TOXI Program American Chemical Society Meeting 2019

Sunday , August 25, 2019.

Translation Aspects of DNA Repair.

TOXI 1. 8:35 AM. Harry B Gray Electron flow through proteins ACS Link

TOXI 2. 9:10 AM. Lawrence Joseph Marnett Competition between repair and oxidation of the endogenous DNA adduct, 3(2-deoxy-beta-D-erythro-pentofuranosyl)pyrimido[1,2-alpha]purin-10(3H)-one (M1dG) ACS Link

TOXI 3. 9:45 AM. Irene Chiolo Highways for repair of heterochromatic DNA breaks ACS Link

TOXI 4. 10:35 AM. John S Termini Hyperglycemia induced DNA damage and inhibition of DNA repair: Potential mechanistic link between diabetes and increased cancer risk ACS Link

TOXI 5. 11:10 AM. Yilun Liu SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts ACS Link

Sunday , August 25, 2019.

Founder’s Award Symposium: The Role of Carbonyl Metabolism in Health & Disease.

TOXI 6. 1:25 PM. Lawrence Joseph Marnett Histone modification by bifunctional electrophiles derived from lipid and carbohydrate metabolism ACS Link

TOXI 7. 2:05 PM. Ian Alexander Blair Interactions of aldehydic bifunctional electrophiles and high mobility group box-1 with RAGE ACS Link

TOXI 8. 3:00 PM. Vasilis Vasilou Aldehyde dehydrogenases: From metabolic and alcohol-related diseases to cancer stem cells ACS Link

TOXI 9. 3:40 PM. John Duncan Hayes Aldo-keto reductases and NRF2 ACS Link

TOXI 10. 4:20 PM. Trevor M Penning Role of human aldo-keto reductases (AKRs) in hormonal & chemical carcinogenesis ACS Link

Monday , August 26, 2019.

Student & Post-Doctoral Scholar Symposium.

TOXI 11. 8:00 AM. Jenna Fernandez Epigenetic changes in alveolar type II lung cells of A/J mice following exposure to cigarette smoke and LPS ACS Link

TOXI 12. 8:20 AM. Immaculate Sappy | Mel Fernand Bedi Oxidation of RNA at naturally occurring modifications ACS Link

TOXI 13. 8:40 AM. Elizabeth Rose Lotsof DNA glycosylase NEIL1 demonstrates lesion specificity from RNA editing ACS Link

TOXI 14. 9:00 AM. Judy Zhu Sequencing for 8-oxo-7,8-dihydroguanine in a mammalian genome before and after oxidative stress ACS Link

TOXI 15. 9:20 AM. Prabha Ranasinghe Embryonic exposure to 2, 2′, 3, 5′, 6 polychlorinated biphenyls (PCB-95) alters GABAgenic and antioxidant transcriptome in zebrafish ACS Link

TOXI 16. 9:40 AM. Jessica R Murray Nrf2 signaling increases bioactivation of the mutagenic air pollutant 3-nitrobenzanthrone ACS Link

TOXI 17. 10:15 AM. Kurt Housh Interstrand cross-links at strand breaks derived from abasic sites in duplex DNA ACS Link

TOXI 18. 10:35 AM. Jiabin Wu Replicative bypass and mutagenic properties of alkylphosphotriester lesions in Escherichia coli ACS Link

TOXI 19. 10:55 AM. Arnold Groehler Development of an ultra performance liquid chromatography-mass spectrometry (UPLC-MS) assay for the quantification of cisplatin-Induced DNA intra- and interstrand cross-links ACS Link

TOXI 20. 11:15 AM. Morwena J Solivio High-resolution/accurate-mass DNA adductomics to identify adducts formed by the hypoxia-activated alkylating agent, CP-506 and its metabolites ACS Link

TOXI 21. 11:35 AM. Yupeng Li Identification of a new N’-nitrosonornicotine (NNN)-specific DNA adduct N6-((5-(3-pyridyl)tetrahydrofuran-2-yl)-2′-deoxyadenosine in rat liver ACS Link

Monday , August 26, 2019.

Current Approaches to Discovery Phase Safety Assessment in the Industry.

TOXI 22. 2:05 PM. Mark Fielden Strategies for early safety assessment of potential drug candidates at Amgen and lessons learned ACS Link

TOXI 23. 2:35 PM. Joseph R Piccotti Early safety assessment strategies for drug discovery at Celgene and lessons learned ACS Link

TOXI 24. 3:05 PM. Russell Naven Strategies towards the design of safer compounds at Takeda and lessons learned ACS Link

TOXI 25. 3:35 PM. Kevin James Coe Reactive metabolism strategy applied to drug safety assessment: Focus on risk prevention ACS Link

TOXI 26. 2:05 PM. Michael Gill Strategies for early safety assessment of potential drug candidates at Bristol-Myers Squibb: Preclinical evaluation of hepatobiliary toxicity ACS Link

TOXI 27. 4:35 PM. Kaushik Mitra Integrated platform, utilizing transcriptomic profiling and metabolite identification studies, to derisk drug bioactivation-mediated liver injury ACS Link

Tuesday , August 27, 2019.

