Events

American Chemical Society Meetings

254th ACS National Meeting, August 20-24, 2017, Washington, DC

Program Committee Chair: Thomas E Spratt, Department of Biochemistry and Molecular Biology, Pennsylvania State University.

256th ACS National Meeting, August 19-23, 2018, Boston, MA

Program Committee Chair: Thomas E Spratt, Department of Biochemistry and Molecular Biology, Pennsylvania State University.

258th ACS National Meeting, August 25-29, 2019, San Diego

Program Committee Chair: TBA.

260th ACS National Meeting, August 23 – 27, 2020, San Francisco, California

Program Committee Chair: TBA.

262nd ACS National Meeting, August 22-26, 2021, Atlanta, Georgia

Program Committee Chair: TBA.

Purpose.   The award was established in honor of the founders of the Division and recognizes scientists whose work exemplifies the founders’ vision of excellence in the field of chemical toxicology. Nominees should be members of the Division of Chemical Toxicology whose scientific activities have emphasized innovative research in the general field of chemical toxicology.

Nature.  The Award consists of a plaque and the recipient will organize a Symposium at the American Chemical Society National Meeting.  The symposium will culminate with the recipient presenting the Richard Loeppky Lecture.

Dick Loeppky
Dick Loeppky

The Richard Loeppky Lecture.  Richard Loeppky began studying nitrosamine chemistry in the mid 1960s.  In the ensuing decades, Loeppky’s group used the tools of mechanistic chemistry to shed light on carcinogenic N-nitroso compounds. His work centered on the definition of the bioactivation pathways of environmental and metabolically-generated ß-oxidized nitrosamines and the exploration of new nitrosation mechanisms for the generation of endogenous and exogenous nitrosamines.

Loeppky’s research in the field of nitrosamine carcinogenesis led to his central role in conceiving and establishing the Division of Chemical Toxicology. In the early 1990s, he and others recognized that there was no appropriate venue for the presentation of work in this field.  This led to the idea that chemical toxicology could be represented by a new division of ACS.  Loeppky’s dedication to the cause was substantial. He was instrumental in developing a petition, recruiting a leadership group and, most importantly, obtaining permission from various ACS committees and individuals to mount a drive for a new division. He also secured the approval of the existing ACS divisions and the ACS president. The division was granted probationary status and presented its first program at the Orlando meeting of the ACS in August 1996.

With this Lecture, we honor the creativity, enthusiasm, and the work of Richard Loeppky.

History. The award was established in 2008 by the Executive Committee of the Division of Chemical Toxicology.  The past winners are listed below.

2008 Lawrence J  Marnett

2009:  Stephen S Hecht

2010 Richard Loeppky

2011 F. Peter Guengerich

2012:  Thomas Baillie

2013:  Steve Tannenbaum

2014:  Paul Hollenberg

2015:  Arthur Grollman

2016:  Nicholas Geacintov and Suse Broyde

Rules of Eligibility.  The awardee will be a member of the Division of Chemical Toxicology.

Nominations.  Nominations are sought by the Awards Committee each fall for the presentation at the following fall meeting of the American Chemical Society Meeting.

A nomination document should include:

  1. Nomination letter containing an evaluation of the nominee’s accomplishments, innovative research into Chemical Toxicology.
  2. The candidates CV with a list of publications and patents.

Nominations should be submitted as a single PDF file (Name the PDF file with candidate’s name, for example: LawrenceMarnett_FoundersNomination.pdf)

 

 

crt-titleChemical Research in Toxicology sponsors a Young Investigator’s Award and Symposium at the American Chemical Society’s national Meeting

Nature.  The Award consists of a plaque and the recipient will organize a Symposium at the American Chemical Society National Meeting.

Eligibility: Candidates should be within 15 years of having received a Ph.D.

History.  The past winners are:

2012:  Yinsheng Wang

2013:  Dean Naisbitt

2014:  Shana Sturla

2015:  Penny Beuning

2016:  Yimon Aye

Nominations: Nomination packet will consist of a nomination letter plus the candidate’s CV and may include up to two seconding letters. Nominations will carry over for two additional years as long as the nominee still meets eligibility requirements.

All nomination material should be sent electronically to:
Chemical Research in Toxicology Editorial Office: eic@crt.acs.org.

The Division of Chemical Toxicology (TOXI) will make available Travel Assistance Awards to undergraduate and graduate students and postdoctoral researchers. The awards of approximately $750 will reimburse travel and hotel costs for the National ACS meeting in Washington DC this August (receipts will be required). Applications will be awarded on the basis of financial need, scientific merit, and diversity factors. Preference will be given to first-time attendees.

All students and postdocs who are members or affiliates of TOXI and who have submitted an abstract to the TOXI program at National ACS meeting  are eligible to apply.

The application should consist of a single pdf file containing:

  1. A nomination letter from the faculty advisor or laboratory director. The letter should explain why Travel Assistance Award funds are needed.
  2. A curriculum vitae for the applicant.
  3. The abstract for the work to be presented by the nominee at the meeting.

Applications are due to Thomas Spratt (tes13@psu.edu)  by July 1, 2018.

The Program Committee will evaluate proposals based on their ability to attract and engage a large audience, timeliness, and appropriateness for the Division of Chemical Toxicology.

The Executive Committee seeks proposals that span the interests, and fully reflect the diversity of the membership in the Division. Therefore, selection of speakers should be balanced when considering gender, groups historically underrepresented in the profession, research area, employment sector, and career stage.

  • Proposals are due on July 15 ONE YEAR prior to the meeting where the session is requested.  For example, for a symposium in Fall 2018, the due date is July 15, 2017.
  • Proposals should be a maximum of ONE page (12 point font, 0.5 inch margins).

The proposal must contain (see the Template/example below):

  • A symposium title.
  • A paragraph stating the idea behind the proposal, why it is timely,  how this symposium will differ from those recently given at TOXI, and  why TOXI is the appropriate forum for this symposium. (Chemical mechanisms of toxicology)
  • Indicate your willingness to organize this symposium at a different (later) time than originally proposed.
  • A list of potential speakers, preferably with tentative titles (4-6 speakers is a typical number submitted).
  • The names of several alternative speakers for the session should be included.
  • The speaker’s status should be listed as outlined in the template
    Please use the template provided below for the proposal.
    E-mail national meeting symposia proposals to Thomas E. Spratt
  • Proposals will usually be considered for a half-day session only.
  • Academic speakers are eligible for reimbursement of reasonable travel expenses
  • Industrial speakers are eligible for reimbursement on a case-by-case basis.
  • Speakers working for the government or a non-profit institution are eligible for reimbursement.
  • Typical reimbursement for an academic speaker would include:
    • Travel – Non-refundable round trip coach airfare to the meeting (usually up to $500).
  • ACS members are expected to pay their own registration fees.  Non-ACS members can get reimbursed for a one-day registration.
    • Accommodation – Two night’s stay in a hotel (please choose one from the ACS list, if possible).
  • Miscellaneous – Other reasonable travel expenses (taxi, tolls, etc.), but not meals, during the trip.
  • Reimbursement amount outside the guidelines is at the discretion of the session organizer and Divisional Treasurer.
  • Symposium organizers are eligible for reimbursement within the above guidelines.
  • The symposium organizer will collect all original receipts from the speakers, and submit them to Secretary-Treasurer using the reimbursement form.

Any funds that are raised by the organizer are technically donated to the TOXI, which formally funds the symposia at the National Meetings. Symposium organizers should manage the overall expenses for their symposium on behalf of the TOXI, so please be sure to let the speakers understand the guidelines before the symposium to avoid misunderstandings.

