October 2019 Newsletter
- Message from Chair, Shana Sturla
- Look back at 2019 TOXI Program. Thomas Spratt
- Awards to Graduate Student and Post-doctoral Presentations
- Travel awards to 2019 ACS Meeting
- Biosketches for TOXI Election
Message from Chair
Dear Members of the Division of Chemical Toxicology
I hope this newsletter finds you well and eager to hear about our outstanding candidates for openings in the Executive Committee as well as the recent successes of our members and activities at the Fall ACS meeting in San Diego at the end of August!
Our division is comprised of over 1,000 scientific members, about half student members at various stages of training, and half members in regular standing. Our major goals are to provide a forum for communicating research in the field of chemical toxicology, promoting research in this area, and to support education and career development opportunities. These efforts are organized by the members of the Executive Committee of the Division, and supported by members of the various committees they lead. Executive Committee members volunteer their time, energy, and creativity to advance the goals of the division and provide outstanding opportunities for all members. As Chair of the division, I lead this great committee, and it is now the time of year for new members to be elected. Our Nominations Committee has identified nominees who are ready to serve the division in the positions that need to be filled for 2020—the open positions and Scientific Bios of current candidates can be found in this newsletter: http://www.acschemtox.org/biosketches-2019/.
You are now invited to nominate additional candidates for the Exec Committee—you can do this by directly sending your nominations to me at firstname.lastname@example.org within the next week please. You will all thereafter receive a personalized link to vote for Exec Committee members….please vote!
Looking back at our Scientific Program at the ACS National Meeting in San Diego, I would like to enthusiastically acknowledge Professor Tom Spratt who has served as Program Chair for three years of excellent programming. The 2020 Programming is well underway under the leadership of our new Program Chair, Professor Penny Beuning. Stay tuned for highlights of the upcoming program in our next newsletter and follow the activities of members during the meeting and throughout the year on Facebook and Twitter.
Please enjoy reading further in this newsletter about the meeting, particularly including introductions of our amazing student and postdoc presentation and travel award winners. Congratulations and keep up the great work! You are the future of our scientific community and the Padres, Red Sox and Dodgers fans in San Diego this August were all cheering for you!!
Division of Chemical Toxicology
Look Back at the Division of Chemical Toxicology Program at the American Chemical Society National Meeting
by Thomas Spratt, outgoing program chair.
The Program Committee thanks the NIEHS, Chemical Research in Toxicology, the ACS, TOXI members, and Frederick and Susan Beland for funding our program. Review the Program and read the abstracts.
The TOXI program began early on Sunday morning with Harry Gray entertaining us with his experiments investigating electron movement within proteins. This session revolving on Translation Aspects of DNA repair also included talks by Lawrence J Marnett, Irene Chiolo, John S Termini, and Yilun Liu. This session was organized Sarah Shuck. This was the first time that Sarah organized a session for TOXI, and it was an outstanding, very well-attended session.
Sunday afternoon was the Founders’ Award symposium organized by this year’s winner Trevor Penning. The Founders’ Award is given by the Division of Chemical Toxicology to members whose work exemplifies excellence and innovation in the general field of chemical toxicology. Trevor Penning has performed outstanding research in the areas of chemical toxicology and environmental science with over 500 publication. His research interest is in the role of aldo-keto reductases (AKRs) in intracrine hormone biosynthesis as it relates to prostate and breast cancer; and the development of inhibitors for said enzymes as chemical probes and therapeutics. Trevor invited Lawrence J Marnett, Ian A Blair, Vasilis Vasilou and John D Hayes to speak at the symposium in his honor on the topic of The Role of Carbonyl Metabolism in Health & Disease. Read more
Trevor is the second individual from the University of Pennsylvania to win the Founder’s Award; Ian Blair won it two years ago. Vanderbilt University (Larry Marnett and Fred Guengerich) and NYU (Nicholas Geacintov and Susy Brode) have also produced two Founders’ Award winners.
For those keeping score, Larry Marnett was invited to present two talks, in the Translational Aspects of DNA repair symposium he presented Competition between repair and oxidation of the endogenous DNA adduct, 3(2-deoxy-β-D-erythro-pentofuranosyl)pyrimido[1,2-α]purin-10(3H)-one (M1dG) while in the Founders’ Symposium he presented Histone modification by bifunctional electrophiles derived from lipid and carbohydrate metabolism, However Larry was not alone in having multiple presentations at this year’s meeting. Arnold Groehler traveled from South Korea to present a talk at the TOXI Young Investigators symposium Development of an Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) Assay for the Quantification of Cisplatin-Induced DNA Intra- and Interstrand Cross-Links, in addition to a poster Studying the assembly of nucleotide excision repair complexes by biochemical and crosslinking mass spectrometry approaches. Not to be outdone, Kurt Housh also present a talk Interstrand cross-links at strand breaks derived from abasic sites in duplex DNA and a poster Facile synthesis of DNA duplexes containing a chemically-defined, derivatizable, covalent cross-link.