Emerging Topics in Chemical Toxicology.

TOXI 28. 8:05 AM. Antony John Williams Delivering web-based access to data and algorithms to support computational toxicology: US EPA CompTox Chemicals Dashboard ACS Link

TOXI 29. 8:40 AM. Bradley Ringeisen DARPA’s microphysiological systems (MPS) program ACS Link

TOXI 30. 9:15 AM. Sheila Sue David Dare to repair: From DNA chemistry to cancer ACS Link

TOXI 31. 10:05 AM. Irina Stepanov E-cigarette aerosols for in vitro and in vivo toxicology studies: Key considerations ACS Link

TOXI 32. 10:40 AM. Robert Sobol Developing DNA repair pathway specific genotoxic signatures ACS Link

Tuesday , August 27, 2019.

Chemical Research in Toxicology Young Investigator Award Symposium.

TOXI 33. 2:05 PM. Gary Patti  Annotating the small-molecule exposome by subtraction ACS Link

TOXI 34. 2:40 PM. Peter W Villalta E.coli-produced genotoxin colibactin: DNA adduct identification using untargeted adductomics and in vivo detection using high resolution mass spectrometry ACS Link

TOXI 35. 3:30 PM. Jiri Zavadil Integrative experimental modelling reveals novel genome-scale mutation fingerprints of carcinogens ACS Link

TOXI 36. 4:05 PM. Silvia Balbo High resolution mass spectrometry-based approaches for the investigation of chemical carcinogenesis ACS Link

Tuesday , August 27, 2019.

Keynote Address.

TOXI 37. 5:00 PM. Brian Berridge Embracing translation in toxicology: National toxicology program strategy ACS Link

Poster Session.

TOXI 38. 7:00 PM. Niladri Bhowmik Combined in vitro assays for eye irritation assessment ACS Link

TOXI 39. 7:00 PM. Byeong Hwa Yun Kinetics of formation and removal of DNA adducts in mice exposed to tobacco and meat carcinogens by UPLC-mass spectrometry ACS Link

TOXI 40. 7:00 PM. Jiehong Guo Mass spectrometric quantitation of apurinic/apyrimidinic sites in tissues of rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N’-nitrosonornicotine ACS Link

TOXI 41. 7:00 PM. Brent V Powell Mutagenicity of the C8-adenine adduct derived from the environmental carcinogen 6-nitrochrysene in Escherichia coli and human cells ACS Link

TOXI 42. 7:00 PM. Hong Mu Rad4/XPC initial binding discriminates repair-resistant lesions from efficiently-repaired ones in global genomic nucleotide excision repair ACS Link

TOXI 43. 7:00 PM. Guannan Zhang Elucidating the roles of estrogens in the development and prognosis of malignant pleural mesothelioma ACS Link

TOXI 44. 7:00 PM. Kurt Housh Facile synthesis of DNA duplexes containing a chemically-defined, derivatizable, covalent cross-link ACS Link

TOXI 45. 7:00 PM. Michael Malfatti Iterative approach for the development of a CNS-active oxime reactivator for nerve agent exposure ACS Link

TOXI 46. 7:00 PM. Melissa Lizette Liriano Probing the thermostability and DNA loading efficiency of beta sliding clamp variants with perturbed dimer interfaces ACS Link

TOXI 47. 7:00 PM. Pamela Cebrowski Application of a read-across approach to address data gaps in human health screening level risk assessments and the chemicals management plan ACS Link

TOXI 48. 7:00 PM. Katherine Hurley Endogenous microbial generation of acrolein: Strategies to assess the effects of intestinal acrolein formation ACS Link

TOXI 49. 7:00 PM. Rui Qi Effect of sequence context on 1, N6-ethenoadenine repair by the AlkB family DNA repair enzymes ACS Link

TOXI 50. 7:00 PM. James Starr Is food type important for in vitro post ingestion bioaccessibility models of polychlorinated biphenyls sorbed to soil ACS Link

TOXI 51. 7:00 PM. Spandana Naldiga Translesion synthesis past DNA-peptide crosslinks is dependent on local DNA sequence context ACS Link