As an organizer, it is your responsibility to determine the distribution of available funds. This is critical when there are not enough funds to pay all of the expenses encumbered by invited speakers. In this case, you must indicate to the Secretary/Treasurer the level of partial reimbursements to be accorded to each speaker.

SUNDAY MORNING

Chemical Research in Toxicology Young Investigator Award-Invited, Oral

Y. Aye, Organizer, Presiding

8:30 Introductory Remarks.

8:45 Protein Modification by Lipid Electrophiles and Its Consequences. L.J. Marnett, J. Camarillo, W.N. Beavers, J. Galligan

9:15 Reactivity of damaged DNA in nucleosomes. M.M. Greenberg

9:45 Succinylation and SIRT5 as Important Regulators of Heart Function. H. Lin

10:15 Intermission.

10:30 T-REX™ on-demand redox targeting: A toolset for functional discoveries and validations. S. Parvez, M.J. Long, H. Lin, Y. Zhao, J. Haegele, V. Pham, D. Lee, Y. Aye

11:00 Master and Commander of the Cellular Antioxidant Response. J.R. Poganik, Y. Aye

11:30 Switching gears: ribonucletoide reductase antagonizes cell proliferation. Y. Aye

SUNDAY AFTERNOON

Founders Award Lecture & Symposium-Invited, Oral

S. Broyde, N. E. Geacintov, Organizers, Presiding

1:30 Introductory Remarks.

1:40 Regulation of dual incision and repair synthesis in human nucleotide excision repair. O.D. Scharer, F. Adebanke, J. Rageul

2:15 Impact of Structural Features of DNA Lesions on their Recognition and Repair by the Human Nucleotide Excision Repair System. N.E. Geacintov

2:50 Elucidating Structure-Function Relationships in Lesion- Containing DNA: Insights from Molecular Modeling Integrated with Experiment. S. Broyde

3:25 Intermission.

3:45 Insights into the DNA damage recognition by the Rad4/XPC nucleotide excision repair complex. J. Min, A. Ansari, X. Chen, Y. Velmurugu

4:20 DNA damage and repair in chromatin: Finding the keys to get in. P. Mao, M. Duan, J. Wyrick, M. Smerdon

Increasing the Value of Water Monitoring Data for Pesticide Fate & Effects Evaluations- Oral

Sponsored by AGRO, Cosponsored by ENVR and TOXI

MONDAY MORNING

Young Investigators Symposium-Oral

U. Sarkar, Organizer, Presiding

8:00 Parsing the conformational and configurational equilibria of a 2′-deoxyribosylurea DNA adduct. A.H. Kellum, V. Jasti, A.K. Basu, M.P. Stone

8:20 Mutagenic and cytotoxic properties of the O2-alkylthymidine lesions in human cells. J. WU, P. Wang, L. Li, Y. Wang

8:40 Investigation of RNA oxidation via selective generation of a C5′-uridinyl radical. M. Ellis, A.C. Bryant-Friedrich

9:00 Quantitative Assessment of the Biological Consequences and Repair of Carboxymethylated and Ethylated DNA Adducts. C. You, P. Wang, S. Nay, j. wang, x. dai, T. O’Connor, Y. Wang

9:20 Sequencing of 8-oxo-7,8-dihydro-2’-deoxyguanosine in the genome by next-generation sequencing methods. Y. Ding, A.M. Fleming, C.J. Burrows

9:40 Intermission.

9:50 Transcriptional Bypass of O2-alkylthymidine Lesions by T7 RNA Polymerase and Human RNA Polymerase II. N. Williams, P. Wang, Y. Wang

10:10 Tracing androgen metabolism with inhibition of aromatase in breast cancer: in vitro studies, clinical correlates and implications for acquired resistance. L. Bottalico, L. Gil de Gomez, Q. Wang, A. Frey, N. Snyder, I.A. Blair

10:30 Metatranscriptomics Reveals Functional Effects of Diazinon Exposure on Gut Microbiome. B. Gao, X. Bian, L. Chi, P. Tu, K. Lu

10:50 Toxicological study of quinone–protein adducts by molecular modeling and spectroscopic analysis. M.S. Elgawish

11:10 Cadmium inactivates a zinc-dependent endonuclease of the human mismatch repair pathway. S.M. Sherrer, P.L. Modrich

11:30 Replication Studies of C3’-Epimeric Lesions of 2‘-Deoxyribonucleosides in E. coli cells. P. Wang, N.J. Amato, Y. Wang

Increasing the Value of Water Monitoring Data for Pesticide Fate & Effects Evaluations- Oral

Sponsored by AGRO, Cosponsored by ENVR and TOXI

Agrochemicals & Pollinators: Current Science & Risk Assessment Approaches-Poster

Sponsored by AGRO, Cosponsored by AGFD, ENVR and TOXI

MONDAY AFTERNOON

Asbestos Fate, Exposure, Remediation, & Adverse Health Effects

I. A. Blair, Organizer, Presiding

1:30 Overview: Penn Superfund Research and Training Program Center: Asbestos, fate, transport, remediation and adverse health effects. T.M. Penning

2:10 Fate of asbestos in soil: remediation prospects and paradigm. J. Willenbring, S. Mohanty , A. Salamatipour, C. Gonneau, D. Jerolmack, B. Casper

2:40 Aggregate dynamics and their control on the mobility of asbestos in the environment. D. Jerolmack, L. Wu, C. Ortiz, J. Willenbring

3:10 Historic cohort study to identify effects of chrysotile asbestos exposure on past residents of Ambler, PA. E. Emmett, A. Agawu, S. Elahi, F. Barg, D. Wiebe

3:40 Intermission.

3:55 Mouse models of malignant mesothelioma. J. Testa, C. Menges, M. Cheung, Y. Kadariya, J. Talarchek, R.A. Pietrofesa, R. Simmons, M. Christofidou-Solomidou, S. Albelda

4:25 Chemopreventive properties of LGM2605. M. Christofidou-Solomidou, R.A. Pietrofesa, A. Velalopoulou, S. Albelda

4:55 Biomarkers of asbestos exposure. I.A. Blair, L. Weng, C. Mesaros, N. Snyder, W. Hwang, A. Vachani

Increasing the Value of Water Monitoring Data for Pesticide Fate & Effects Evaluations- Oral

Sponsored by AGRO, Cosponsored by ENVR and TOXI

TUESDAY MORNING

Chemical Toxicology in the Study of Health Disparities among Ethnic/Racial Groups- Invited, Oral

S. Balbo, S. S. Hecht, Organizers, Presiding

8:30 Introductory Remarks.

8:35 Differing frequencies of clinically relevant genomic alterations (CRGA) in with colorectal cancers of patients to define disparities in outcomes. E.P. Mitchell

9:15 Relationships between body burden of contaminants, biomarkers of effects and health outcomes among Inuit in the Canadian Arctic. L.H. Chan

9:55 Unconventional Gas and Oil Drilling Operations (UGOD) in the Marcellus Shale and Health Disparities. T.M. Penning

10:35 Intermission.

10:50 Individual variation in human arsenic biotransformation: Intuitive and puzzling determinants drive variability. W. Klimecki

11:30 Analysis of nicotine and tobacco smoke toxicant and carcinogen metabolites in relation to ethnic differences in lung cancer susceptibility in cigarette smokers. S.S. Hecht, S. Park, S. Carmella, D.O. Stram, C.A. Haiman, L. Le Marchand, S.E. Murphy

12:10 Concluding Remarks.

