262nd ACS Fall 2021 • Resilience Of Chemistry


22 Aug 2021  -  26 Aug 2021

At Online and In-Person

Sunday

CRT Young Investigator Award: CRT Young Investigator Award

08:00am – 09:55am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Shana Sturla, Organizer; Shana Sturla, Presider; Christie Sayes, Presider, RTI International

Introductory Remarks

08:00am – 08:05am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Vaping chemistry and the environment

08:05am – 08:30am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Robert Strongin, Presenter

Understanding how environmental factors influence the impact of emerging contaminants

08:30am – 08:55am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Sherine Obare, Presenter, Univ. of North Carolina, Greensboro

Intermission

08:55am – 09:05am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Combination of a quantitative toxicity assessment tool and targeted disinfection byproduct screening for drinking water mixture quality evaluation and toxicity driver identification

09:05am – 09:30am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Jingyi Wu, Presenter; Joshua Allen; Susan Richardson, University of South Carolina; Michael Plewa; Stuart Krasner; Akram Alshawabkeh; April Gu

Differential cytotoxicity of drinking water contaminant co-exposures against human intestinal and neuronal cells

09:30am – 09:55am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Christie Sayes, Presenter, RTI International; Jiaqi Liu, Baylor University; Sahar Pradhan

 


TOXI Founders Award Symposium:

10:30am – 12:25pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

John Essigmann, Organizer, MIT; Stephen Hecht, Organizer; John Essigmann, Presider, MIT

DNA protein crosslinks: DNA lesions or epigenetic regulators?

10:30am – 10:53am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Natalia Tretyakova, Presenter, University of Minnesota; Jenna Thomforde; Shaofei Ji; Iwen Fu; Ashis Basu; Suse Broyde

Chemical biology of DNA damage and repair

10:53am – 11:16am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Dr. Deyu Li, Presenter

Overcoming the packaging paradox: DNA base excision repair in chromatin

11:16am – 11:39am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Sarah Delaney, Presenter, Brown University

Chemically induced DNA damage and mutagenesis: Genome-wide patterns and sequence-specific localization

11:39am – 12:02pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Shana Sturla, Presenter

Mutational spectra provide insight into the mechanisms bridging DNA damage to genetic disease

12:02pm – 12:25pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

John Essigmann, Presenter, MIT; Robert Croy; Bogdan Fedeles


TOXI Keynote Lecture:

02:00pm – 02:50pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Patrick Breysse, Organizer; Natalia Tretyakova, Organizer, University of Minnesota; Natalia Tretyakova, Presider, University of Minnesota

Introductory Remarks

02:00pm – 02:05pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Biological monitoring and public health

02:05pm – 02:50pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Patrick Breysse, Presenter


 

Toxicants & Cellular Aging:

04:30pm – 06:30pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Laura Niedernhofer, Organizer; Michael Trakselis, Organizer, Baylor University; Michael Trakselis, Presider, Baylor University; Laura Niedernhofer, Presider

The DNA recombination helicase, MCM8/9, stabilizes stalled forks

04:30pm – 04:53pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Michael Trakselis, Presenter, Baylor University

DNA structure induced mutation hotspots in cancer and aging

04:53pm – 05:16pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Guliang Wang; Alexandra D’Amico; Tonia Li; Karen Vasquez, Presenter

Using chemoptogenetics to study cellular responses to telomere specific 8-oxoguanine damage

05:16pm – 05:39pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Patricia Opresko, Presenter; Ryan Barnes; Mariarosaria De Rosa; Marcel Bruchez

Intermission

05:39pm – 05:44pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Regulation of aging through chromatin-regulated stress response pathways

05:44pm – 06:07pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Weiwei Dang, Presenter

Cellular senescence as a driver of aging and age-related diseases

06:07pm – 06:30pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314

Laura Niedernhofer, Presenter


General Posters:

07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL

Erin Prestwich, Organizer, University of Toledo; Ujjal Sarkar, Organizer, MIT; Grover Miller, Organizer, Dept of Biochem and Mol Biol

Endogenous versus exogenous sources of monohydroxy-3-butenyl and dihydroxybutyl mercapturic acid metabolites and N7-(1-hydroxy-3-buten-2-yl) guanine DNA adducts

07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL

Caitlin Jokipii Krueger, Presenter; Erik Moran; Natalia Tretyakova, University of Minnesota