TOXI 52. 7:00 PM. Jun Yuan Replication studies of chemically stable analogs of N7-methylguanine and N3-methyladenine in Escherichia coli cells ACS Link

TOXI 53. 7:00 PM. James McIsaac Probing interactions between E. coli DNA polymerase III and single-stranded DNA binding protein to gain insights into polymerase management ACS Link

TOXI 54. 7:00 PM. Guang Cheng Quantitation of carboxyethylguanine adducts in leukocyte DNA from smokers and nonsmokers using LC-NSI-HRMS/MS ACS Link

TOXI 56. 7:00 PM. Jun Yuan Replication studies of purine 5′,8-cyclonucleosides in cells ACS Link

TOXI 57. 7:00 PM. YiTzai Chen DNA base sequence effects on 4-aminobiphenyl lesion-induced mutational spectra ACS Link

TOXI 58. 7:00 PM. Ying Tan Human translesion synthesis DNA polymerases function in transcriptional bypass and repair of N2-alkyl-2′-deoxyguanosine lesions ACS Link

TOXI 59. 7:00 PM. Li Zhang Evaluation of tobacco smoke and diet as sources of exposure to two heterocyclic aromatic amines for the U.S. population: NHANES 2013-2014 ACS Link

TOXI 60. 7:00 PM. Qiyuan Han Multi-omics characterization of an inflammatory bowel disease mouse model ACS Link

TOXI 61. 7:00 PM. HENGJIANG LIU Heavy metal toxicants deposition and destruction in pulmonary surfactant layer: Classical density functional prediction ACS Link

TOXI 62. 7:00 PM. Alexander Siyasatovich Bunev Investigation of kinase inhibitor hepatotoxicity with induced pluripotent stem cell-derived hepatocytes ACS Link

TOXI 63. 7:00 PM. Gurdat Premnauth Reactive oxygen species-activated DNA damage agents to selectively targeting cancer by oxidative-cyclizing ACS Link

TOXI 64. 7:00 PM. Xu Guo Unhooking of DNA-DNA interstrand cross-links by the base excision repair glycosylase NEIL3 ACS Link

TOXI 65. 7:00 PM. Eun Ko | Songhee Lee Oxidative stress and mitochondrial dysfunction in tail of zebrafish induced by persistent organic pollutant ACS Link

TOXI 66. 7:00 PM. Arnold Groehler Studying the assembly of nucleotide excision repair complexes by biochemical and crosslinking mass spectrometry approaches ACS Link

TOXI 67. 7:00 PM. Jingjing Sun  DNA probe-based screening strategy for selectivity engineering of 8-oxoguanine glycosylase ACS Link

TOXI 68. 7:00 PM. Ryan Dilworth Mapping the interactions of UmuD and the beta clamp loader in E. coli ACS Link

TOXI 69. 7:00 PM. Junzhou Wu Amplification and sequencing of 5′-aldehyde lesions resulting from DNA oxidation ACS Link

TOXI 70. 7:00 PM. Carlos Antonio Hernandez MG-adducts as biomarkers of metabolic disease ACS Link

TOXI 71. 7:00 PM. Cindy Khuu Investigating the metabolic and biological effects of glyoxalase 1 inhibition and knockdown in cancer cell lines ACS Link

TOXI 72. 7:00 PM. Rachana Tomar Structural insights into aflatoxin B1 (AFB1)-associated mutational spectrum ACS Link

TOXI 73. 7:00 PM. Clementina Mesaros Environmental polycyclic aromatic hydrocarbons and risk of lung cancer in never smokers ACS Link

TOXI 74. 7:00 PM. Chidiebere Amarachi Dim Independent synthesis and fate of DNA lesions generated from oxidative damage at the C-5′ of thymidine ACS Link

TOXI 76. 7:00 PM. Jianbo Zhang  Chemical metabolism and toxicological relevance of microbial glycerol dehydratase from human gut microbiota ACS Link

TOXI 77. 7:00 PM. Jonathan Sczepanski Investigating base excision repair using “designer” chromatin ACS Link

TOXI 78. 7:00 PM. Salako N Olatunji Medical countermeasures for the individual service member to maintain combat effectiveness and prevent or reduce injury from the battlefield ACS Link

TOXI 79. 7:00 PM. Kai Luo Multiple deuterated phenanthrene metabolites as probes for the metabolism of carcinogenic PAHs in humans: Phenotyping, genotyping and potential application in human health risk assessment ACS Link

TOXI 80. 7:00 PM. Feng Tang Base-resolution analysis of thymine glycol (Tg) in DNA by polymerase-aided differential coding ACS Link

TOXI 81. 7:00 PM. Medjda Bellamri Biological effects of the cooked meat carcinogen PhIP in human prostate cancer ACS Link