Agrochemicals & Pollinators: Current Science & Risk Assessment Approaches-Oral

Sponsored by AGRO, Cosponsored by AGFD, ENVR and TOXI

Increasing the Value of Water Monitoring Data for Pesticide Fate & Effects Evaluations- Poster

Sponsored by AGRO, Cosponsored by ENVR and TOXI

TUESDAY AFTERNOON

Needs & Directions for the Future of Toxicology in Pharmaceutical Development- Invited, Oral

Cosponsored by MEDI Y. Will, Organizer F. Guengerich, W. G. Humphreys, Organizers, Presiding

1:30 Introductory Remarks.

1:35 Update on recent approaches to improve drug design practices. N.A. Meanwell

2:15 Risk assessing bioactivation: a pharmaceutical challenge. R.A. Thompson

2:55 Small Molecule Safety Lead Optimization and Candidate Identification: Integrating Technologies into Decision-Making. D. Dambach

3:35 Learnings from early-safety assessment in the pharmaceutical industry. Y. Will

Agrochemicals & Pollinators: Current Science & Risk Assessment Approaches-Oral

Sponsored by AGRO, Cosponsored by AGFD, ENVR and TOXI

TUESDAY EVENING

Division of Chemical Toxicology Keynote Address-Invited, Oral

P. F. Hollenberg, Organizer, Presiding

5:00 Introductory Remarks.

5:10 From repair replication to R-loops in half-a-century. P.C. Hanawalt

General Poster Session-Poster

A. C. Bryant-Friedrich, Organizer

6:30 – 8:30

Automation of an empirically-based decision tree for developmental and reproductive toxicity (DART). C. Coolbaugh Lester, J. Fisher, M. Laufersweiler, J. Naciff, G. Daston, K. Blackburn, S. Wu

Impact of gold nanoparticles coated with a new class of polyelectrolyte on Zebrafish (Danio rerio) “a model aquatic organism”. K. Noland, Z. Zheng, I. Gunsolus, C.L. Haynes, N. Niemuth, R. Klaper, Z. Rosenzweig

Next generation sequencing based cytotoxicity and mutagenicity studies on arylamine adducts in cell. K. Bian, F. Chen, Q. Tang, A. Cai, B. Cho, D. Li

Chemical biology and toxicology of human carboxylesterase 1 in macrophages. M.K. Ross, L. Mangum, J. Lee, A. Borazjani, J. Crow

Effects of asbestos exposure on mitochondrial metabolites in lung cells. L. Weng, C. Mesaros, N. Snyder, I.A. Blair

Avoidance of the AMES test liability for aryl-amines via computation, 5 years on.. L. Whitehead, P.R. McCarren, S. Glowienke, A. Werner

Tetra-Ethylene Glycol Coated Gold Nanoparticles Are Stable And Have An Extended Half-Life In Vivo. J. Willett, M. Lawrence, J. Wilder, O. Smithies

Do grinding conditions affect the toxicity of asbestos fibers?. A. Salamatipour, S.K. Mohanty, R.A. Pietrofesa, D. Vann, M. Christofidou-Solomidou, J. Willenbring

Mineral Calomel (Mercury(I) Chloride): A Poison in the Byzantine Empire?. M.R. Chávez, M. Golas, A. Mousavi

Read-across at the crossroad of chemoinformatics and regulatory science. A. Mostrag- Szlichtyng , I.J. Boyer, B. Bienfait, B. Heldreth, T. Kleinoder, J. Marusczy, A. Tarkhov, O. Sacher, C.H. Schwab, V. Vitcheva, J. Rathman, C. Yang

Nucleosome histone tail conformation and dynamics: impacts of lysine acetylation and a nearby minor groove benzo[a]pyrene-derived lesion. I. Fu, Y. Cai, Y. Zhang, N.E. Geacintov, S. Broyde

Impact of lesion stereochemistry on histone tail structure in a nucleosome core particle: a molecular dynamics study. Y. Cai, Y. Fu, N.E. Geacintov, S. Broyde

Effect of DNA-protein cross-links on transcription. S. Ji, N.Y. Tretyakova

Conformation-driven translesion synthesis of a bulky DNA lesion: thermodynamic, binding, and computational investigation. A. Cai, K.A. Wilson, S.D. Wetmore, B. Cho

XPC lesion recognition mechanism in nucleotide excision repair. H. Mu, N.E. Geacintov, Y. Zhang, S. Broyde

Oncometabolites inhibit AlkB family DNA repair enzymes. Q. Tang

Mutagenicity and toxicity assay studying effect of oncometabolites 2-hydroxyglutarate on AlkB family DNA repair enzymes. F. Chen, K. Bian, Q. Tang, D. Li

DNA polymerase ν pre-steady-state kinetic studies of the fidelity and bypass of adducts derived from tobacco specific nitrosamines. P. Aladahalli Sanne Gowda

Effects of copper on replication block and mutagenicity in-cell on AlkB family DNA repair enzymes. Z. Humulock, K. Bian, F. Chen, Q. Tang, D. Li

Dynamics of the E. coli beta-clamp dimer interface on DNA loading. B. Koleva, J. Conway, J. Compton, J. Donlan, J. Han, A. Wu, P.J. Beuning

Gut Microbiome and Metabolome Response to Artificial Sweeteners. X. Bian, B. Gao, K. Lu, L. Chi, P. Tu

Sex-specific Effects of Arsenic Exposure on the Trajectory and Function of the Gut Microbiome. L. Chi

Effects of nicotine on the gut microbiome and its metabolic functions. P. Tu, R. Mahbub, X. Bian, B. Gao, L. Chi, K. Lu

Inhaled Aldehydes Increase Lung Tumor Formation in the NNK Induced A/J Mouse Tumor Model. M.K. Oram, D. Seabloom, M.G. O’Sullivan, Y. Ho, L. Zhang, S.S. Hecht, S. Balbo, L.A. Peterson

Identification of pyridyloxobutyl deoxycytidine adducts formed in the reaction of DNA with 4- (acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone. A.K. Michel, P. Upadhyaya, S.S. Hecht

Identification of adducts formed by pyridyloxobutylation of deoxyadenosine and DNA by 4- (acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens. P. Upadhyaya, E. Carlson, A.K. Michel, S.S. Hecht

Synthesis, stability, and in vitro analysis of nitrosamides resulting from cytochrome P450- mediated oxidation of N’-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone. E.S. Carlson, P. Upadhyaya, S.S. Hecht

Enantiomeric composition of N’-nitrosonornicotine in the urine of smokers and smokeless tobacco users. J. Yang, S.S. Hecht

Effect of Variable Power levels on the Yield of Total Aerosol Mass and Formation of Aldehydes in E-Cigarette Aerosols. I.G. Gillman, K.A. Kistler, E. Stewart, A. Paolantonio

Improved method for the analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts by liquid chromatography nanoelectrospray-high resolution tandem mass spectrometry. B. Ma, C. Ruszczak, V. Jain, S.S. Khariwala, R. Dove, I. Stepanov

Investigation of DNA Lesions from C5’-Oxidation. S.H. Cho, S.A. Audat, A.C. Bryant- Friedrich

Rapid Throughput DNA Extraction from Formalin-Fixed Paraffin-Embedded Tissues for Quantification of Multi-Class Carcinogenic DNA Adducts. B. Yun, J. Guo, S. Xiao, T.A. Rosenquist, A.P. Grollman, R. Turesky

Replication of double-stranded plasmid vectors containing interstrand DNA-DNA cross-links generated by the reaction of a deoxyguanosine residue with an opposing abasic site. N.E. Price, Y. Wang