Toxicity focused product development offers time, effort, and money savings; defines greener processes

07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL

Neelam Vaidya, Presenter, ViridisChem, Inc.

pH effects on oxidative modification of alkylative DNA adducts by the AlkB-family enzymes

07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL

Samuel Howarth, Presenter; Vincent Falkowski; Xin Bush; Rui Qi; Dr. Deyu Li

Sequence context effects of replication of Fapy-dG in three mutational hot spot sequences of the p53 gene in human cells

07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL

Jan Henric Bacurio, Presenter; Spandana Naldiga; Brent Powell; Haozhe Yang; Marc Greenberg; Ashis Basu

Assessment of occupational exposure of firefighters to mono and polyaromatic hydrocarbons using intrinsic fluorescence

07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL

Marcela Jaramillo, Presenter

Characterization of phenotypic and DNA modifications of Pseudomonas aeruginosa wild-type and genomic variant strains

07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL

Eric Carlson, Presenter; Taylor Dodson; Chase Morse; Nathan Wamer; Erin Prestwich, University of Toledo


Monday

Student & Post-Doctoral Scholar Symposium: Student & Post-Doctoral Scholar Symposium

08:00am – 10:00am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Erin Prestwich, Organizer, University of Toledo; Ujjal Sarkar, Organizer, MIT; Ujjal Sarkar, Presider, MIT; Erin Prestwich, Presider, University of Toledo

Ribonucleotide containing DNA facilitates the identification of cross-linked amino acid residues in DNA protein cross links

08:00am – 08:15am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Jin Tang, Presenter; Wenxin Zhao; Linlin Zhao, University of California, Riverside

Experimental study of Lumbricus teresstris to arsenic bioaccumulation

08:15am – 08:30am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Hira Khan, Presenter; Nazia Ehsan; Nabeel Khan Niazi

Removal of common alterations in genomic DNA for accurate damage sequencing

08:30am – 08:45am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Nikolai Püllen, Presenter, ETHZ; Hailey Gahlon; Shana Sturla

Influence of food on the in vivo bioavailability of DDT and its metabolites in soils

08:45am – 09:00am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Yi Chen, Presenter; Ruichen Zheng; Xinyi Cui

Fishing for damage: Recognition and repair of OG:A mispairs by MutY

09:00am – 09:15am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Merve Demir, Presenter; Peyton Russelburg; Valerie O’Shea Murray; Sheila David, Univ of California; Martin Horvath

Methylglyoxal derived post-translational modifications restore metabolic homeostasis in diet-induced metabolic disorder

09:15am – 09:30am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Dominique Gaffney, Presenter; Erin Jennings; Marissa Trujillo; Micaela Roy; Julie Reisz; Diego Perez-Gamboa; Emely Hoffman; David Orlicky; James Wepy; Brenda Crews; Angelo D’Alessandro; Lawrence Marnett; James Galligan

Analysis of post-transcriptional modifications in tRNAs associated with hyperglycemia in diabetes-associated cells

09:30am – 09:45am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Taylor Dodson, Presenter; Chao Liu; Samuel Senyo; Erin Prestwich, University of Toledo

Uncovering the landscape of phosphorothioates in the human gut microbiome

09:45am – 10:00am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Dr. Shane Byrne, Presenter; Yifeng Yuan; Michael DeMott; Stefanie Kellner; Bo Cao; Eric Alm; Peter Dedon

 


TOXI at 25: Chemical Toxicology Division Anniversary Symposium:

10:30am – 12:30pm USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Sarah Shuck, Organizer, City of Hope; Michael Trakselis, Organizer, Baylor University; Michael Trakselis, Presider, Baylor University; Sarah Shuck, Presider, City of Hope

Introductory Remarks

10:30am – 10:35am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Sixteen years of catching DNA polymerases in the act of mistakes: What have we learned about DNA adducts?

