical Application
  • Lei Li , MD Anderson, Fanconi Anemia pathway and Constitutive Protection of Replication Stress

Toxicological Considerations in Antibody Drug Conjugate Design and Development, Organizers, Fred Guengerich, Nick Meanwell and Griff Humphries

  • Pamela A. Trail, Regeneron, Antibody drug conjugates: design considerations for improving efficacy and safety.
  • Donglu Zhang, Genentech, Antibody drug conjugates (ADC) linker immolation and cell killing activity
  • Omar Ahmad, Pfizer, Development of next generation calicheamicin antibody drug conjugates (ADCs)
  • Peter Senter, Seattle Genetics, Potent antibody-based conjugates for cancer therapy: From early stage research to a clinically approved drug

Keynote Lecture

  • Paul B Watkins, Univ of North Carolina, Understanding hepatoxicity: man to mouse to computer

POSTER SESSION TOXI Buisness Meeting Student and Post-doc Awards


General Oral Papers. Organizer Thomas Spratt, Presiding, Grover Miller and Linlin Zhao

  • Michael P. Stone, Vanderbilt University Chemistry and biology of N5-alkyl-fapy-dG damage in DNA
  • Lisa A. Peterson, Univ of Minnnesota Aldehydes increase the tumorigenic properties of tobacco specific nitrosamines in rodent tumor models
  • Vladimir Shafirovich NYU Unwinding kinetics of carcinogenic adducts: Correlation with processing by nucleotide excision repair machinery
  • Zucai Suo, Ohio State University Structural insights into the post-chemistry steps of nucleotide incorporation catalyzed by a DNA polymerase
  • George-Lucian Moldovan, Pennsylvania State University Central role of PCNA in promoting replication of damaged DNA
  • Linlin Zhao, Central Michigan University Lucidin-dervied N2-guanine DNA lesion is not a major contributor to the mutagenicity of lucidin
  • Lei Li, Indiana University Spore photoproduct within DNA is a surprisingly poor substrate for its designated repair enzyme: The spore photoproduct lyase
  • Antony J. Williams, nvironmental Protection Agency, Real-time prediction of physicochemical and toxicological endpoints using the web-based CompTox Chemistry Dashboard
  • M S. Marques, Universidade de Lisboa Reaction of the antiepileptic drug carbamazepine with bionucleophiles: Bioactivation is not required
  • Kaushik Mitra, Merck and Co. Programed release of nitric oxide, via oxidative metabolism, in animals and humans from clinical candidate MK-8150
  • John H. Lauterbach, Lauterbach Associates Can pipe tobaccos be characterized for regulatory purposes without a puff of pipe smoke?

Advanced mass spectrometric techniques in toxicology. Organizers Silvia Balbo, Peter Villalta

  • Jonathan Josephs, ThermoFisher Scientific, Advances in mass spectrometry techniques for metabolism, pharmacology and toxicology
  • Peter Nemes, George Washington Univ. Capillary Electrophoresis for Trace-level Detection: Metabolites and Proteins.
  • Benedikt Warth, Univ of Vienna, Exposing the Exposome: Utilizing global metabolomics to characterize toxicant exposure and effect.
  • Balasubrahmanyam Addepalli, Univ of Cincinnati, Probing stress-induced effects on RNA and posttranscriptional modifications by LC-MS.
  • Jingshu Guo, Univ. of Minnesota, Advances in human biomonitoring of heterocyclic aromatic amines by high resolution accurate mass