Chemical syntheses and Characterizations of Oligodeoxyribonucleotides Containing Site-specifically Incorporated Alkylphosphotriester Lesions. J. Wu, Y. Wang

Synthesis of oligonucleotides containing Fapy-dG and N5-(2-oxoethyl)Fapy dG adducts. C.K. Malik, C.J. Rizzo

Probing Arylamine-DNA adducts using Ru(II) polypyridyl complexes. N. Thangavel, V. Vaidyanathan

Mass spectrometric analysis of post-translational modifications in hemoglobin from type 2 diabetes mellitus patients. H.C. Chen, Y. Yang, P. Chen

Abasic site cross-link discovery and quantification via stepped MRM in rat tissue. A novel approach to identify DNA modifications in organisms. R. Hillebrand, M.J. Catalano, S. Mohapatra, S. Senvo, R. Lee, K.S. Gates, P.C. Dedon

LC-MS determination and pharmacokinetic study of lonidamine in a mouse model of melanoma. L. Guo, K. Nath, D.S. Nelson, .C. Roman, C. Mesaros, J.D. Glickson, I.A. Blair

Inhibition of cytochrome P450 by buckminsterfullerene. P.M. Gannett, C. Bostick, T.S. Tracy, E.L. Dolan, A.R. Biundo, W.D. Tish

Epigenetic Regulation of Cytosine Methylation, Hydroxymethylation, Formylation and Carboxylation in a Mouse Model of Smoking-Induced Lung Cancer. C. Seiler, J. Song, A. Anandharaj, F. Kassie, N.Y. Tretyakova

Biomonitoring the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in hair and prostate by ultra performance liquid chromatography-mass spectrometry. S. Xiao, S. Krishnamachari, C. Weight, R. Turesky

Quantification of Azaserine-induced Carboxymethylated and Methylated DNA Lesions in Cells by Nanoflow Liquid Chromatography-Nanoelectrospray Ionization Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method. Y. Yu, j. wang, P. Wang, Y. Wang

Distinct metabolomic profiles in inbred mouse strains and correlation with iron. R. Zeidan, D. Medina-Cleghorn, K. Page, S. McLachlan, E. Eskin, D. Nomura, C. Vulpe

High Throughput Analysis of Orlistat® Drug Standard and Corresponding Non-Prescription Over-The-Counter Drug alli® using TSKgel ODS-140HTP, 2.3µm Columns using HPLC and UHPLC. C. Benner, A. Chakrabarti

Dibutyltin Alters Interleukin 1 beta and Interleukin 6 Secretion from Human Immune Cells. S. Brown, S. Tehrani, W. Wilburn, M. Whalen

Estrogen receptor-mediated PAH o-quinone toxicity. I.G. Lee, T. Zang, D.H. Tamae, M. Huang, T.M. Penning

Dissipation Monitoring of the QCM-D to Study Ligand- Induced Cell Signaling. J.Y. Chen, M. Garcia, L.S. Penn, J. Xi

Pilot study of malathion, atrazine, carbaryl and chlorpyrifos in the breast milk of women in suburban and agricultural communities of Central Florida. m. bourgeois, J.C. Tovar, E. Pulster, R. Harbison

Quantification of alkaloids in areca nut-containing products by liquid chromatography-tandem mass-spectrometry. V. Jain, A. Garg, P. Chaturvedi, M. Parascandola, I. Stepanov

WEDNESDAY MORNING

General Oral Session-Oral

A. C. Bryant-Friedrich, Organizer Z. Suo, Presiding

8:00 Gut microbes and probiotics anaerobically transform carcinogenic dietary heterocyclic amines to metabolites with altered toxicity. J. ZHANG, C. Engels, M. Schneider, M. Fekry, C. Lacroix, S.J. Sturla

8:20 Mitigating CYP TDI Ensuing from Bioactivation of Fluoropyrimidine Moiety. M. Mandal

8:40 Rapid detection of endocrine disrupting chemicals by a nanosensor at ultra-sensitive level. N. Le, X. Wang, Y. Geng, R. Tang, G. Yesilbag Tonga, Z. Jiang

9:00 New techniques for determination of e-cigarette aerosol pH and nicotine absorption by saliva. J.H. Lauterbach, . Lauterbach

9:20 N2-Benzyl-2’-deoxyguanosine 5’-triphosphate is a specific substrate for human DNA polymerase ?. T. Spratt, A. Prakasha Gowda

9:40 Pyridylhydroxybutyl DNA phosphate adduct formation in rats treated chronically with the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. B. Ma, A.T. Zarth, P.W. Villalta, P. Upadhyaya, I. Stepanov, S.S. Hecht

10:00 Intermission.

10:10 Delivering The Benefits of Chemical-Biological Integration in Computational Toxicology at the EPA. A.J. Williams, K. Mansouri, C. Grulke, K. Houck, D. Lyons, J. Edwards, M. Martin, J. Wambaugh, G. Tier, I. Shah, R. Judson, K. Crofton, R. Thomas

10:30 Metalloporphyrins and salens as mimics of the cytochrome p-450 mixed oxidase systems to evaluate toxicity of drug metabolites. M. Chorghade

10:50 Biomarkers of heterocyclic aromatic amines for molecular epidemiology studies. R.J. Turesky, Y. Wang, K. Pathak, S. Xiao, C. Weight, M. Malfatti, K. Turteltaub, K. White, L. Wilkens, L. Le Marchand

11:10 Chemistry and biology of N5-alkyl-Fapy-dG lesions. M.P. Stone, M. Egli, R.S. Lloyd, A. Mc Cullough, C.J. Rizzo, R.J. Turesky

11:30 Murder of John Bell: Reviewing a 200 year old paranormal murder mystery through the eyes of a chemical toxicologist. M. Mann

11:50 Using yeast to test the effect of CYPs on the toxicity of certain chemicals. R. Zeidan, R. Ma, R.A. Rudel, J. Ackerman, A. Loguinov, M. Tagmount, C. Vulpe, M. Fasulo

Computational Chemistry & Toxicology in Chemical Discovery & Assessment (QSARs)- Oral

Sponsored by AGRO, Cosponsored by COMP, ENVR and TOXI

WEDNESDAY AFTERNOON

DNA Repair & Its Role in Defining Human Susceptibility to Disease-Invited, Oral

Financially supported by NIEHS N. Y. Tretyakova, Organizer, Presiding

1:30 Introduction.

1:35 Repair of OG:A mismatches: From chemistry to MUTYH-associated polyposis and back again. S.S. David

2:15 Single molecule studies of DNA base excision repair. Z. Suo

2:55 DNA sculpting and moving metals in DNA repair nuclease specificity. S. Tsutakawa, J. Tainer

3:35 Intermission.

3:50 Replicative and translesion synthesis DNA polymerases in the repair of DNA interstrand crosslinks. U. Roy, S. Mukherjee, A. Sharma, O.D. Scharer

4:30 CELLULAR REPAIR OF DNA-PROTEIN CONJUGATES. N.Y. Tretyakova, A. Groehler, S. Ji, C. Campbell

Computational Chemistry & Toxicology in Chemical Discovery & Assessment (QSARs)- Oral

Sponsored by AGRO, Cosponsored by COMP, ENVR and TOXI

THURSDAY MORNING

Innovations in Human Health Exposure & Risk Assessment-Oral

Sponsored by AGRO, Cosponsored by ENVR and TOXI

Division of Chemical Toxicology 2017 Program

For the abstracts see our Newsletter.  For a listing of times, see our Newsletter, the ACS Website, or  download this PDF

SUNDAY

Morning
Chemical Research in Toxicology, Young Investigator Symposium

  • Yinsheng Wang, Univ of California, Riverside. Targeted quantitative proteomic approaches for interrogating the human kinome
  • Kent Gates, Univ of Missouri. Sequence-specific covalent capture for detection of disease-derived nucleic acid sequences
  • Jin Zhang, Univ of California, San Diego. Dynamic visualization of signaling molecules in living cells
  • Huiwang Ai, Chemical Research in Toxicology, Young Investigator Award Winner, Univ of California, Riverside. Seeing is believing: Fluorescent biosensors for redox signaling and oxidative stress

Afternoon
Founders’ Award Symposium.

