22 Aug 2021 - 26 Aug 2021
At Online and In-Person
https://www.acs.org/content/acs/en/meetings/acs-meetings.html
Sunday
CRT Young Investigator Award: CRT Young Investigator Award
08:00am – 09:55am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Shana Sturla, Organizer; Shana Sturla, Presider; Christie Sayes, Presider, RTI International
Introductory Remarks
08:00am – 08:05am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Vaping chemistry and the environment
08:05am – 08:30am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Robert Strongin, Presenter
Understanding how environmental factors influence the impact of emerging contaminants
08:30am – 08:55am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Sherine Obare, Presenter, Univ. of North Carolina, Greensboro
Intermission
08:55am – 09:05am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Combination of a quantitative toxicity assessment tool and targeted disinfection byproduct screening for drinking water mixture quality evaluation and toxicity driver identification
09:05am – 09:30am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Jingyi Wu, Presenter; Joshua Allen; Susan Richardson, University of South Carolina; Michael Plewa; Stuart Krasner; Akram Alshawabkeh; April Gu
Differential cytotoxicity of drinking water contaminant co-exposures against human intestinal and neuronal cells
09:30am – 09:55am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Christie Sayes, Presenter, RTI International; Jiaqi Liu, Baylor University; Sahar Pradhan
TOXI Founders Award Symposium:
10:30am – 12:25pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
John Essigmann, Organizer, MIT; Stephen Hecht, Organizer; John Essigmann, Presider, MIT
DNA protein crosslinks: DNA lesions or epigenetic regulators?
10:30am – 10:53am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Natalia Tretyakova, Presenter, University of Minnesota; Jenna Thomforde; Shaofei Ji; Iwen Fu; Ashis Basu; Suse Broyde
Chemical biology of DNA damage and repair
10:53am – 11:16am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Dr. Deyu Li, Presenter
Overcoming the packaging paradox: DNA base excision repair in chromatin
11:16am – 11:39am USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Sarah Delaney, Presenter, Brown University
Chemically induced DNA damage and mutagenesis: Genome-wide patterns and sequence-specific localization
11:39am – 12:02pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Shana Sturla, Presenter
Mutational spectra provide insight into the mechanisms bridging DNA damage to genetic disease
12:02pm – 12:25pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
John Essigmann, Presenter, MIT; Robert Croy; Bogdan Fedeles
TOXI Keynote Lecture:
02:00pm – 02:50pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Patrick Breysse, Organizer; Natalia Tretyakova, Organizer, University of Minnesota; Natalia Tretyakova, Presider, University of Minnesota
Introductory Remarks
02:00pm – 02:05pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Biological monitoring and public health
02:05pm – 02:50pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Patrick Breysse, Presenter
Toxicants & Cellular Aging:
04:30pm – 06:30pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Laura Niedernhofer, Organizer; Michael Trakselis, Organizer, Baylor University; Michael Trakselis, Presider, Baylor University; Laura Niedernhofer, Presider
The DNA recombination helicase, MCM8/9, stabilizes stalled forks
04:30pm – 04:53pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Michael Trakselis, Presenter, Baylor University
DNA structure induced mutation hotspots in cancer and aging
04:53pm – 05:16pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Guliang Wang; Alexandra D’Amico; Tonia Li; Karen Vasquez, Presenter
Using chemoptogenetics to study cellular responses to telomere specific 8-oxoguanine damage
05:16pm – 05:39pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Patricia Opresko, Presenter; Ryan Barnes; Mariarosaria De Rosa; Marcel Bruchez
05:39pm – 05:44pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Regulation of aging through chromatin-regulated stress response pathways
05:44pm – 06:07pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Weiwei Dang, Presenter
Cellular senescence as a driver of aging and age-related diseases
06:07pm – 06:30pm USA / Canada – Eastern – August 22, 2021 | Room: B313b – B314
Laura Niedernhofer, Presenter
General Posters:
07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL
Erin Prestwich, Organizer, University of Toledo; Ujjal Sarkar, Organizer, MIT; Grover Miller, Organizer, Dept of Biochem and Mol Biol
Endogenous versus exogenous sources of monohydroxy-3-butenyl and dihydroxybutyl mercapturic acid metabolites and N7-(1-hydroxy-3-buten-2-yl) guanine DNA adducts
07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL
Caitlin Jokipii Krueger, Presenter; Erik Moran; Natalia Tretyakova, University of Minnesota
Toxicity focused product development offers time, effort, and money savings; defines greener processes
07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL
Neelam Vaidya, Presenter, ViridisChem, Inc.
