Postdoctoral position in the Section on Gene Targeting,
Laboratory of Molecular Gerontology
The National Institute on Aging (NIA), a major research component of the National Institutes of Health (NIH) and the Department of Health and Human Services (DHHS), is recruiting for a postdoctoral position in the Section on Gene Targeting, Laboratory of Molecular Gerontology.
Replication of the genome is hindered by numerous impediments, including alternate DNA structures, protein DNA complexes, and chemical adducts. Failure to overcome them can result in cell death, cellular senescence, and/or genomic rearrangements which may be cancer inducing. Understanding how normal and tumor cells respond to these challenges is the subject of intense investigation. We have discovered a novel replication restart pathway through which replisomes overcome replication blocks (Mol. Cell 52, 434, 2013; Cell Reports, 27, 1794, 2019). The new pathway is driven by two different versions of the replisome, active in different stages of S phase. Currently we are defining the enzymes and accessory factors that support the pathway and the importance for normal and challenged replication.
A postdoctoral position to participate in this program is available for an individual with training in chemistry, biochemistry, or molecular biology, and an interest in the cellular response to replication stress and genome integrity.
Candidates must have a Ph.D. or M.D. with less than five years of relevant postdoctoral experience. Salary is commensurate with experience and accomplishments. Submit letter of interest, curriculum vitae, and references to: Michael Seidman, Ph.D., Chief, Section on Gene Targeting, Laboratory of Molecular Gerontology, NIA-NIH, Laboratory of Molecular Gerontology, 251 Bayview Blvd, Baltimore, MD 21224 USA. E-mail: firstname.lastname@example.org.
Postdoctoral Fellow Position in Proteomics
Department of Chemistry at the University of California, Riverside
A postdoctoral position is available in Dr. Linlin Zhao’s laboratory at the Department of Chemistry of the University of California, Riverside. The postdoctoral fellow will work on an NIH-funded project focused on understanding the mechanism of mitochondrial DNA degradation (please see recent publications, PMIDs 31413200, 31627882). The laboratory has strong expertise in protein biochemistry, enzymology, DNA damage and repair, and mitochondrial genomic maintenance. Molecular biology, mammalian cell culture, proteomics techniques are also used. For details, please visit https://zhaolab.ucr.edu.
The position offers an excellent training opportunity in mitochondrial biology with an emphasis on biochemistry, quantitative proteomics, and bioinformatics approaches. Besides, the fellow will have the opportunity to hone his/her skills in scientific communication, student supervising, and lab management. We welcome and support scientists with diverse backgrounds who are energetic and highly motivated for career advancement.
UC Riverside has a vibrant research environment (including 12 current NAS members and 2 Nobel Laureates). The Zhao Lab is housed in the state-of-the-art Multidisciplinary Research Building, UCR’s newest and largest research building. The campus is close to other universities, research institutes, and biotech industries in Southern California. Riverside was recently named as one of America’s top ten Most Livable Communities, with ample cultural and entertainment opportunities in a safe and affordable community. The Pacific Ocean is located about 1-hour west of campus, while the San Bernardino Mountains and ski areas are located about 1-hour east. The city offers all the cultural advantages of any U.S. city, together with the fantastic all-year-round weather of sunny Southern California.
A successful candidate should have a doctoral degree in analytical chemistry, biochemistry, molecular biology, or related field, and a strong background in proteomics. A candidate with a strong background in quantitative proteomics or proximity-based labeling methods is preferred.
Appointment, salary, and benefits
Appointment period: One year, renewable annually for up to four years.
Salary: Postdoctoral salary is commensurate upon qualifications and 2-step higher than NIH NRSA stipends.
Other benefits: Health insurance
Postdoctoral scholars are automatically members of the Riverside Postdoc Association (RPA), which is an active community that seeks to engage with postdocs to improve and promote their welfare and interests living in Riverside and working at UCR. Upon arrival, every postdoc is invited to contact RPA to meet new contacts, receive tips for living in Riverside, and participate in cultural and recreational activities organized by the association.