  • F. Peter Guengerich, Vanderbilt Univ. Biochemical and toxicological applications of mass spectrometry
  • Trevor Penning, Univ of Pennsylvania. Human aldo-keto reductases and aryl hydrocarbon activation
  • Larry Marnett, Vanderbilt Univ. Chemical biology of DNA damage by α,β-unsaturated aldehydes
  • Steve Tannenbaum, MIT. S-Nitrosation is a systems-wide regulatory process
  • Ian Blair, Founders’ Award Winner, Univ of Pennsylvania. Systems pharmacology approach to the study of mitochondrial dysfunction

MONDAY

Morning
TOXI Young Investigators Symposium.  Organizer Thomas Spratt, Presiding, Bin Ma and Ujjal Sarkar

  • Lili Guo,, University of Pennsylvania, Effect of statins on HMG-CoA reductase pathway and apolipoprotein A-I production in Friedreich’s ataxia
  • Madjda Bellamri,, University of Minnesota Mechanism of bioactivation of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human prostate
  • Safnas Farwin Abdul Salam,, University of Cincinnati, Novvel class of hydroxyl radical scavenging antioxidants prevents oxidative DNA damage in fibroblast cells exposed to trivalent arsenic
  • Jiabin Wu,, University of California, Riverside, Replicative bypass and mutagenic properties of alkylphosphotriester lesions in Escherichia coli
  • Daniel J. Laverty,, Johns Hopkins University Abasic and oxidized abasic lesion bypass by DNA polymerase theta yields one- and two-nucleotide deletions
  • Stephanie Bamberger, Vanderbilt University Characterization of the 2,6-diamino-4-hydroxy-N5-(methyl)-formamidopyrimidine DNA lesion
  • Timothy A. Coulther,, Northeastern University Engineering a replicative DNA polymerase for specific damage bypass capability
  • Yan Su,, Vanderbilt University School of Medicine Mechanism of ribonucleotide incorporation by human DNA polymerase Eta
  • Liwei Zheng, Johns Hopkins University Independent generation of 2′-deoxyadenosine-N6-yl radical and its reactivity in DNA
  • Matthew Ellis, University of Toledo Investigation into the reactivity of a C5′-uridinyl radical
  • Ji Jiang, Univ of California Riverside Arsenite binds to the RING finger domain of FANCL E3 ubiquitin ligase and inhibits DNA interstrand cross-link repair

Afternoon
Biological Targets of Botanical Supplements. Organizer Judy Bolton

  • Richard van Breemen, Univ of Illinois, at Chicago, Pharmacokinetic Interactions between Drugs and Licorice Botanical Dietary Supplements Used by Menopausal Women
  • Mary F. Paine, Washington State Univ, Intestinal UGTs as targets for pharmacokinetic natural product-drug interactions
  • Tom Kensler, Johns Hopkins. KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
  • Cynthia Rider, NIEHS, Biological Endpoints versus Chemistry in Determining Sufficient Similarity of Botanical Dietary Supplements
  • Judy Bolton, Univ of Illinois, at Chicago, Botanicals modulate estrogen metabolism through multiple targets

Evening SCI-MIX

TUESDAY

Morning
Crosslink DNA repair. Organizers, Yinsheng Wang and Orlando Scharer

  • Johannes Walter, Harvard Medical School, Mechanisms of replication-coupled repair
  • Kent Gates, Univ. of Missouri, Interstrand cross-links derived from abasic sites in duplex DNA
  • Yinsheng Wang, Univ. of California, Riverside, Occurrence, Replication and repair of DNA interstrand cross-link lesions in human cells.
  • Michael Seidman,NIH/NIA, Baltimore, Lesion proximal FANCD2 is required for replication independent repair of interstrand crosslinks.
  • Xiaohua Peng, Univ. of Wisconsin, Milwaukee, Hydrogen Peroxide Activated DNA Cross-Linking Agents and Their Biomedical Application
  • Lei Li , MD Anderson, Fanconi Anemia pathway and Constitutive Protection of Replication Stress

Afternoon
Toxicological Considerations in Antibody Drug Conjugate Design and Development, Organizers, Fred Guengerich, Nick Meanwell and Griff Humphries

  • Pamela A. Trail, Regeneron, Antibody drug conjugates: design considerations for improving efficacy and safety.
  • Donglu Zhang, Genentech, Antibody drug conjugates (ADC) linker immolation and cell killing activity
  • Omar Ahmad, Pfizer, Development of next generation calicheamicin antibody drug conjugates (ADCs)
  • Peter Senter, Seattle Genetics, Potent antibody-based conjugates for cancer therapy: From early stage research to a clinically approved drug

Evening
Keynote Lecture

  • Paul B Watkins, Univ of North Carolina, Understanding hepatoxicity: man to mouse to computer

POSTER SESSION TOXI Buisness Meeting Student and Post-doc Awards

WEDNESDAY

Morning
General Oral Papers. Organizer Thomas Spratt, Presiding, Grover Miller and Linlin Zhao

  • Michael P. Stone, Vanderbilt University Chemistry and biology of N5-alkyl-fapy-dG damage in DNA
  • Lisa A. Peterson, Univ of Minnnesota Aldehydes increase the tumorigenic properties of tobacco specific nitrosamines in rodent tumor models
  • Vladimir Shafirovich NYU Unwinding kinetics of carcinogenic adducts: Correlation with processing by nucleotide excision repair machinery
  • Zucai Suo, Ohio State University Structural insights into the post-chemistry steps of nucleotide incorporation catalyzed by a DNA polymerase
  • George-Lucian Moldovan, Pennsylvania State University Central role of PCNA in promoting replication of damaged DNA
  • Linlin Zhao, Central Michigan University Lucidin-dervied N2-guanine DNA lesion is not a major contributor to the mutagenicity of lucidin
  • Lei Li, Indiana University Spore photoproduct within DNA is a surprisingly poor substrate for its designated repair enzyme: The spore photoproduct lyase
  • Antony J. Williams, nvironmental Protection Agency, Real-time prediction of physicochemical and toxicological endpoints using the web-based CompTox Chemistry Dashboard
  • M S. Marques, Universidade de Lisboa Reaction of the antiepileptic drug carbamazepine with bionucleophiles: Bioactivation is not required
  • Kaushik Mitra, Merck and Co. Programed release of nitric oxide, via oxidative metabolism, in animals and humans from clinical candidate MK-8150
  • John H. Lauterbach, Lauterbach Associates Can pipe tobaccos be characterized for regulatory purposes without a puff of pipe smoke?