10:35am – 10:53am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

F Guengerich, Presenter; Martin Egli

Impact of structurally distinct DNA lesions on the unwinding of double-stranded DNA by helicases

10:53am – 11:11am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Ana Sales; Vladimir Shafirovich; Alexander Durandin; Hong Mu; Suse Broyde; Nicholas Geacintov, Presenter

The role of pyridyloxobutyl DNA adducts in the carcinogenic properties of tobacco-specific nitrosamines

11:11am – 11:29am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Lisa Peterson, Presenter

Intermission

11:29am – 11:34am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Recent studies on phenanthrene and acrolein biomarkers in cigarette smokers and non-smokers

11:34am – 11:52am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Stephen Hecht, Presenter; Kai Luo; Steven Carmella; Silvia Balbo; Viviana Paiano; Dorothy Hatsukami

Chemical toxicology of human gut microbiota

11:52am – 12:10pm USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Shana Sturla, Presenter

Adventures of a chemist in toxicology: DNA adducts, epigenetic deregulation, and proteins trapped on DNA strands

12:10pm – 12:28pm USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214

Natalia Tretyakova, Presenter, University of Minnesota

 


Thinking Outside the Well: Novel Assays in Drug Discovery & Development:

02:00pm – 03:50pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49

Donna Huryn, Organizer, University of Pittsburgh; Michael Walters, Organizer, The University of Minnesota; Donna Huryn, Presider, University of Pittsburgh; Michael Walters, Presider, The University of Minnesota

Introductory Remarks

02:00pm – 02:05pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49

Scaling up: Zebrafish behaviors as scalable phenotypes for small molecule screening

02:05pm – 02:25pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49

Yijie Geng; Randall Peterson, Presenter

Zebrafish assays to drive medicinal chemistry: Challenges and opportunities

02:25pm – 02:45pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49

Donna Huryn, Presenter, University of Pittsburgh

Go with the flow and reduce animal testing: Application of microphysiological system (MPS) technology using liver-on-chips to genotoxicity testing

02:45pm – 03:05pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49

Dr Thalita Boldrin Zanoni, Presenter; Ammer Khawam; Karen DiPerna; Annie Hamel

Complex (not complicated) in vitro scale-able models for phenotypic drug screening

03:05pm – 03:25pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49

Banupriya Sridharan, Presenter; Jason Ekert

Drug screening using 3D Biofabricated tissues

03:25pm – 03:45pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49

Marc Ferrer, Presenter

Concluding Remarks

03:45pm – 03:50pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49

 


Tuesday

General Posters:

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Erin Prestwich, Organizer, University of Toledo; Ujjal Sarkar, Organizer, MIT; Grover Miller, Organizer, Dept of Biochem and Mol Biol

Amyotrophic lateral sclerosis (ALS): What do we really know about the role of the environment?

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Melanie Newell, Presenter; Sangeet Adhikari; Rolf Halden

Docking study on the position of nitro groups affecting the mutagenicity of nitroarenes

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Akiko Ohno, Presenter; Yoshio Okiyama; Akihiko Hirose; Kiyoshi Fukuhara

C-Methylated fisetins with strong antioxidative activities

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Kiyoshi Fukuhara, Presenter; Akiko Ohno

Withania somnifera metabolites withanone, withaferin A, and their GSH conjugates are potential irreversible inhibitors of the SARS-CoV-2 protease Mpro

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Shayantani Chakraborty, Presenter; Dibyendu Mallick; Mausumi Goswami; Anindita Chakrabarty; Goutam Chowdhury

Monitoring the formation and repair kinetics of cisplatin-induced DNA-DNA cross-links by comprehensive ultra-performance liquid chromatograph-selective ion monitoring (UPLC-SIM)

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Arnold Groehler, Presenter; Anuar Makhmut; Nhat Mai Dao; Orlando Schärer

Role of Aldo-Keto reductases in the nitroreduction of 1-nitropyrene and 1,8-dinitropyrene

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Anthony Su, Presenter; Trevor Penning

Mechanism of DNA damage by the anticancer agent sepantronium bromide (YM155)

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Shaista Haider, Presenter; Anindita Chakrabarty; Goutam Chowdhury

DNA adducts as molecular markers of aging

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Dr. Guilbaud Axel, Presenter; Jiapeng Leng; Jacqueline Gamboa-Wilson; Monica Cassandras; Fang Cao; Elisabeth Ricci-Blair; Ken Bedi; Kenneth Margulies; Richard Lee; Peter Dedon

Biosynthesis of acrolein with a coupled enzyme system to emulate continuous acrolein production by gut microbiota

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Katherine Hurley, Presenter; Jasmin Zgraggen; Tania Cruz; Sabine Diedrich; Xuan Li; Shana Sturla