Interested applicants should send a CV, a 1-page research statement, and the names/contact information of three references to Dr. Zhao at email@example.com.
posted December 18, 2019
Postdoctoral Research Fellowship to Study Mechanisms of Drug Allergy and Hypersensitivity
Merck Research Laboratories
Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.
Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.
The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
Position Overview: As a postdoctoral fellow in Molecular & Investigative Toxicology you will work with a highly collaborative and interdisciplinary team of scientists to apply understanding of fundamental mechanisms to solve drug development problems relating to drug hypersensitivity reactions. You will conceive, design, plan and implement a research program that will enable the creation of a preclinical testing strategy that can identify the immune mediated hypersensitivity potential of new drug candidates.
Responsibilities: Monitor, evaluate and leverage new technologies that enable preclinical de-risking of compounds. Investigate mechanisms of immune related safety concerns raised in animal toxicology studies to help inform on relevance to humans. Lead the development and implementation of assays and protocols that enable de-risking of human safety findings that surface in human clinical trials and are not seen in conventional animal studies. Publish as primary or lead author in high quality, peer-reviewed, scientific journals
Educational and Skill Requirements: PhD in Pharmacology, Toxicology or related life science or met all the requirements for a PhD by June 2019, with 3 years or less postdoctoral experience. Experience with assay development and innovation, ability to design experiments, interpret and enable further development of a project. Superior written and oral communication and interpersonal skills with an ability to work effectively in a team environment
Preferred Experience and Skills: Demonstrated ability to publish in peer-reviewed journals. Expertise with any of the following: Analytical techniques: LCMS, Proteomics, ELISPOT, ELISA, flow cytometry, tissue culture
Our employees are the key to our company’s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. Merck is an equal opportunity employer, M/F/D/V – proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard & Reserves – We value your past and present service.
Dr. James Monroe
Senior Principal Scientist
Merck Research Laboratories
WP45-333, Sumneytown Pike
West Point, PA 19486
posted August 16, 2019
Position is available for a highly motivated Bio-analytical Chemist to develop sensitive assays for studying DNA base modifications (adducts) as biomarkers for cancer and to conduct translational research using clinical samples. Training in biological research is a plus.
The candidate should be a recent Ph.D. Depending on the qualifications, the candidate will be considered for postdoctoral fellow or junior faculty (i.e. Instructor or Research Assistant Professor) position.
This work will be conducted at the Lombardi Comprehensive Cancer Center of Georgetown University Medical Center in Washington DC.
Please send CV to Dr. Chung at firstname.lastname@example.org
posted June 11, 2019
Several postdoctoral positions available for recent Ph.D. graduates interested in learning how to use mass spectrometry to investigate DNA modifications, repair, and DNA-protein interactions. We are supported by 4 NIH grants. We recently purchased a high resolution Orbitrap QE instrument, in addition to existing triple quadrupole MS – it will be available for this work. We are located in a new beautiful Cancer Center building housing active investigators and core facilities including analytical biochemistry, genomics, and flow cytometry, all with state of the art equipment.
University of Minnesota has a very strong chemical biology, chemical carcinogenesis, and epigenetics community, and is an excellent environment for postdoctoral training. It does get cold in the winter, but we make the best of it by going skiing, ice skating, and enjoying the music and culture of the Twin cities. Summers are amazing, with many opportunities for outdoor recreation. Minneapolis is an extremely bike friendly city, and biking trails are amazing!