TOXI 82. 7:00 PM. Takafumi Takai Evaluating the value of primary human cells for the prediction of in vivo toxicity in early drug discovery ACS Link

TOXI 83. 7:00 PM. Isabelle Lee Estrogenic activity of polycyclic aromatic hydrocarbon metabolites in human endometrial cells ACS Link

TOXI 84. 7:00 PM. Cindy Khuu Investigating the role of cysteine oxidation by environmentally induced oxidative stress on the DNA glycosylase MUTYH ACS Link

TOXI 85. 7:00 PM. Shawna Vreeke Underestimation of toxin levels in the aerosol of electronic cigarettes ACS Link

TOXI 86. 7:00 PM. Valeria Guidolin DNA damage as a toxicity mechanism of NMC (LixNi1/3Mn1/3Co1/3O2) nanomaterial to bacteria Shewanella oneidensis MR-1 and Bacillus subtilis ACS Link

TOXI 87. 7:00 PM. Gurdat Premnauth Reactive oxygen species (ROS)-dependent release of an anticancer drug from a targeting peptide ACS Link

TOXI 88. 7:00 PM. Spandana Naldiga Translesion synthesis of tandem DNA lesions containing 2-deoxyribonolactone 5′ to thymine glycol in human cells ACS Link

TOXI 89. 7:00 PM. Marie Bourgeois Evaluation of postnatal Chlorpyrifos administration in rat pups ACS Link

TOXI 90. 7:00 PM. Stanley K. Mauldin Expression of the catalytic domain of DNA polymerase zeta from dictyostelium discoideum ACS Link

TOXI 91. 7:00 PM. Akrimah Akrimah Synthesis and study of RNA oxidative damage product, 3′-deoxy-3′,4′-didehydrouridine-5′-aldehyde ACS Link

TOXI 92. 7:00 PM. Eun Ko Unregulated Mitochondrial function exposed in Persistent organic pollutants Mixture ACS Link

Wednesday , August 28, 2019.

Epigenetic Response to Endogenous & Exogenous Toxins.

TOXI 93. 8:05 AM. Natalia Yurievna Tretyakova Epigenetic regulation via oxidized forms of Me C and inflammation-mediated epigenetic deregulation ACS Link

TOXI 94. 8:40 AM. Yael David Reversible histone glycation drives disease-associated changes in chromatin architecture ACS Link

TOXI 95. 9:15 AM. Aaron M Fleming Base modifications in DNA non-canonical structures regulate transcription ACS Link

TOXI 96. 10:05 AM. Dong Wang Transcription-coupled recognition of DNA lesions and endogenous epigenetic modifications ACS Link

TOXI 97. 10:40 AM. Yinsheng Wang Targeted quantitative proteomic approaches toward understanding epitranscriptomic regulations ACS Link

Wednesday , August 28, 2019.

Topics in Chemical Toxicology.

TOXI 98. 1:00 PM. Mukund Chorghade Magic of the chemosynthetic livers which is the best porphyrin ACS Link

TOXI 99. 1:20 PM. Chris Vulpe Genome-wide CRISPR screening to identify modulators of formaldehyde toxicity in erythroid cells ACS Link

TOXI 100. 1:40 PM. Hauh-Jyun Candy Chen Higher advanced oxidative modifications in hemoglobin of oral cancer patients as measured by nanoflow liquid chromatography tandem mass spectrometry ACS Link

TOXI 101. 2:00 PM. Vladimir Shafirovich Competitive binding of human DNA glycosylase hNEIL1 and DNA damage-sensing factor XPC-RAD23B to oxidatively generated guanine lesions ACS Link

TOXI 102. 2:20 PM. Michael P Stone Probing chemical biology of DNA damage using NMR ACS Link

TOXI 103. 2:40 PM. Rachelle Joyce Bienstock Molecular modeling of genotoxic azo dyes, Sudan I and Sudan II, and their metabolites ACS Link

TOXI 104. 3:20 PM. Neelam Vaidya Comprehensive toxicity information of every chemical for better R&D decisions ACS Link

TOXI 105. 3:40 PM. Peter Byrley Emission of respirable particles from fused deposition modeling 3D printers ACS Link

TOXI 106. 4:00 PM. Gunnar Boysen Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines ACS Link

TOXI 107. 4:20 PM. Lisa A Peterson Carbon dioxide enhances the pulmonary tumorigenic activity of the tobacco specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) ACS Link

TOXI 108. 4:40 PM. Michael J Calandra Oxidative decarboxylation of 2-oxoacids by hydroperoxides can be used to lower peroxide values in citrus oils ACS Link