Afternoon
Advanced mass spectrometric techniques in toxicology. Organizers Silvia Balbo, Peter Villalta

  • Jonathan Josephs, ThermoFisher Scientific, Advances in mass spectrometry techniques for metabolism, pharmacology and toxicology
  • Peter Nemes, George Washington Univ. Capillary Electrophoresis for Trace-level Detection: Metabolites and Proteins.
  • Benedikt Warth, Univ of Vienna, Exposing the Exposome: Utilizing global metabolomics to characterize toxicant exposure and effect.
  • Balasubrahmanyam Addepalli, Univ of Cincinnati, Probing stress-induced effects on RNA and posttranscriptional modifications by LC-MS.
  • Jingshu Guo, Univ. of Minnesota, Advances in human biomonitoring of heterocyclic aromatic amines by high resolution accurate mass

DIVISION OF CHEMICAL TOXICOLOGY

Thomas Spratt, Program Chair

SUNDAY MORNING

Translesion DNA Polymerases

Z. Suo, Organizer, Presiding

8:30 Introductory Remarks.

8:35 . Mechanisms to Coordinate Multiple DNA Polymerases for TLS. M.A. Trakselis

9:15 . Explosive mutation accumulation triggered by heterozygous human Pol å proofreading- deficiency is driven by suppression of mismatch repair. Z.F. Purcell

9:55 Intermission.

10:10 . Finding their way: How error-prone polymerases gain access to the bacterial replisome. J.J. Loparo

10:50 . Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA Polymerase. R. Vayas, G. Efthimiopoulos, J. Tokarsky, C. Malik, A.K. Basu, Z. Suo

SUNDAY AFTERNOON

Founders’ Award

Cosponsored by PROF
J. L. Bolton, Organizer, Presiding

1:00 Introductory Remarks.

1:10 . Biological targets of electrophilic furan metabolites. L.A. Peterson

1:50 . Mass spectrometry studies of DNA and protein adducts of reactive electrophiles. N.Y. Tretyakova

2:30 . Electrophilic targeting of Keap1/Nrf2 signalling for disease prevention and treatment. A. Dinkova-Kostova, T. Honda, A.Y. Abramov

3:10 Intermission.

3:25. Chasing Rainbows? Targeted covalent ligand design guided by precision electrophile signaling technologies. Y. Aye

4:05 . Botanicals electrophiles modify multiple targets. J.L. Bolton

Innovations in Chemistry Supporting Strategic Human Health Risk Assessments

Sponsored by AGRO, Cosponsored by CHAS and TOXI

MONDAY MORNING

Student/Post-Doc

E. G. Prestwich, U. Sarkar, Organizers, Presiding

8:00 . Repair and processing of DNA lesions induced by a dynamic electrophile. S. Byrne, K. Yang, S. Rokita

8:20 . Mechanisms of bioactivation of the tobacco carcinogens and 2-amino-9H-pyrido[2,3- b]indole (AáC) and 4-aminobiphenyl (4-ABP) in human bladder.. M. Bellamri, L. Yao, R. Turesky

8:40 . Development of a novel approach for measuring N’-nitrosnornicotine bioactivation in humans by using deuterium-labeled analogs. E. Carlson, A. Goode, V. Gurvich, I. Stepanov, V. Jain, P. Upadhyaya, S.S. Hecht

9:00 . A scheduled LC-SRM method for targeted DNA adductome analysis. Y. Cui, P. Wang, Y. Wang

9:20 Intermission.

9:30 . Significant impact of divalent metal ions on the fidelity, sugar selectivity, and drug incorporation efficiency of human PrimPol. J. Tokarsky, P. Wallenmeyer, K. Phi, Z. Suo

9:50 . Incorporating histone H2A variants facilitates global excision of uracil residues in nucleosomes. C. Li, S. Delaney

10:10. Integrating multi-“omics”- mass spectrometry-based methods to characterize electronic cigarette exposure in humans. R.P. Dator, P.W. Villalta, C.J. Hooyman, L.A. Maertens, S. Balbo

10:30 . The C’5-pseudouridinyl radical. I. Sappy

10:50 Intermission.

11:00 . Transcriptional inhibition and repair mechanism of alkyl phosphotriester DNA adducts in mammalian cells. Y. Tan, J. Wu, Y. Wang

11:20 . Mass spectroscopy-based metabolomics reveals new insights on the biological effects of copper oxide nanoparticles in a human colon carcinoma cell line. N.G. Chavez Soria, D.S. Aga, G. Atilla-Gokcumen

11:40 . A Sensitive Method for Quantitation of Abasic Sites in Isolated and Cellular DNA byElectrospray Ionization Tandem Mass Spectrometry. H. Chen, C.J. Rizzo, R.J. Turesky

MONDAY AFTERNOON

Chemical Toxicology of Nanomaterials

S. Balbo, Organizer, Presiding

1:00 Introductory Remarks.

1:05. The Future of Nanotoxicology Research: Filling Knowledge Gaps to Safeguard Health. A. Elder

1:45.  Investigation of toxicity mechanism of nano-scale lithium battery material NMC to bacterial models. V. Feng

2:25. The size, surface chemistry and reactivity – all matter as toxicity determinants of fibrous nanomaterials. A.A. Shvedova

3:05 Intermission.

3:20. DNA methylation alterations by nanoparticles. L. Godderis

4:00. Nanomaterial Induced Mechanisms: Focus on Nano Cell Interactions. A. Kraegeloh

MONDAY EVENING

Sci-Mix

T. Spratt, Organizer

8:00 – 10:00

Modified 3-deaza-3-alkyl-adenosines as minor groove alkylation mimics in translesion DNA synthesis. L.J. Weselinski, V. Begoyan, G. Kenyon, M. Tanasova

Ultrasensitive high-resolution mass spectrometric analysis of methyl DNA phosphate adducts in human lung. B. Ma, P.W. Villalta, J.B. Hochalter, I. Stepanov, S.S. Hecht

Application of an in silico tool for the risk assessment of an industrial process compliant to ICH M7 guidelines. M. Burns, M. Ott, S.J. Webb

Structural and dynamic impact of single ribonucleotide incorporation on nucleosome structure.I. Fu, D. Smith, S. Broyde

Identification of photo-degradation products of nitroguanidine and toxicological implications. L. Moores, A. Kennedy, K.A. Gust, M.K. Shukla, L.K. Rabalais, D.L. Henderson, S.J. Jones

Efficiency of Initiating Base Excision Repair on Nucleosome Substrates. A. Garlow, S. Delaney

Nanomaterials in marine environment: toxicity to Artemia salina with and without the presence of Phe and Cd2+. J. Lu, X. Lv, Z. Chen, X. Zhu

Initiation of repair of DNA nucleobase lesions in the nucleosome core particle. M.E. Tarantino, S. Delaney

High-resolution/accurate mass DNA adductomics to screen for doxorubicin-induced adducts as biomarkers of therapeutic efficacy. A. Stornetta, K. Walters, R.P. Dator, V. Guidolin, P.W. Villalta, S. Balbo

Molecular level studies of the impact of poly (oxonorbornenes) and their gold nanoparticles conjugates on D. rerio. embryos. J.N. Klutts, A. Laranang, Z. Zheng, J. Saar, K. Lienkamp, R. Brewster, Z. Rosenzweig

Determining the basis of E. coli DinB and human pol kappa DNA damage specificity. H. Stern, T.A. Coulther, J. Winters, C.L. Mills, M.J. Ondrechen, P. Beuning

DNA damage induced by oxidative stress and lipid peroxidation in leukocyte DNA from African-American and Caucasian smokers. C. Ruszczak, B. Ma, J. Jensen, D. Hatsukami, I. Stepanov

Potential DNA oxidation adducts for disease biomarkers. N.C. Wamer, E.A. Carlson, T.A. Dodson, E.G. Prestwich