On Monday Morning we had our TOXI young investigator symposium. This symposium featured eleven talks by graduate students and post-doctoral scholars. As outgoing program chair, I thank Erin Prestwich and Ujjal Sarkar for organizing this event for the past three years. We present awards to outstanding presentations. This year the winning graduate students were (1) Jessica R Murray, from Trevor M Penning’s lab, (2) Jenna Fernandez, from Natalia Y Tretyakova’s lab and (3) Judy Zhu from Cindy Burrows’ lab. The post-doc winners were (1) Arnold Groehler (Orlando Schärer’s lab) and Yupeng Li (Stephen S Hecht’s lab)
On Monday Afternoon we had a joint symposium between TOXI and the Divisional of Medicinal Chemistry. Fred Guengerich and Nick Meanwall organized a symposium entitled Current Approaches to Discovery Phase Safety Assessment in the Industry. In this symposium , scientist for six pharmaceutical companies described how they examine the safety of new drugs: Mark Fielden (Amgen), Joseph R Piccotti (Celgene), Russell Naven (Takeda), Kevin J Coe (Janssen), Michael Gill (Bristol-Myers Squibb), and Kaushik Mitra (Merck). In my tenure as Program Chair, Fred and Nick organized three outstanding MEDI-TOXI joint symposia. I thank them for their innovative ideas in drug toxicology topics
On Tuesday morning our symposium was our new Emerging Topics of Chemical Toxicology. This session differed from our other thematic symposia in that the topics were not on a specific theme, but focused on innovative and/or timely research. This year Antony J Williams discussed the EPA’s CompTox Chemicals Dashboard; Sheila S David discussed the connection between DNA Chemistry to Cancer; Irina Stepanov key considerations in designing E-cigarette in vitro and in vivo toxicology studies:and Robert Sobol identifying genotoxic signatures of DNA repair deficiencies. If you enjoyed this type of symposium, let new Program Chair Penny Beuning or Program Chair-Select Michael Trakselis know.
On Tuesday afternoon, we attended the Chemical Research in Toxicology Young Investigator Symposium. This award is given to an investigator within 15 years of receiving a PhD making significant contributions studying mechanisms of toxicity of exogenous or endogenous compounds. Silvia Balbo won the award this year for her work on tobacco and e-cigarettes. Previous winners were Yinsheng Wang, Dean Naisbitt, Shana Sturla, Penny Beuning, Yimon Aye, Huiwang Ai, and Simon Chan.
Tuesday afternoon continued with the Keynote Lecture give by Brian Berridge, the Associate Director of the US National Toxicology Program. He discussed his vision of how the NTP will evaluate toxicants in a talk entitled “Embracing translation in toxicology: National toxicology program strategy.”
Tuesday Evening culminated with our Reception, Poster Session and Business Meeting. Our reception consisted of crudite, pasta, flautas and a cash bar. The science in the posters was excellent. Awards for top poster presentations were given to:graduate students Ying Tan (Yinsheng Wang lab), Jiehong Guo,(Stephen S Hecht lab) and Brent V Powell, (Ashis K Basu lab). Post-doc winners were Medjda Bellamri (Rob Turesky lab); Kai Luo, (Stephen Hecht lab) and Cindy Khuu (Sheila S David lab)
On Wednesday morning, Natalia Tretyakova and Yinsheng Wang organized a symposium entitled “Epigenetic Response to Endogenous & Exogenous Toxins.” In addition to Natalia and Yinsheng, Aaron Fleming, Yael David and Dong Wang discussed their current research. On Wednesday Afternoon, the last session consisted of 11 short talks of contributed papers. I thank Penny Beuning and Lin Zhao for organizing and presiding over this session.
The Division of Chemical Toxicology presented awards to outstanding oral and poster presentation.
