ACS 2017 Program

Division of Chemical Toxicology 2017 Program

For the abstracts see our Newsletter.  For a listing of times, see our Newsletter, the ACS Website, or  download this PDF

SUNDAY

Morning
Chemical Research in Toxicology, Young Investigator Symposium

  • Yinsheng Wang, Univ of California, Riverside. Targeted quantitative proteomic approaches for interrogating the human kinome
  • Kent Gates, Univ of Missouri. Sequence-specific covalent capture for detection of disease-derived nucleic acid sequences
  • Jin Zhang, Univ of California, San Diego. Dynamic visualization of signaling molecules in living cells
  • Huiwang Ai, Chemical Research in Toxicology, Young Investigator Award Winner, Univ of California, Riverside. Seeing is believing: Fluorescent biosensors for redox signaling and oxidative stress

Afternoon
Founders’ Award Symposium.

  • F. Peter Guengerich, Vanderbilt Univ. Biochemical and toxicological applications of mass spectrometry
  • Trevor Penning, Univ of Pennsylvania. Human aldo-keto reductases and aryl hydrocarbon activation
  • Larry Marnett, Vanderbilt Univ. Chemical biology of DNA damage by α,β-unsaturated aldehydes
  • Steve Tannenbaum, MIT. S-Nitrosation is a systems-wide regulatory process
  • Ian Blair, Founders’ Award Winner, Univ of Pennsylvania. Systems pharmacology approach to the study of mitochondrial dysfunction

MONDAY

Morning
TOXI Young Investigators Symposium.  Organizer Thomas Spratt, Presiding, Bin Ma and Ujjal Sarkar

  • Lili Guo,, University of Pennsylvania, Effect of statins on HMG-CoA reductase pathway and apolipoprotein A-I production in Friedreich’s ataxia
  • Madjda Bellamri,, University of Minnesota Mechanism of bioactivation of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human prostate
  • Safnas Farwin Abdul Salam,, University of Cincinnati, Novvel class of hydroxyl radical scavenging antioxidants prevents oxidative DNA damage in fibroblast cells exposed to trivalent arsenic
  • Jiabin Wu,, University of California, Riverside, Replicative bypass and mutagenic properties of alkylphosphotriester lesions in Escherichia coli
  • Daniel J. Laverty,, Johns Hopkins University Abasic and oxidized abasic lesion bypass by DNA polymerase theta yields one- and two-nucleotide deletions
  • Stephanie Bamberger, Vanderbilt University Characterization of the 2,6-diamino-4-hydroxy-N5-(methyl)-formamidopyrimidine DNA lesion
  • Timothy A. Coulther,, Northeastern University Engineering a replicative DNA polymerase for specific damage bypass capability
  • Yan Su,, Vanderbilt University School of Medicine Mechanism of ribonucleotide incorporation by human DNA polymerase Eta
  • Liwei Zheng, Johns Hopkins University Independent generation of 2′-deoxyadenosine-N6-yl radical and its reactivity in DNA
  • Matthew Ellis, University of Toledo Investigation into the reactivity of a C5′-uridinyl radical
  • Ji Jiang, Univ of California Riverside Arsenite binds to the RING finger domain of FANCL E3 ubiquitin ligase and inhibits DNA interstrand cross-link repair

Afternoon
Biological Targets of Botanical Supplements. Organizer Judy Bolton

  • Richard van Breemen, Univ of Illinois, at Chicago, Pharmacokinetic Interactions between Drugs and Licorice Botanical Dietary Supplements Used by Menopausal Women
  • Mary F. Paine, Washington State Univ, Intestinal UGTs as targets for pharmacokinetic natural product-drug interactions
  • Tom Kensler, Johns Hopkins. KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
  • Cynthia Rider, NIEHS, Biological Endpoints versus Chemistry in Determining Sufficient Similarity of Botanical Dietary Supplements
  • Judy Bolton, Univ of Illinois, at Chicago, Botanicals modulate estrogen metabolism through multiple targets