Investigation of the effect of 2-phenethyl isothiocyanate (PEITC) on the levels of 4-hydroxy-1- (3-pyridyl)-1-butanone-releasing DNA adducts in oral cells of smokers. A. Jain, G. Yakovlev, B. Ma, I. Stepanov

Petrogenic and pyrogenic polycyclic aromatic hydrocarbons in human urine: comparison of their levels between two geographic regions. C. Mesaros, M. Huang, L.C. Hackfeld, R.P. Hodge, I.A. Blair, T.M. Penning

Surface-modified gold nanoparticles and their long-term impact on cellular pathways. P. Falagan Lotsch, E. Grzincic, C.J. Murphy

Independent Synthesis and Fate of DNA Lesions Generated from Oxidative Damage at the C-3 and C-5 Position of Deoxyribonucleotides. M. Bedi, A.C. Bryant-Friedrich

EB-Fapy-dG adducts of 1,3-butadiene: synthesis, structural identification, and detection in human cells. S.S. Pujari, A. Groehler, D. Najjar, N.Y. Tretyakova

Smoking and inflammation mediated epigenetic changes in a mouse model of lung cancer. J. Fernandez, C. Seiler, Q. Han, N.Y. Tretyakova

Inter-individual differences in metabolism of 1,3-butadiene. A. Degner, G. Madugundu, R. Arora, L.A. Peterson, N.Y. Tretyakova

TUESDAY MORNING

Mechanisms of Binding, Transport & Biotransformation of Toxic Metals

Cosponsored by INOR
B. P. Rosen, Organizer, Presiding

8:30 . Control of metal geometries within de novo designed three-stranded coiled coils. T. Pinter, L. Ruckthong, C. Ervin, V.L. Pecoraro

9:15 . ArsI, a C-As lyase for degradation of environmental organoarsenicals. V.S. Nadar, M. Yoshinaga, B.P. Rosen

10:00 . Understanding the Mechanism of Carbon-Metal Bond Cleavage by the Organomercurial Lyase MerB.. H. Wahba, M. Stevenson, D. Wilcox, J.G. Omichinski

10:45 . Interplay of copper transport proteins in the processing of platinum anticancer drugs in the cell. N. Dolgova, C. Yu, O. Dmitriev

TUESDAY AFTERNOON

Chemical Research in Toxicology Young Investigator Award

W. Chan, Organizer, Presiding

1:00 Introductory Remarks.

1:10 . Oxidized polyunsaturated fatty acids: Are they toxic or bioactive?. J. Lee

1:50 . Antibiotics induce nitrosative stress in microorganisms. C.T. Chan

2:30 Intermission.

2:45. Advances in Human Biomonitoring of Carcinogens by Ion Trap and High Resolution Accurate Mass Spectrometry. R. Turesky

3:25. Chemical approaches to investigate the toxicity of aristolochic acids. W. Chan

Keynote Lectures

T. Spratt, Organizer
N. E. Geacintov, Presiding

4:30 Introductory Remarks.

4:40. Linking mutational spectra of chemical carcinogens to the mutational patterns seen in human tumors. J. Essigmann, B.I. Fedeles

TUESDAY EVENING

Posters

T. Spratt, Organizer

7:00 – 9:00

Prediction of carcinogenic behavior of hexacyclic polycyclic aromatic hydrocarbons using aromatic sextet theory and ionization potentials. J.O. Ona Ruales

Toxic Effects and Molecular Mechanism of Silver Nanoparticles to Daphnia magna. J. Hou

Modified 3-deaza-3-alkyl-adenosines as minor groove alkylation mimics in translesion DNA synthesis. L.J. Weselinski, V. Begoyan, G. Kenyon, M. Tanasova

Ultrasensitive high-resolution mass spectrometric analysis of methyl DNA phosphate adducts in human lung. B. Ma, P.W. Villalta, J.B. Hochalter, I. Stepanov, S.S. Hecht

Screening for DNA Adducts in Human Colon by High-Resolution Nano-ESI UHPLC/MSn. D. Konorev, R. Turesky

Application of an in silico tool for the risk assessment of an industrial process compliant to ICH M7 guidelines. M. Burns, M. Ott, S.J. Webb

Methylation in human hemoglobin is associated with age as analyzed by liquid chromatography tandem mass spectrometry. H.C. Chen, S. Ip

Characterizing Uracil DNA Glycosylase Processivity in Nucleosome Core Particles. E. Kennedy, S. Delaney

Structural and dynamic impact of single ribonucleotide incorporation on nucleosome structure. I. Fu, D. Smith, S. Broyde

Identification of photo-degradation products of nitroguanidine and toxicological implications. L. Moores, A. Kennedy, K.A. Gust, M.K. Shukla, L.K. Rabalais, D.L. Henderson, S.J. Jones

Gallic acid derivatives inhibit DNA repair enzyme ALKBH2. Q. Tang, F. Chen, H. Ma, K. Bian, D. Li

Conformation-specific replication block from bulky 4-aminobiphenyl-modified DNA lesions. A. Cai, K. Bian, F. Chen, D. Li, B. Cho

Mutagenicity of DNA-Peptide Crosslink in Human cells. S. Naldiga, S. Ji, G. Moldovan, N.Y. Tretyakova, A.K. Basu

Efficiency of Initiating Base Excision Repair on Nucleosome Substrates. A. Garlow, S. Delaney

Replication studies of N3-methyladenine in Escherichia coli cells. J. Yuan, Y. Wang

Unmasking the role of protein modification in the observed toxicity of aristolochic acid. C. Chan, W. Chan

Adverse reactions induced by the antiepileptic drug oxcarbazepine may stem from its metabolic biotransformation to carbamazepine. I. Martins, C. Charneira, M. Marques, A. Antunes

Identification of 4-(methylnitroamino)-1-(3-pyridyl-1-oxide)-1-butanone, a novel metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rat urine. L. von Weymarn, R. Dator, S. Balbo, S.E. Murphy

Initiation of repair of DNA nucleobase lesions in the nucleosome core particle. M.E. Tarantino, S. Delaney

Dual cell system for in vitro studies of toxic blood gases. W.G. Senanayake, I. Petrikovics, D.E. Thompson

Analysis of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human lung DNA from smokers and nonsmokers. J. Yang, S. Balbo, P.W. Villalta, S.S. Hecht

High-resolution/accurate mass DNA adductomics to screen for doxorubicin-induced adducts as biomarkers of therapeutic efficacy. A. Stornetta, K. Walters, R.P. Dator, V. Guidolin, P.W. Villalta, S. Balbo

Molecular level studies of the impact of poly (oxonorbornenes) and their gold nanoparticles conjugates on D. rerio. embryos. J.N. Klutts, A. Laranang, Z. Zheng, J. Saar, K. Lienkamp, R. Brewster, Z. Rosenzweig

Oxidation and Removal of Cytosine Derivatives in the Nucleosome. P. Caffrey, S. Delaney

Determining the basis of E. coli DinB and human pol kappa DNA damage specificity. H. Stern, T.A. Coulther, J. Winters, C.L. Mills, M.J. Ondrechen, P. Beuning

Prediction of the interaction region between the Y-family polymerase DinB and the transcription-repair coupling factor Mfd in E. coli. S.K. Fields, P. Beuning

Machine learning models for predicting hepatic steatosis based on in vivo data. B. Zdrazil, S. Jain, S. Klinting, S. Escher, G.F. Ecker, U. Norinder

Predicting drug metabolites using bacterial-based models. P.C. Rosado, J.P. Cruz, M.C. Justino, M. Marques, G.C. Justino

pCharacterization of LexA-regulated protein YbfE in E. coli. A. Hotchkiss, C. Kramer, P. Beuning

