Sunday Aug 16, 2020
TOXI Young Investigators Symposium
Organizers: Erin Prestwich and Ujjal Sarkar
TOXI 1. 8:05 AM. Geisen, Susanne. Chemical mechanism of O6-carboxymethyldeoxyguanine formation from azaserine and abundance in cells [Abstract]
TOXI 2. 8:25 AM. Li, Yupeng. Investigation of 2′-Deoxyadenosine-derived adducts specifically formed in rat liver by N’-nitrosonornicotine (NNN) metabolism [Abstract]
TOXI 3. 8:45 AM. Terrell, John. Covalent binding of anthracyclines to AP sites in DNA suggest an unstudied mechanism of cytotoxicity from chemotherapeutic regimens [Abstract]
TOXI 4. 9:05 AM. Ahmed, C. M. Sabbir. Integrative analysis of lncRNA-mRNA co-expression in human lung epithelial cells exposed to dimethyl selenide (DMSe)-derived secondary organic aerosols [Abstract]
TOXI 5. 9:25 AM. Li, Miao. Development of the generic pregnancy physiologically based pharmacokinetic (PBPK) model to support regulatory evaluations of the safety and efficacy of therapeutic agents [Abstract]
TOXI 6. 10:05 AM. Demir, Merve. Fishing for OG lesions: Structural and biochemical insights into OG detection by MutY [Abstract]
TOXI 7. 10:25 AM. Hurley, Katherine. Biosynthesis of acrolein with a coupled enzyme system to emulate continuous acrolein production by gut microbiota [Abstract]
TOXI 8. 10:45 AM. Pujari, Suresh. Synthesis, structural confirmation, and detection of EB-FAPy-dG and DEB-FAPy-dG adducts in human cells [Abstract]
TOXI 9. 11:05 AM. Cranford, Matthew. Locating the second polymerase switch: Where resumption of replication limits the length of translesion synthesis [Abstract]
TOXI 10. 11:25 AM. Wu, Junzhou. Derivatization of Phosphorothioate DNA modifications by direct chemical conjugation [Abstract]
Sunday Aug 16, 2020
Founders Award
Organizers: Pete Dedon
TOXI 11. 1:35 PM. Jaffrey, Samie. Chemical methods for detecting and quantifying nucleotide modifications in mRNA [Abstract]
TOXI 12. 2:15 PM. Begley, Thomas. Epitranscriptomic marks translationally regulate stress response programs to protect against environmental insults [Abstract]
TOXI 13. 3:15 PM. Gregory, Richard. Role of the Epitranscriptome in gene regulation and cancer [Abstract]
TOXI 14. 4:00 PM. Dedon, Peter. Old becomes new in the epi-verse of DNA and RNA modifications [Abstract]
Monday Aug 17, 2020
Toxicology of Antibody-Drug Conjugates
Organizers: Sanjeev Gangwar and Michael Trakselis
TOXI 15. 8:00 AM. Bertozzi, Carolyn. Multifunctional biologics for extracellular targeted degradation [Abstract]
TOXI 16. 8:40 AM. Senter, Peter. Potent antibody-based conjugates for cancer therapy: From early stage research to clinically approved drugs and beyond [Abstract]
TOXI 17. 9:30 AM. Schutten, Melissa. Investigating nonclinical strategies to modify PBD Antibody Drug Conjugate-related toxcities [Abstract]
TOXI 18. 10:10 AM. Solis, Willy. Nonclinical safety evaluation of site-specific antibody-drug conjugates [Abstract]
TOXI 19. 10:50 AM. Reddy, Jagath. Insights to developing nextgen antibody drug conjugates [Abstract]
Monday Aug 17, 2020
Metabolism of Fluorinated Compounds and Safety Relevance
Organizers: Nicholas Meanwell, and Fred Guengerich
TOXI 20. 1:35 PM. Meanwell, Nicholas. Applications of fluorine in drug design [Abstract]
TOXI 21. 2:15 PM. Johnson, Benjamin. Metabolic and pharmaceutical aspects of fluorinated compounds [Abstract]
TOXI 22. 3:10 PM. Xu, Qiuwei. Assessment of defluorination of fluorinated drugs in animal models [Abstract]
TOXI 23. 3:50 PM. Jeschke, Peter. Latest generation of fluorine-containing agrochemicals [Abstract]
Tuesday Aug 18, 2020
Genome-wide Perspectives on the Formation, Repair, and Consequences of DNA Damage
Organizers: Sabrina Huber and Maureen McKeague
TOXI 24. 8:05 AM. Fleming, Aaron. Mechanistic Studies of 8-Oxoguanine in Non-canonical Structures Impacting Gene Expression [Abstract]