Principal Investigator: Natalia Tretyakova, Ph.D., Professor of Medicinal Chemistry, University of Minnesota Tel. 612-626-3432, e-mail email@example.com
posted March 18, 2019
Postdoctoral position, Stephen S. Hecht laboratory
University of Minnesota
A postdoctoral position is available in the Hecht Laboratory for projects investigating mechanisms and prevention of cancer induced by tobacco products, e-cigarettes, and environmental carcinogens. These projects, supported by grants from the National Cancer Institute, will determine the structures of metabolites and DNA addition products formed upon exposure to carcinogens found in tobacco products, e-cigarettes, and the general environment. The laboratory uses state of the art mass spectrometry approaches and related highly sensitive analytical chemistry techniques to investigate metabolism and DNA adduct formation in exposed humans and laboratory animals.
A Ph.D. or equivalent degree in organic chemistry, biochemistry, analytical chemistry or a closely related field. Familiarity with mass spectrometry and other highly sensitive chemical analytical techniques.
To apply, send your CV with the names of three references to Stephen S. Hecht (firstname.lastname@example.org)
posted March 8, 2019
Institute for Basic Science
Center for Genomic Integrity
Ulsan, South Korea
The Center for Genomic Integrity (CGI) of Institute of Basic Science (IBS) at UNIST in Ulsan, Korea invites applications for post-doctoral research associates. The successful applicant will conduct research in the Chemical and Cancer Biology Branch (CCBB). CGI-IBS is a recently established research center belonging to IBS, a national research institute to enable top notch basic science research of Korea, and aims to be one of the leading institutes in the world in the area of DNA repair and genomic integrity.
The successful candidate will have the opportunity to perform active research in one of the following sections, which share one big laboratory, resources and a collaborative spirit.
Molecular Cancer Research Section (PI: Kei-ichi Takata): DNA double strand break repair, DNA mutations in cancer cells, DNA polymerase theta (POLQ), DNA helicase HELQ.
DNA Damage Repair Section (PI: Jung Eun Yeo): Molecular mechanisms of nucleotide excision repair, Canonical and non-canonical roles of the Fanconi anemia pathway.
Cancer Therapeutics Mechanism Section (PI: Orlando D. Schärer): DNA interstrand crosslink formation and repair, connections of DNA repair pathways with cancer therapy.
We offer significant resources to conduct research, state of the art facilities, core and technical support and an intellectually stimulating and highly interactive environment. Our research is intrinsically interdisciplinary and employs biochemistry, molecular, structural, cellular and cancer biology, as well as organic chemistry. For more information please consult the CCBB website (www.chemicalcancerbiology.org).
– Ph. D. in biochemistry, cell biology, organic chemistry or related fields.
– Strong record of productive and creative research demonstrated by publications in peerreviewed
journals and presentations at scientific conferences.
– Highly motivated to conduct top level research.
Appointment and Benefits
The initial appointment will be for one year with the possibility of extension of up to a total of
five years. We offer competitive salary and on campus housing and relocation help is available.
All classes at UNIST are conducted in English and our campus has many international
researchers. Ulsan is a thriving city located between the ocean and mountains and is
conveniently located to explore Korea and Asia.
How to apply
Interested candidates should submit a letter of interest, curriculum vitae, and the names of three
references in a single pdf file to Orlando Schärer at: email@example.com
Postdoctoral Researcher in Environmental Toxicology
The Turesky laboratory at the University of Minnesota, Minneapolis is looking for a postdoctoral researcher to develop and validate methods for biomarkers of carcinogen DNA adducts. Hands-on-training and proficient knowledge in liquid chromatography/mass spectrometry (LC/MS), MS/MS, sample preparation and workup, and analytical chemistry are required. Experiences in employing nanoLC, nanoESI, triple quadrupole, ion trap and high-resolution MS instruments, training in chemical syntheses/derivatization, bioinformatics, cell culture techniques, DNA or protein biomarker development are highly desired. For further information, please contact: Dr. Rob Turesky (Tel. 612-626-0141, Email: Rturesky@umn.edu)
posted April 17, 2018
Web sites of interest for Chemical Toxicology job seekers
American Association for the Advancement of Science
Society of Toxicology
The SOT website has a valuable Resource Guide to Careers in Toxicology