Evening SCI-MIX

TUESDAY

Morning
Crosslink DNA repair. Organizers, Yinsheng Wang and Orlando Scharer

  • Johannes Walter, Harvard Medical School, Mechanisms of replication-coupled repair
  • Kent Gates, Univ. of Missouri, Interstrand cross-links derived from abasic sites in duplex DNA
  • Yinsheng Wang, Univ. of California, Riverside, Occurrence, Replication and repair of DNA interstrand cross-link lesions in human cells.
  • Michael Seidman,NIH/NIA, Baltimore, Lesion proximal FANCD2 is required for replication independent repair of interstrand crosslinks.
  • Xiaohua Peng, Univ. of Wisconsin, Milwaukee, Hydrogen Peroxide Activated DNA Cross-Linking Agents and Their Biomedical Application
  • Lei Li , MD Anderson, Fanconi Anemia pathway and Constitutive Protection of Replication Stress

Afternoon
Toxicological Considerations in Antibody Drug Conjugate Design and Development, Organizers, Fred Guengerich, Nick Meanwell and Griff Humphries

  • Pamela A. Trail, Regeneron, Antibody drug conjugates: design considerations for improving efficacy and safety.
  • Donglu Zhang, Genentech, Antibody drug conjugates (ADC) linker immolation and cell killing activity
  • Omar Ahmad, Pfizer, Development of next generation calicheamicin antibody drug conjugates (ADCs)
  • Peter Senter, Seattle Genetics, Potent antibody-based conjugates for cancer therapy: From early stage research to a clinically approved drug

Evening
Keynote Lecture

  • Paul B Watkins, Univ of North Carolina, Understanding hepatoxicity: man to mouse to computer

POSTER SESSION TOXI Buisness Meeting Student and Post-doc Awards

WEDNESDAY

Morning
General Oral Papers. Organizer Thomas Spratt, Presiding, Grover Miller and Linlin Zhao

  • Michael P. Stone, Vanderbilt University Chemistry and biology of N5-alkyl-fapy-dG damage in DNA
  • Lisa A. Peterson, Univ of Minnnesota Aldehydes increase the tumorigenic properties of tobacco specific nitrosamines in rodent tumor models
  • Vladimir Shafirovich NYU Unwinding kinetics of carcinogenic adducts: Correlation with processing by nucleotide excision repair machinery
  • Zucai Suo, Ohio State University Structural insights into the post-chemistry steps of nucleotide incorporation catalyzed by a DNA polymerase
  • George-Lucian Moldovan, Pennsylvania State University Central role of PCNA in promoting replication of damaged DNA
  • Linlin Zhao, Central Michigan University Lucidin-dervied N2-guanine DNA lesion is not a major contributor to the mutagenicity of lucidin
  • Lei Li, Indiana University Spore photoproduct within DNA is a surprisingly poor substrate for its designated repair enzyme: The spore photoproduct lyase
  • Antony J. Williams, nvironmental Protection Agency, Real-time prediction of physicochemical and toxicological endpoints using the web-based CompTox Chemistry Dashboard
  • M S. Marques, Universidade de Lisboa Reaction of the antiepileptic drug carbamazepine with bionucleophiles: Bioactivation is not required
  • Kaushik Mitra, Merck and Co. Programed release of nitric oxide, via oxidative metabolism, in animals and humans from clinical candidate MK-8150
  • John H. Lauterbach, Lauterbach Associates Can pipe tobaccos be characterized for regulatory purposes without a puff of pipe smoke?

Afternoon
Advanced mass spectrometric techniques in toxicology. Organizers Silvia Balbo, Peter Villalta

  • Jonathan Josephs, ThermoFisher Scientific, Advances in mass spectrometry techniques for metabolism, pharmacology and toxicology
  • Peter Nemes, George Washington Univ. Capillary Electrophoresis for Trace-level Detection: Metabolites and Proteins.
  • Benedikt Warth, Univ of Vienna, Exposing the Exposome: Utilizing global metabolomics to characterize toxicant exposure and effect.
  • Balasubrahmanyam Addepalli, Univ of Cincinnati, Probing stress-induced effects on RNA and posttranscriptional modifications by LC-MS.
  • Jingshu Guo, Univ. of Minnesota, Advances in human biomonitoring of heterocyclic aromatic amines by high resolution accurate mass