Graduate Student Awards
Jessica R Murray, Laureano de la Vega, John D Hayes, Trevor M Penning Nrf2 signaling increases bioactivation of the mutagenic air pollutant 3-nitrobenzanthrone
Jenna Fernandez, Qiyuan Han, Andrew Rajczewski, Christopher Seiler, Alexander Lee, Natalia Y Tretyakova Epigenetic changes in alveolar type II lung cells of A/J mice following exposure to cigarette smoke and LPS
Judy Zhu, Aaron M Fleming, Cynthia Burrows Sequencing for 8-oxo-7,8-dihydroguanine in a mammalian genome before and after oxidative stress
Post-doctoral scholar Awards
Arnold Groehler, Jirawas Sornkom, Orlando Schärer Development of an ultra performance liquid chromatography-mass spectrometry (UPLC-MS) assay for the quantification of cisplatin-Induced DNA intra- and interstrand cross-links
Yupeng Li, Adam T Zarth, Erik S. Carlson, Pramod Upadhyaya, Stephen S Hecht Identification of a new N’-nitrosonornicotine (NNN)-specific DNA adduct N6-((5-(3-pyridyl)tetrahydrofuran-2-yl)-2′-deoxyadenosine in rat liver
Graduate Student Awards
Ying Tan Human translesion synthesis DNA polymerases function in transcriptional bypass and repair of N2-alkyl-2′-deoxyguanosine lesions
Jiehong Guo, Haoqing Chen, Robert J Turesky, Stephen S Hecht Mass spectrometric quantitation of apurinic/apyrimidinic sites in tissues of rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N’-nitrosonornicotine
Brent V Powell, Ashis K Basu Mutagenicity of the C8-adenine adduct derived from the environmental carcinogen 6-nitrochrysene in Escherichia coli and human cells
Post-doctoral scholar Awards
Medjda Bellamri, Christina Brown, Paari Murugan, Christopher Weight, Robert Turesky Biological effects of the cooked meat carcinogen PhIP in human prostate cancer
Kai Luo, Jon Bradley Hochalter, Viviana Paiano, Jing Wang, Christopher Sipe, Steven Carmella, Sharon Elizabeth Murphy, Dorothy Hatsukami, Joni Jensen, Naomi Fujioka, Stephen Lam, Lori Bergstrom, David Midthun, Stephen Hecht Multiple deuterated phenanthrene metabolites as probes for the metabolism of carcinogenic PAHs in humans: Phenotyping, genotyping and potential application in human health risk assessment
Cindy Khuu, Nicole Nunez, Sheila S David Investigating the metabolic and biological effects of glyoxalase 1 inhibition and knockdown in cancer cell lines
Tom Spratt, Ying Tan, Cindy Khuu , Brent Powell, Arnold Groehler, Yupeng Li, Kai Lou, Jiehong Guo, Judy Zhuu, Jenna Fernandez, Jessica Murray, Medjda Bellamri, Shana Sturla
The Division of Chemical Toxicology awarded 15 travel awards to the American Chemical Society National Meeting in San Diego. We than the NIEHS and Frederick and Susan Beland for a generous donation.
Benjamin Cordova, California State University, Northridge, Daniel Tamae, Investigating the metabolic and biological effects of Glyoxalase 1 inhibition and knockdown in cancer cell lines
Valeria Guidolin, UMinn, Silvia Balbo, DNA damage as a toxicity mechanism of NMC (LixNi1/3Mn1/3Co1/3O2) nanomaterial to bacteria Shewanella oneidensis MR-1 and Bacillus subtilis
Cindy Khuu, UC Davis, Sheila David, Investigating the role of cysteine oxidation by environmentally induced oxidative stress on the DNA glycosylase MUTYH
Kurt Housh, U Missouri, Kent Gates , Interstrand cross-links at strand breaks derived from abasic sites in duplex DNA
Hengjiang Liu, East China University , Yazhuo Shang, Heavy metal toxicants deposition and destruction in pulmonary surfactant layer: A classical density functional prediction
Gurdat Premnauth, University of Cincinnati, Ed Marino, Reactive oxygen species (ROS)-dependent release of an anticancer drug from a targeting peptide
Jingjing Sun, ETH, Shana Sturla, A DNA probe based screening strategy for selectivity engineering of 8- oxoguanine glycosylase
Elizabeth Lotsof, UC Davis, Sheila David, DNA glycosylase NEIL1 demonstrates lesion specificity from RNA editing
Rachana Tomar, Vanderbilt, Michael P. Stone, Structural Insights into Aflatoxin B1 (AFB1)-associated Mutational Spectrum
Brent Powell, UConn, Ashis Basu , Mutagenicity of the C8-Adenine Adduct Derived from the Environmental Carcinogen 6-Nitrochrysene in Escherichia Coli and Human Cells
Katherine Hurley, ETH, Shana Sturla, Endogenous Microbial Generation of Acrolein: Strategies to Assess the Effects of Intestinal Acrolein Formation
Yupeng Li, UMinn, Steve Hecht, Identification of A New Nʹ-Nitrosonornicotine (NNN)-specific DNA Adduct N6-((5-(3-pyridyl)tetrahydrofuran-2-yl)-2′-deoxyadenosine in Rat Liver
Jenna Fernandez, UMinn, Natalia Tretyakova, Epigenetic changes in alveolar type II lung cells of A/J mice following exposure to cigarette smoke and LPS
Guannan (Tiffany) Zhang, UPenn, Trevor M. Penning, Elucidating the roles of estrogens in the development and prognosis of malignant pleural mesothelioma
Ryan Dilworth, Northeastern, Penny Beuning, Mapping the interactions of UmuD and the beta clamp loader in E. coli
The 2019 Election.