TOXI 25. 8:40 AM. Püllen, Nikolai. Nucleotide resolution mapping of DNA oxidation in the human genome [Abstract]
TOXI 26. 9:00 AM. McKeague, Maureen. Genome-wide distribution profiles of DNA damage [Abstract]
TOXI 27. 9:20 AM. Delaney, Sarah. Global repair fingerprinting of glycosylase activity on nucleosomes [Abstract]
TOXI 28. 10:15 AM. Essigmann, John. Mutational spectra provide insight into the mechanisms bridging DNA damage to genetic disease [Abstract]
TOXI 29. 10:50 AM. Wyrick, John. Mutational signatures induced by atypical UV photoproducts are associated with driver mutations in melanoma [Abstract]
TOXI 30. 11:25 AM. Mingard, Cécile. Polymerase zeta¶ mutational spectrum following alkylating agent exposure [Abstract]
Tuesday Aug 18, 2020
Chemical Research in Toxicology Young Investigator Award Symposium
Organizers: Elijah Peterson
TOXI 31. 1:35 PM. Xia, Menghang. Profiling environmental chemicals using in vitro qHTS methods [Abstract]
TOXI 32. 2:15 PM. Sharma, Monita. In Vitro approaches for assessing respiratory toxicity [Abstract]
TOXI 33. 3:10 PM. Reipa, Vytas. Measurement issues in the phototoxicity of nanomaterials [Abstract]
TOXI 34. 3:55 PM. Petersen, Elijah. Advances in the reliability of nanotoxicity assays [Abstract]
Tuesday Aug 18, 2020
Keynote Lecture
Organizers: Natalia Tretyakova
TOXI 35. 5:05 PM. Burrows, Cynthia. Free radical oxidation of guanine in DNA—mutagenic or epigenetic? [Abstract]
Tuesday Aug 18, 2020
Poster Session
Organizers: Penny Beuning and Erin Prestwich
TOXI 36. 6:30 PM. Jokipii Krueger, Caitlin . Endogenous versus exogenous sources of N7-(2,3,4-trihydroxybut-1-yl) guanine and N7-(1-hydroxyl-3-buten-1-yl) guanine DNA adducts [Abstract]
TOXI 37. 6:30 PM. Fukuhara, Kiyoshi. Generation of reactive oxygen species following photoirradiation of nitromusks [Abstract]
TOXI 38. 6:30 PM. Ohno, Akiko. Application to toxicity evaluation of titanium dioxide nanoparticles based on physicochemical properties using multivariate analysis method [Abstract]
TOXI 39. 6:30 PM. Muller, Fabrice. In vitro and in silico testing strategies for predicting human liver toxicity from foodborne chemicals [Abstract]
TOXI 40. 6:30 PM. Brown, Brandon. Systematic review for DPR human health risk assessments: best practices as applied to case studies with allyl isothiocyanate, methomyl, and linuron [Abstract]
TOXI 41. 6:30 PM. Kyzer, Jillian. Investigation of the mechanism of immunologic response to chronic opioid use [Abstract]
TOXI 42. 6:30 PM. Geier, Mitra. Allyl isothiocyanate (AITC) hazard identification [Abstract]
TOXI 43. 6:30 PM. Blake, Timothy. Synthesis and reproductive toxicity of bisphenol analogs [Abstract]
TOXI 44. 6:30 PM. Jiang, Yang. Genome-wide sequencing of 5′-aldehyde lesions resulting from DNA oxidation [Abstract]
TOXI 45. 6:30 PM. Chen, Jin. Identification and toxicity evaluation of carbonyl emissions from vaping of alcohol-containing flavored e-liquids [Abstract]
TOXI 46. 6:30 PM. Liu, Jia | Jacob, Peyton. 1-(3-Pyridinyl)-1,2-dihydroxyethane (3-pyridylethylene glycol) is excreted in smokers’ urine. Evidence for metabolic epoxidation of 3-ethenylpyridine from inhaled tobacco smoke [Abstract]
TOXI 47. 6:30 PM. Fairman, Kiara. Contribution of parameter sensitivities to the predictive potential of pregnancy-induced pharmacokinetic changes for antihypertensives using physiologically based pharmacokinetic (PBPK) modeling [Abstract]
TOXI 48. 6:30 PM. DeMott, Michael. Phosphorothioate DNA modification in human gut microbiome [Abstract]
TOXI 49. 6:30 PM. Stornetta, Alessia. Analysis of double-stranded oligodeoxynucleotides crosslinked by the bacterial genotoxin colibactin using HILIC chromatography and high-resolution mass spectrometry [Abstract]
TOXI 50. 6:30 PM. Chen, Yitzai | Li, Deyu. Sequence effects of 4-aminobiphenyl DNA lesion-induced mutational spectra [Abstract]