pH effects on oxidative modification of alkylative DNA adducts by the AlkB-family enzymes
07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL
Samuel Howarth, Presenter; Vincent Falkowski; Xin Bush; Rui Qi; Dr. Deyu Li
Sequence context effects of replication of Fapy-dG in three mutational hot spot sequences of the p53 gene in human cells
07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL
Jan Henric Bacurio, Presenter; Spandana Naldiga; Brent Powell; Haozhe Yang; Marc Greenberg; Ashis Basu
Assessment of occupational exposure of firefighters to mono and polyaromatic hydrocarbons using intrinsic fluorescence
07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL
Marcela Jaramillo, Presenter
Characterization of phenotypic and DNA modifications of Pseudomonas aeruginosa wild-type and genomic variant strains
07:00pm – 09:00pm USA / Canada – Eastern – August 22, 2021 | Room: B2 – EXHIBIT HALL
Eric Carlson, Presenter; Taylor Dodson; Chase Morse; Nathan Wamer; Erin Prestwich, University of Toledo
Monday
Student & Post-Doctoral Scholar Symposium: Student & Post-Doctoral Scholar Symposium
08:00am – 10:00am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Erin Prestwich, Organizer, University of Toledo; Ujjal Sarkar, Organizer, MIT; Ujjal Sarkar, Presider, MIT; Erin Prestwich, Presider, University of Toledo
Ribonucleotide containing DNA facilitates the identification of cross-linked amino acid residues in DNA protein cross links
08:00am – 08:15am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Jin Tang, Presenter; Wenxin Zhao; Linlin Zhao, University of California, Riverside
Experimental study of Lumbricus teresstris to arsenic bioaccumulation
08:15am – 08:30am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Hira Khan, Presenter; Nazia Ehsan; Nabeel Khan Niazi
Removal of common alterations in genomic DNA for accurate damage sequencing
08:30am – 08:45am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Nikolai Püllen, Presenter, ETHZ; Hailey Gahlon; Shana Sturla
Influence of food on the in vivo bioavailability of DDT and its metabolites in soils
08:45am – 09:00am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Yi Chen, Presenter; Ruichen Zheng; Xinyi Cui
Fishing for damage: Recognition and repair of OG:A mispairs by MutY
09:00am – 09:15am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Merve Demir, Presenter; Peyton Russelburg; Valerie O’Shea Murray; Sheila David, Univ of California; Martin Horvath
Methylglyoxal derived post-translational modifications restore metabolic homeostasis in diet-induced metabolic disorder
09:15am – 09:30am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Dominique Gaffney, Presenter; Erin Jennings; Marissa Trujillo; Micaela Roy; Julie Reisz; Diego Perez-Gamboa; Emely Hoffman; David Orlicky; James Wepy; Brenda Crews; Angelo D’Alessandro; Lawrence Marnett; James Galligan
Analysis of post-transcriptional modifications in tRNAs associated with hyperglycemia in diabetes-associated cells
09:30am – 09:45am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Taylor Dodson, Presenter; Chao Liu; Samuel Senyo; Erin Prestwich, University of Toledo
Uncovering the landscape of phosphorothioates in the human gut microbiome
09:45am – 10:00am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Dr. Shane Byrne, Presenter; Yifeng Yuan; Michael DeMott; Stefanie Kellner; Bo Cao; Eric Alm; Peter Dedon
TOXI at 25: Chemical Toxicology Division Anniversary Symposium:
10:30am – 12:30pm USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Sarah Shuck, Organizer, City of Hope; Michael Trakselis, Organizer, Baylor University; Michael Trakselis, Presider, Baylor University; Sarah Shuck, Presider, City of Hope
Introductory Remarks
10:30am – 10:35am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Sixteen years of catching DNA polymerases in the act of mistakes: What have we learned about DNA adducts?