The 2019 election will begin in one week. Current TOXI members will receive their election credentials via email.
The Treasurer and Treasurer-Elect shall each serve two-year terms. The Treasurer-Elect shall accede to the office of Treasurer at the end of the term of office. The Treasurer shall have charge of the funds of the Division and shall receive payments and make all disbursements subject to the approval of the Executive Committee. A report of the Treasurer shall be submitted to the Division at its annual meeting. The financial portion of this report shall be audited by a qualified external auditor. The Treasurer-Elect shall fulfill the duties of the Treasurer in the absence of the Treasurer.
John Termini is a Professor of Molecular Medicine in the Beckman Research Institute of City of Hope in Duarte California and an Associate Director for the Comprehensive Cancer Center. He is also a member of the Diabetes and Metabolism Research Institute at City of Hope. He is also the Director of Shared Resources for City of Hope and their affiliate, TGen, in Phoenix Arizona. He was recently named a Jackie and Bruce Barron Cancer Research Scholar. Dr. Termini was trained in Organic Chemistry at Columbia University, where he completed both his undergraduate and graduate education prior to moving to Caltech as a Fellow of the American Cancer Society. His research at City of Hope has focused on the chemistry of DNA damage and its impact on genomic instability in relation to cancer and other diseases. Recent studies have focused on DNA damage induced by hyperglycemia as part of the pathophysiology of diabetes, and the ways by which it can enhance genomic instability and cancer risk. His laboratory has developed mass spectrometry approaches in conjunction with tissue culture and animal models to characterize the effects of chronic glucose exposure on DNA damage and repair at the DNA, RNA and protein level. Dr. Termini is an Associate Editor for Bioscience Trends (Japan). He has been a member of the American Chemical Society since 1981 and has been cited as a top tier reviewer for Chemical Research in Toxicology.
Linlin Zhao is an Assistant Professor in the Department of Chemistry at the University of California, Riverside. He received his B.S. degree in Chemistry from Jilin University in China (2005) and Ph.D. degree in Bioanalytical Chemistry from University of Connecticut (2010) under the supervision of Prof. James Rusling and John Schenkman. He worked with Prof. F. Peter Guengerich at the Department of Biochemistry at Vanderbilt University School of Medicine as a postdoctoral fellow focusing on the enzymology of specialized DNA polymerases in the context of bypassing carcinogen-modified DNA. In Aug 2013, he started his laboratory in the Department of Chemistry and Biochemistry at Central Michigan University. In Jul 2019, his laboratory relocated to the Department of Chemistry at University of California, Riverside. Dr. Zhao’s research has centered on the mechanistic enzymology of DNA-interacting proteins, with a focus on DNA replication and repair.
His work provides mechanistic insights into the role of specialized DNA polymerase in bypassing chemical-induced DNA damage and in chemical mutagenesis. Also, his research elucidates the chemical and molecular basis of mitochondrial DNA turnover. Dr. Zhao has published 9 peer-reviewed papers in his independent career and 26 in total in his career. His research has been supported by extramural grants from National Institutes of Health and Department of Defense. Dr. Zhao was the recipient of the 2017 Provost’s Award in research, a top research honor for young faculty at Central Michigan University (given to only two faculty per year). Dr. Zhao has been an active member of ACS TOXI division since he was a graduate student. He has been actively involved in organizing and presiding the session and judging the oral and poster presentations in the past TOXI meetings. He has been a member of the Program Development Committee since 2017.