Presence of heavy metals in soil and health risk assessment around the e-waste dumping site

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Deblina Dutta, Presenter; Sudha Goel; Sunil Kumar

Determining the effects of adulterants on metabolite found in Adderall

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Cameron Bordi, Presenter

Beyond the lesion: The switch back to high fidelity synthesis

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Joseph Kaszubowski, Presenter; Michael Trakselis, Baylor University

Structural modeling of MIE interactions – docking neonicotinoids into human nAChR

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Karin Grillberger, Presenter; Dominik Loser; Jonathan Blum; Marcel Leist; Gerhard Ecker, Presenter

The DNA adductome portal: A one-stop search site for DNA adduct Information

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Jingshu Guo, Presenter; Scott Walmsley; Peter Villalta; Anamary Tarifa; Anthony De Caprio; Marcus Cooke; Robert Turesky

Analysis of interactions of human polymerase kappa and DinB polymerases with damaged DNA

12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4

Mansi Kinare, Presenter; Lakindu Pathira Kankanamge; Penny Beuning, Presenter; Dr. Mary Jo Ondrechen, Northeastern University


Topics in Chemical Toxicology:

02:00pm – 03:50pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45

Sarah Shuck, Organizer, City of Hope; Linlin Zhao, Organizer, University of California, Riverside; Sarah Shuck, Presider, City of Hope; Linlin Zhao, Presider, University of California, Riverside

Conjugation of the synthetic anthracycline chemotherapeutic pixantrone with an apurinic site in DNA

02:00pm – 02:10pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45

Andrew Kellum, Presenter; Pradeep Pallan; Yizhi Fu; John Terrell; Brian Noh; Markus Voehler; Carmello Rizzo; Martin Egli; Michael Stone, Presenter

Cleavage of abasic DNA by mitochondrial transcription factor A

02:10pm – 02:20pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45

Wenyan Xu; Jin Tang; Ching-Hsin Yang; Wenxin Zhao; Linlin Zhao, Presenter, University of California, Riverside

Cytotoxicity and genotoxicity of tobacco smoke in human bladder epithelial cells

02:20pm – 02:30pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45

Medjda Bellamri, Presenter; Christina Brown; Kyle Brandt; Chia-Fang Wu; Ming-Tsang Wu; Robert Turesky

Exploring the interactome of translesion DNA synthesis polymerase kappa

02:30pm – 02:40pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45

Shilpi Paul, Presenter; Paolo Cifani; Darryl Pappin; Thomas Spratt

Your body’s response to stress: The enzymatic oxidation of deoxycorticosterone by cytochrome P450 CYP11B2

02:40pm – 02:50pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45

Kari Knobbe, Presenter; Joseph Schell; Rainer Glaser

Introductory Remarks

02:50pm – 03:00pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45

Evaluating quantitative and qualitative methodologies for detection of fentanyl and fentanyl-related analogues in urine samples using LCMSMS and LC-QTOF respectively

03:00pm – 03:10pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45

Unaiza Uzair, Presenter; Lamvien Nguyen; Alyson Edwards; James LaPalme; Elizabeth Bair; Nicolas Epie

 

Untargeted proteomics reveals the potential synergistic effects of PFAA mixtures on the plasma proteome of rainbow trout with PPARβ/δ activation and developmental neurotoxicity as avenues of interest

03:10pm – 03:20pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45

Mr. Simon Pollard, Presenter, Ontario Tech University; Vlastimil Packa; Vasile Furdui; Denina Simmons

Developing GFAAS- and ICP-OES-based methodologies for studying the toxicity and interactions of silver nanoparticles with human red blood cells

03:20pm – 03:30pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45

Samuel Herndon, Presenter; Praveen Kumar Alla; Kelsey Hood; Norma Adragna; Ioana Pavel

The adsorption and removal of actinides from human teeth

03:30pm – 03:40pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45

Jafar Ali, Presenter; Artem Duda; Tanja Tane; Dihara Hossain; Jasmine Wang; Samuel Groveman; Jacopo Samson; Spiro Alexandratos; Ali Younes

Combining CytoViva and Raman hyperspectral imaging to study the uptake, distribution, and toxicity of silver nanoparticles in human red blood cells

03:40pm – 03:50pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45

Praveen Kumar Alla, Presenter; Samuel Herndon; Kelsey Hood; Ioana Pavel; Norma Adragna

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