10:35am – 10:53am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
F Guengerich, Presenter; Martin Egli
Impact of structurally distinct DNA lesions on the unwinding of double-stranded DNA by helicases
10:53am – 11:11am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Ana Sales; Vladimir Shafirovich; Alexander Durandin; Hong Mu; Suse Broyde; Nicholas Geacintov, Presenter
The role of pyridyloxobutyl DNA adducts in the carcinogenic properties of tobacco-specific nitrosamines
11:11am – 11:29am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Lisa Peterson, Presenter
Intermission
11:29am – 11:34am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Recent studies on phenanthrene and acrolein biomarkers in cigarette smokers and non-smokers
11:34am – 11:52am USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Stephen Hecht, Presenter; Kai Luo; Steven Carmella; Silvia Balbo; Viviana Paiano; Dorothy Hatsukami
Chemical toxicology of human gut microbiota
11:52am – 12:10pm USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Shana Sturla, Presenter
Adventures of a chemist in toxicology: DNA adducts, epigenetic deregulation, and proteins trapped on DNA strands
12:10pm – 12:28pm USA / Canada – Eastern – August 23, 2021 | Room: B213 – B214
Natalia Tretyakova, Presenter, University of Minnesota
Thinking Outside the Well: Novel Assays in Drug Discovery & Development:
02:00pm – 03:50pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49
Donna Huryn, Organizer, University of Pittsburgh; Michael Walters, Organizer, The University of Minnesota; Donna Huryn, Presider, University of Pittsburgh; Michael Walters, Presider, The University of Minnesota
Introductory Remarks
02:00pm – 02:05pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49
Scaling up: Zebrafish behaviors as scalable phenotypes for small molecule screening
02:05pm – 02:25pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49
Yijie Geng; Randall Peterson, Presenter
Zebrafish assays to drive medicinal chemistry: Challenges and opportunities
02:25pm – 02:45pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49
Donna Huryn, Presenter, University of Pittsburgh
Go with the flow and reduce animal testing: Application of microphysiological system (MPS) technology using liver-on-chips to genotoxicity testing
02:45pm – 03:05pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49
Dr Thalita Boldrin Zanoni, Presenter; Ammer Khawam; Karen DiPerna; Annie Hamel
Complex (not complicated) in vitro scale-able models for phenotypic drug screening
03:05pm – 03:25pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49
Banupriya Sridharan, Presenter; Jason Ekert
Drug screening using 3D Biofabricated tissues
03:25pm – 03:45pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49
Marc Ferrer, Presenter
Concluding Remarks
03:45pm – 03:50pm USA / Canada – Eastern – August 23, 2021 | Room: Zoom Room 49
Tuesday
General Posters:
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Erin Prestwich, Organizer, University of Toledo; Ujjal Sarkar, Organizer, MIT; Grover Miller, Organizer, Dept of Biochem and Mol Biol
Amyotrophic lateral sclerosis (ALS): What do we really know about the role of the environment?
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Melanie Newell, Presenter; Sangeet Adhikari; Rolf Halden
Docking study on the position of nitro groups affecting the mutagenicity of nitroarenes
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Akiko Ohno, Presenter; Yoshio Okiyama; Akihiko Hirose; Kiyoshi Fukuhara
C-Methylated fisetins with strong antioxidative activities
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Kiyoshi Fukuhara, Presenter; Akiko Ohno
Withania somnifera metabolites withanone, withaferin A, and their GSH conjugates are potential irreversible inhibitors of the SARS-CoV-2 protease Mpro
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Shayantani Chakraborty, Presenter; Dibyendu Mallick; Mausumi Goswami; Anindita Chakrabarty; Goutam Chowdhury
Monitoring the formation and repair kinetics of cisplatin-induced DNA-DNA cross-links by comprehensive ultra-performance liquid chromatograph-selective ion monitoring (UPLC-SIM)
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Arnold Groehler, Presenter; Anuar Makhmut; Nhat Mai Dao; Orlando Schärer
Role of Aldo-Keto reductases in the nitroreduction of 1-nitropyrene and 1,8-dinitropyrene
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Anthony Su, Presenter; Trevor Penning
Mechanism of DNA damage by the anticancer agent sepantronium bromide (YM155)
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Shaista Haider, Presenter; Anindita Chakrabarty; Goutam Chowdhury
DNA adducts as molecular markers of aging
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Dr. Guilbaud Axel, Presenter; Jiapeng Leng; Jacqueline Gamboa-Wilson; Monica Cassandras; Fang Cao; Elisabeth Ricci-Blair; Ken Bedi; Kenneth Margulies; Richard Lee; Peter Dedon