DNA damage induced by oxidative stress and lipid peroxidation in leukocyte DNA from African-American and Caucasian smokers. C. Ruszczak, B. Ma, J. Jensen, D. Hatsukami, I. Stepanov

p Analysis of the spectrum of DNA modifications in Pseudomonas aeruginosa. E.A. Carlson, N.C. Wamer, T.A. Dodson, E.G. Prestwich

Probing the conformational dynamics of the Beta sliding clamp in Escherichia coli. M.L. Liriano, B. Koleva, P. Beuning

Potential DNA oxidation adducts for disease biomarkers. N.C. Wamer, E.A. Carlson, T.A. Dodson, E.G. Prestwich

Rapid microplate assay for acellular reactive oxygen species generation induced by engineered nanomaterials in real-time. R. Coreas, W. Zhong

Identifying toxicology concepts in the replacement of mercury catalysts during the acetylene hydrochlorination of vinyl chloride monomers. L. Green, J. Marshall, A.S. Cannon

Petrogenic and pyrogenic polycyclic aromatic hydrocarbons in human urine: comparison of their levels between two geographic regions. C. Mesaros, M. Huang, L.C. Hackfeld, R.P. Hodge, I.A. Blair, T.M. Penning

Dissecting interactions between E. coli DNA polymerase III and single-stranded DNA binding protein to gain insights into polymerase management. J. McIsaac, m. ondrechen, P.J. Beuning

Release of lead (Pb) and formation of disinfection byproducts during drinking water disinfection in the water distribution system. J. Liu, V.K. Sharma, C.M. Sayes

Mineralogy dependent dissolution of inhaled uranium in simulated lung fluids in uranium mine lands, New Mexico. E. Hettiarachchi, S. Paul, D. Cadol, B. Frey, G. Rubasinghege

Reactive oxygen species (ROS)-dependent release of an inhibitor from an aptamer. G. Premnauth, E.J. Merino

Effect of surface charge on toxicity of AuNPs; Are cationic AuNPs toxic?. E. Lee, Y. Kwon

Nanomaterials in marine environment: toxicity to Artemia salina with and without the presence of Phe and Cd2+. J. Lu, X. Lv, Z. Chen, X. Zhu

Molecular characterization of alcohol-induced DNA damage for cancer prevention. V. Guidolin, A. Carra’, P.W. Villalta, E. Carlson, S. Balbo

EB-Fapy-dG adducts of 1,3-butadiene: synthesis, structural identification, and detection in human cells. S.S. Pujari, A. Groehler, D. Najjar, N.Y. Tretyakova

Inter-individual differences in metabolism of 1,3-butadiene. A. Degner, G. Madugundu, R. Arora, L.A. Peterson, N.Y. Tretyakova

2, 2’, 3, 5’, 6 polychlorinated biphenyls (PCB-95) induce behavioral and GABAgenic neurotransmitter changes in zebrafish at early developmental exposure. P. Ranasinghe, C.M. Lee

Investigation of the effect of 2-phenethyl isothiocyanate (PEITC) on the levels of 4-hydroxy-1- (3-pyridyl)-1-butanone-releasing DNA adducts in oral cells of smokers. A. Jain, G. Yakovlev, B. Ma, I. Stepanov

Smoking and inflammation mediated epigenetic changes in a mouse model of lung cancer. J. Fernandez, C. Seiler, Q. Han, N.Y. Tretyakova

Independent Synthesis and Fate of DNA Lesions Generated from Oxidative Damage at the C-3’and C-5′ Position of Deoxyribonucleotides. M. Bedi, A.C. Bryant-Friedrich

Ecotoxicology of nano-perovskites in aquatic environment. T. Zhou, W. Fan

Thermodynamic exposure reduction by amendment techniques to limit bioaccumulation during ongoing depositional input – a sediment mesocosm study with three organisms. A.P. Wang

MegaTox for Predicting Compound Liabilities. K.M. Zorn, T. Lane, D.P. Russo, A. Clark, S. Ekins

Information-Derived Adverse Outcome Pathways with a Case Study on Structural Cardiotoxicity. A. Bender

Morphology-dependent cytotoxicity of SiC nanomaterials to human mesenchymal stem cells. F. Chen, G. Li, E. Zhao, J.V. Jokerst

Nanotoxicity predictive modeling: A case study on metal oxides nanoparticles. B. Rasulev

Surface-modified gold nanoparticles and their long-term impact on cellular pathways. P. Falagan Lotsch, E. Grzincic, C.J. Murphy

WEDNESDAY MORNING

Nanomaterials in Drug Delivery: Efficacy & Toxicity Considerations

Cosponsored by MEDI
P. F. Guengerich, W. G. Humphreys, N. A. Meanwell, Organizers, Presiding

8:00Introductory Remarks.

8:05. What exactly is toxic about colloidal nanoparticle formulations? Results from the molecular level and the cellular level. C.J. Murphy

8:45. Targeting or Enhanced Selectivity: Toxicological considerations of nanoparticle therapeutics. R. Darvari

9:25. Expansile nanoparticles for the treatment of intraperitoneal mesothelioma. M.W. Grinstaff

10:05 Intermission.

10:20. Debugging nano–bio interfaces. M. Mahmoudi

11:00. Understanding mast cell activation in the safe development of nanotechnologies. J. Brown

WEDNESDAY AFTERNOON

Topics in Chemical Toxicology

P. Beuning, Organizer
T. Spratt, Organizer, Presiding

1:00. Base and nucleotide excision repair of site-specific oxidatively generated guanine lesions in DNA substrates transfected into human cells. V. Shafirovich, K. Kropachev, M. Kolbanovskiy, N.E. Geacintov

1:20. Reduction pathway-dependent cytotoxicity of reduced graphene oxide. C. Zhang, Q. Zhang

1:40 . Site-Specific Production of Hydroxyl Radicals and Synergistic DNA Damage Induced by the Non-Enzymatic Activation of the Anti-Tuberculosis Drug Isoniazid by Cu(II). B. Zhu

2:00. Insights into the molecular mechanism of alkylation- and platination-induced mutagenesis. S. Lee, Y. Kou

2:20. Kinetic Basis of DNA Synthesis by Human DNA Polymerase/Primase PrimPol. L. Zhao

2:40 Intermission.

3:00. Levels of glyoxal-induced hemoglobin modifications correlate with DNA cross-links in human blood as determined by mass spectrometry. H.C. Chen, C. Liu

3:20. High mobility group box 1: a re-evaluation of its role in cancer. I.A. Blair, L. Weng, L. Guo, A. Vachani, C. Mesaros

3:40. Determining Associations between Transcriptomics and Toxicity using Co-Expression Network Methods. B. Alexander-Dann, T. James, A. Bender

4:00. Inhibitors of the mitochondrial respiratory complex – Structure-based prediction of toxicity. G.F. Ecker, F. Troger, S. Jain, B. Zdrazil

4:20. Configurational and Conformational Equilibria of the N6-(2-Deoxy-D-erythro- pentofuranoysl-)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine (MeFapy- dG) Lesion in DNA. M.P. Stone, S.N. Bamberger, C.K. Malik, T.L. Johnson-Salyard, S.K. Brown, H. Pan, C.J. Rizzo, M.W. Voehler

4:40 . Using open bioactivity data for developing machine-learning prediction models for chemical modulators of the retinoid X receptor (RXR) signaling pathway. S. Kim

Contact Thomas Spratt if you would like to add another event to this page