The duties of the Councilors are to promote the interests of the SOCIETY and of the Division in the Council of the SOCIETY and to carry out the decisions of the Executive Committee and membership as decided at the business meeting of the Division. The Councillor will have a three year term. The runner-up of the election will be the Alternate-Councillor
Ujjal Sarkar, Ph.D., is currently leading drug biotransformation efforts towards a series of small molecule projects from discovery to first-in-human at DMPK Oncology, Boston; AstraZeneca. Dr. Sarkar earned a B.Sc. (Hons.) degree in Chemistry from Presidency College, and a M.Sc. in Bio-organic and medicinal chemistry from the Indian Institute of Technology (I.I.T) Kharagpur. He then moved to the US to pursue a Ph.D. in the areas of anticancer drug design and mechanism of drug action at the University of Missouri-Columbia with Prof. Kent S. Gates. He was fortunate to work with late Prof. Richard N. Loeppky who initiated the establishment of the Div. of Chem. Toxi in 90s. After his Ph.D. degree, Dr. Sarkar joined Prof. Steven R. Tannenbaum’s lab at MIT as a postdoctoral research fellow. He employed novel LCMS based methodologies toward drug metabolism and metabolomics-proteomics-based small/large molecule biomarker discovery to develop 3D microphysiological systems, which was supported by the US Defense Advanced Research Projects Agency (DARPA). Dr. Sarkar was three-time top Young Investigator award winner at the ACS TOXI meetings, and received an outstanding research awards from the Center for Environmental Health Sciences (CEHS) at MIT. In 2018, he received Oncology Innovation and Achievement award from AstraZeneca.
Dr. Sarkar has been an active member in the Division of Chemical Toxicology over 14+ years and has served on several program committees including Program Development Committee and Communication Committee. He had chaired and organized the Young Investigator Oral Symposiums in 2016, 2017, 2018 and 2019. He has contributed to several research papers including JACS, J. Org. Chem, Chem. Res. Toxicol, J. Med. Chem. BMCL, Pharmacometrics & Systems Pharmacology and Drug. Metab. Disposition. He has been a peer reviewer of 10+ journals including from the Royal Society of Chemistry, Elsevier and the American Chemical Society, and has been on two editorial boards. In 2014, he became an elected Fellow of the American Institute of Chemists. He has been a member of American Association for the Advancement of Science (AAAS), American Chemical Society (ACS), International Society for the Study of Xenobiotics (ISSX), and North Eastern Section of American Chemical Society. Dr. Sarkar is actively engaged with Division of Chem Tox. over a decade, and he is continuously bringing new ideas and perspectives to the divisional programs.
Sarah Shuck is an Assistant Research Professor of Molecular Medicine in the Beckman Research Institute at City of Hope. She received her Ph.D. from Indiana University and was a Ruth Kirschstein NIH postdoctoral fellow at Vanderbilt University. Dr. Shuck has been an active ACS member for a decade and has been enthusiastically involved with the Chem Tox division throughout this time. She has presented numerous posters and talks with the division and recently organized a session at the 2019 Fall National Meeting. To support the travel of students and postdocs to the National Meeting, she contributed to the preparation and submission of a successfully funded NIEHS R13 grant. Sarah is a member of the Editorial Advisory Board for Chemical Research in Toxicology and has reviewed numerous manuscripts for this journal. She has also recently initiated a Perspectives series inviting mentees of the leaders of Chemical Toxicology to submit a tribute to their mentor along with a review article focused on their research interests. The goal of this series is to highlight the outstanding mentorship by members of the Chem Tox division and to foster collaborations between investigators. Dr. Shuck is an expert in analytical chemistry and has developed a multiplexed mass spectrometry method to measure analytes for prediction and early diagnosis of diabetes and diabetic kidney disease. In addition to her primary research focus, she collaborates with numerous investigators to establish novel mass spectrometry methods for biomarker measurement.
Members-at-Large to the Executive serve three year terms. The role of this position is two-fold: to help the Chair run the division by providing advise and chairing standing committees, and to learn how the Division is run in order to be an effective future Division Officer.