Biosynthesis of acrolein with a coupled enzyme system to emulate continuous acrolein production by gut microbiota
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Katherine Hurley, Presenter; Jasmin Zgraggen; Tania Cruz; Sabine Diedrich; Xuan Li; Shana Sturla
Presence of heavy metals in soil and health risk assessment around the e-waste dumping site
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Deblina Dutta, Presenter; Sudha Goel; Sunil Kumar
Determining the effects of adulterants on metabolite found in Adderall
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Cameron Bordi, Presenter
Beyond the lesion: The switch back to high fidelity synthesis
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Joseph Kaszubowski, Presenter; Michael Trakselis, Baylor University
Structural modeling of MIE interactions – docking neonicotinoids into human nAChR
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Karin Grillberger, Presenter; Dominik Loser; Jonathan Blum; Marcel Leist; Gerhard Ecker, Presenter
The DNA adductome portal: A one-stop search site for DNA adduct Information
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Jingshu Guo, Presenter; Scott Walmsley; Peter Villalta; Anamary Tarifa; Anthony De Caprio; Marcus Cooke; Robert Turesky
Analysis of interactions of human polymerase kappa and DinB polymerases with damaged DNA
12:30pm – 02:00pm USA / Canada – Eastern – August 24, 2021 | Room: Row 4
Mansi Kinare, Presenter; Lakindu Pathira Kankanamge; Penny Beuning, Presenter; Dr. Mary Jo Ondrechen, Northeastern University
Topics in Chemical Toxicology:
02:00pm – 03:50pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45
Sarah Shuck, Organizer, City of Hope; Linlin Zhao, Organizer, University of California, Riverside; Sarah Shuck, Presider, City of Hope; Linlin Zhao, Presider, University of California, Riverside
Conjugation of the synthetic anthracycline chemotherapeutic pixantrone with an apurinic site in DNA
02:00pm – 02:10pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45
Andrew Kellum, Presenter; Pradeep Pallan; Yizhi Fu; John Terrell; Brian Noh; Markus Voehler; Carmello Rizzo; Martin Egli; Michael Stone, Presenter
Cleavage of abasic DNA by mitochondrial transcription factor A
02:10pm – 02:20pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45
Wenyan Xu; Jin Tang; Ching-Hsin Yang; Wenxin Zhao; Linlin Zhao, Presenter, University of California, Riverside
Cytotoxicity and genotoxicity of tobacco smoke in human bladder epithelial cells
02:20pm – 02:30pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45
Medjda Bellamri, Presenter; Christina Brown; Kyle Brandt; Chia-Fang Wu; Ming-Tsang Wu; Robert Turesky
Exploring the interactome of translesion DNA synthesis polymerase kappa
02:30pm – 02:40pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45
Shilpi Paul, Presenter; Paolo Cifani; Darryl Pappin; Thomas Spratt
Your body’s response to stress: The enzymatic oxidation of deoxycorticosterone by cytochrome P450 CYP11B2
02:40pm – 02:50pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45
Kari Knobbe, Presenter; Joseph Schell; Rainer Glaser
02:50pm – 03:00pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45
Evaluating quantitative and qualitative methodologies for detection of fentanyl and fentanyl-related analogues in urine samples using LCMSMS and LC-QTOF respectively
03:00pm – 03:10pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45
Unaiza Uzair, Presenter; Lamvien Nguyen; Alyson Edwards; James LaPalme; Elizabeth Bair; Nicolas Epie
Untargeted proteomics reveals the potential synergistic effects of PFAA mixtures on the plasma proteome of rainbow trout with PPARβ/δ activation and developmental neurotoxicity as avenues of interest
03:10pm – 03:20pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45
Mr. Simon Pollard, Presenter, Ontario Tech University; Vlastimil Packa; Vasile Furdui; Denina Simmons
Developing GFAAS- and ICP-OES-based methodologies for studying the toxicity and interactions of silver nanoparticles with human red blood cells
03:20pm – 03:30pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45
Samuel Herndon, Presenter; Praveen Kumar Alla; Kelsey Hood; Norma Adragna; Ioana Pavel
The adsorption and removal of actinides from human teeth
03:30pm – 03:40pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45
Jafar Ali, Presenter; Artem Duda; Tanja Tane; Dihara Hossain; Jasmine Wang; Samuel Groveman; Jacopo Samson; Spiro Alexandratos; Ali Younes
Combining CytoViva and Raman hyperspectral imaging to study the uptake, distribution, and toxicity of silver nanoparticles in human red blood cells
03:40pm – 03:50pm USA / Canada – Eastern – August 24, 2021 | Room: Zoom Room 45
Praveen Kumar Alla, Presenter; Samuel Herndon; Kelsey Hood; Ioana Pavel; Norma Adragna