TOXI 51. 6:30 PM. Wang, Jie | Li, Deyu. Structure and mutagenicity of cinnamaldehyde-induced DNA adducts [Abstract]
TOXI 52. 6:30 PM. Sun, Jingjing. Molecular beacon reporters of substrate specificity of DNA 8-oxoguanine glycosylase mutants [Abstract]
TOXI 53. 6:30 PM. Petersen, Elijah. Using a measurement science approach to Increase confidence in the EASA skin sensitization assay [Abstract]
TOXI 54. 6:30 PM. Bellamri, Medjda. Cytotoxicity and genotoxicity of tobacco smoke carcinogens in human bladder cells [Abstract]
TOXI 55. 6:30 PM. Li, Yupeng. Identification of N’-Nitrosonornicotine (NNN)-specific DNA Adduct N6-[4-Hydroxy-1-(pyridine-3-yl)butyl]-2′-deoxyadenosine in Rat Liver [Abstract]
TOXI 56. 6:30 PM. Guo, Jingshu. Development of DNA Adductome Mass Spectral Database [Abstract]
TOXI 57. 6:30 PM. Oketola, Adebola. Human exposure risk to dioxin-like PCBs in Nigeria [Abstract]
TOXI 58. 6:30 PM. Narang, Ajit. Difficult path to simple: enabling discovery to development transition [Abstract]
TOXI 59. 6:30 PM. Thorp, Clare. Development of a framework for evidence-based risk assessment of potential carcinogens in human diets [Abstract]
TOXI 60. 6:30 PM. Bacurio, Jan Henric. Translesion synthesis of Fapy-dG in human cells is dependent on DNA sequence contexts [Abstract]
Wednesday Aug 19, 2020
Chemical Exposures and Impact on Health
Organizers: Rob Turesky and Sarah Shuck
TOXI 61. 8:05 AM. Pennell, Kurt. Application of high-resolution mass spectrometry for assessment of environmental exposures and metabolic responses [Abstract]
TOXI 62. 8:45 AM. DeWitt, Jamie. Mechanisms of toxicity for per- and polyfluoroalkyl substances: Are we there yet? [Abstract]
TOXI 63. 9:25 AM. Sobus, Jon. EPA’s research initiatives on non-targeted analyses of environmental chemicals [Abstract]
TOXI 64. 10:20 AM. Lein, Pamela. Sulfated persistent organic pollutants (POPs): mechanistic studies of an emerging class of neurotoxic chemicals [Abstract]
TOXI 65. 11:00 AM. Balshaw, David. NIEHS efforts in exposure science and the exposome [Abstract]
Wednesday Aug 19, 2020
Topics in Chemical Toxicology
Organizers: Linlin Zhao and Penny Beuning
TOXI 66. 1:00 PM. Turesky, Robert. Targeted and untargeted screening of DNA adducts in the genome of prostate cancer patients [Abstract]
TOXI 67. 1:20 PM. Boysen, Gunnar. Detection and discrimination of DNA adducts differing in size, regiochemistry and functional group by nanopore sequencing [Abstract]
TOXI 68. 1:40 PM. Peterson, Lisa. Acrolein increases the pulmonary tumorigenic activity of the tobacco specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) [Abstract]
TOXI 69. 2:00 PM. Stone, Michael. Structure of a stable interstrand DNA crosslink involving a β-N-Glycosyl linkage between an N6-dA amino group and abasic (AP) site [Abstract]
TOXI 70. 2:20 PM. Scharer, Orlando. Replicative and translesion synthesis DNA polymerases in ICL repair [Abstract]
TOXI 71. 2:40 PM. Geacintov, Nicholas. Impact of molecular structure and DNA adduct conformation on the repair and helicase-driven DNA unwinding step in human cell-free assays [Abstract]
TOXI 72. 3:20 PM. Suo, Zucai. Identification and investigation of a novel function of the RuvC nuclease of CRISPR/Cas9 [Abstract]
TOXI 73. 3:40 PM. Zhao, Linlin. Mitochondrial DNA degradation: The potential moonlighting function of mitochondrial transcription factor A [Abstract]
TOXI 74. 4:00 PM. Shafirovich, Vladimir. Interplay of nucleotide excision repair and base excision repair pathway in plasmid DNA substrates harboring oxidatively generated guanine lesions [Abstract]
TOXI 75. 4:20 PM. Yan, James. Evaluation of persistent, bioaccumulative, toxic chemicals under the Frank R. Lautenberg chemical safety for the 21st century act [Abstract]
TOXI 76. 4:40 PM. Kim, Sunghwan. Toxicological information in PubChem [Abstract]