Erin G. Prestwich is an Assistant Professor in the Department of Medicinal and Biological Chemistry in the College of Pharmacy and Pharmaceutical Sciences at the University of Toledo. She earned a BA in Chemistry from Wellesley College, and a Ph.D. in Chemistry and Chemical Biology from Boston College. Her dissertation dissected mechanisms of oxidized amino acid promoted DNA damage. She was a postdoctoral fellow, research associate, and research scientist at the Massachusetts Institute of Technology where she studied the biochemistries surrounding genetic toxicology, inflammation, and infectious disease. She has also worked as a chemical process engineer and a technology specialist for a prominent Boston patent law firm. She is the author of over one dozen peer reviewed research publications. Erin is committed to helping younger people progress in science and diverse careers. She was the chairperson of the Younger Chemist’s Committee of the Chemistry in Cancer Working Group of the American Association for Cancer Research from 2009-2012 where she chaired professional advancement sessions to aid young scientists in exploring diverse career paths. Also consistent with this effort, she has been co-chairing the TOXI graduate student and postdoctoral fellow session at the ACS national meetings for the past two years. She is currently the scientific advisor for the Shimadzu Laboratory for Pharmaceutical Research Excellence at the University of Toledo, and leads a laboratory of three doctoral students and two undergraduate students that is developing bioanalytical tools and methods that can be utilized to study genotoxic, epigenetic, and epitranscriptomic modifications to biomolecules that impact human and environmental health. She believes it is important to diversify the participation in the TOXI division, and will be honored to serve as the Member at Large of the Executive Committee.
Deyu Li, Ph.D., is an Assistant Professor and the Paramaz Avedisian Endowed Chair in Medicinal Organic Chemistry in the College of Pharmacy at the University of Rhode Island. Dr. Li received his Ph.D. in organic chemistry from Brown University with Professor Paul G. Williard and did postdoctoral work in Professor John M. Essigmann’s lab at the Massachusetts Institute of Technology. He joined the URI in 2014. His lab develops chemical and genetic tools to study biological outcomes of DNA adducts and solve disease- and environment-related problems. The past several years have been highly productive for his group: they successfully set up a functioning lab and recruited 3 postdoctoral researchers, 10 graduate students, and 27 undergraduate students. His lab was awarded the Outstanding New Environmental Scientist (ONES) Award (RO1) and the Academic Research Enhancement Award (AREA) (R15) from the National Institutes of Health, and secured more than $2.7 million for federal and in-state funding. He was also awarded the Early Career Faculty Research & Scholarship Excellence Award by URI. Because of his achievements in teaching, he was selected by the students as a faculty inductee of The Kappa Psi Pharmaceutical Fraternity (the oldest and largest international pharmacy fraternity) in 2017 and The Rho Chi Society (the academic honor society in pharmacy) in 2019. He is actively participating the activities in the Division of Chemical Toxicology and willing to contribute his efforts to the growth of the division.
The Nominating Committee consists of three members, one elected each year. The member with the longest tenure on the committee shall serve as Chair. Each year the Secretary of the Division contacts the members of the Nominating Committee and stipulates the offices that are to be filled. In making the nominations, the committee should be attentive to issues of diversity and look for broad representation within the membership of the division. The nominations should be submitted to the Executive Committee at their meeting which falls during the national ACS meeting. At the business meeting of the general membership, the Chair should open the floor for additional nominations. Once the nominations are closed, the Secretary should be informed as to the nominees and prepare the ballots accordingly.
Lisa Peterson received her BS in chemistry at Macalester College, St. Paul, MN. She earned her PhD in Pharmaceutical Chemistry at the University of California at San Francisco in the laboratory of Dr. Neal Castagnoli, Jr. After post-doctoral studies at Vanderbilt University in the laboratory of Dr. Fred Guengerich, she joined the Division of Chemical Carcinogenesis at the American Health Foundation in Valhalla, NY. In 1997, Lisa moved to the University of Minnesota where she is now a Professor in the Division of Environmental Health Sciences and co-program leader of the Carcinogenesis and Chemoprevention Program in the Masonic Cancer Center. Her research focuses on mechanisms by which chemicals initiate carcinogenesis. Currently, she is investigating interactions between tobacco smoke chemicals in established rodent tumor models. In addition, she is Principal Investigator of the Minnesota HHEAR Targeted Analysis Lab in the Human Health Exposure Assessment Resource funded by the National Institute of Environmental Health Sciences. Lisa has been an active member of the Division of Chemical Toxicology, American Chemical Society since its inception, serving as chair of the Bylaws Committee (1997-1998), councilor (2002-2004), chair (chair-elect, 2008; chair 2009-2010; immediate past chair, 2011-2012), and member of the nominations committee (2014-2015, chair 2016). She has also served as Treasurer for the International Society for the Study of Xenobiotics. She was an Associate Editor for Chemical Research in Toxicology from 2013-2017.